Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models

Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway

“…Recently, the usage of this drug in clinical applications has been limited because of its potential to increase cardiovascular risk after long-term use (Shah and Mudaliar, 2010). In this study, the cardiovascular-protecting (Cheng et al, 2006;Gao et al, 2010b;Zhao et al, 2003) drug polydatin was determined to have similar effects on glucose and lipid metabolism regulation in diabetic rats with pioglitazone, indicating that polydatin and its derivatives are candidate drugs for glucose and lipid metabolisms regulation.…”

Polydatin: A review of pharmacology and pharmacokinetics

“…It also decreases the size of CM and the levels of aldosterone (ALD), tumor necrosis factor-a (TNF-a), Ang II and endothelin-1 (ET-1), reduces ventricular collagen volume and depresses blood pressure in pressure-overload rats. These results demonstrate that PD has favorable effects on attenuating ventricular remodeling by inhibiting the activation of neurohormone, especially in rennin-angiotensin-ALD system (Gao et al, 2010). PD can also protect rats against myocardial I/R injury by upregulating the levels of superoxide dismutase (SOD), nitric oxide synthase (NOS), constitutive NOS and nitric oxide (NO) and decreasing malondialdehyde (MDA) content (Zhang et al, 2008a).…”

Polydatin modulates Ca2+ handling, excitation–contraction coupling and β-adrenergic signaling in rat ventricular myocytes

“…A number of studies have shown that PD applied in vivo enhanced cardiac function and improved microcirculation in hemorrhagic shock and severe burn injury without interfering with normal hemodynamics [9,14]. Recently, it has been suggested that PD has strong cardioprotective effect against ischemia-reperfusion injury and pressure-overload induced ventricular remodeling [15][16][17]. However, the precise mechanism(s) responsible remains poorly understood.…”