Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway

Hao, Jie; Chen, Cheng; Huang, Kaipeng; Huang, Junying; Li, Jie; Liu, Peiqing; Huang, Heqing

doi:10.1016/j.ejphar.2014.09.047

Cited by 60 publications

(41 citation statements)

References 51 publications

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“…Reportedly, resveratrol can also effectively reduce blood lipid levels in hyperlipidemic mice and improve the functional activity of membrane lipids in the livers of aged subjects such as phospholipid and fatty acid composition, as well as improving ceramide content (Momchilova et al,2014). It has been reported that the glucoside form of resveratrol, polydatin, could also regulate lipid metabolism in diabetic models; which was probably associated with regulation of the Akt pathway (Hao et al, 2014). We are currently endeavoring to detect additional components of JOL that exert anti-RSV effects by regulating lipid metabolism.…”

Section: Discussionmentioning

confidence: 97%

A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry

Xie

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 97%

A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry

Xie

et al. 2015

Journal of Ethnopharmacology

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“…Akt activation activates GK and quickly converts glucose into glucose-6-phosphate. This, in turn, stimulates glycolysis and glycogen storage and has a key role in maintaining glucose homeostasis by controlling glyconeogenesis [5354]. Furthermore, it has been reported that when glucose is supplied to liver cells, the glucose can be converted into glycogen for storage in an insulin-independent situation [30].…”

Section: Discussionmentioning

confidence: 99%

Increased glucose metabolism and alpha-glucosidase inhibition inCordyceps militariswater extract-treated HepG2 cells

et al. 2017

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BACKGROUND/OBJECTIVESRecent living condition improvements, changes in dietary habits, and reductions in physical activity are contributing to an increase in metabolic syndrome symptoms including diabetes and obesity. Through such societal developments, humankind is continuously exposed to metabolic diseases such as diabetes, and the number of the victims is increasing. This study investigated Cordyceps militaris water extract (CMW)-induced glucose uptake in HepG2 cells and the effect of CMW treatment on glucose metabolism.MATERIALS/METHODSColorimetric assay kits were used to determine the glucokinase (GK) and pyruvate dehydrogenase (PDH) activities, glucose uptake, and glycogen content. Either RT-PCR or western blot analysis was performed for quantitation of glucose transporter 2 (GLUT2), hepatocyte nuclear factor 1 alpha (HNF-1α), phosphatidylinositol 3-kinase (PI3k), protein kinase B (Akt), phosphorylated AMP-activated protein kinase (pAMPK), phosphoenolpyruvate carboxykinase, GK, PDH, and glycogen synthase kinase 3 beta (GSK-3β) expression levels. The α-glucosidase inhibitory activities of acarbose and CMW were evaluated by absorbance measurement.RESULTSCMW induced glucose uptake in HepG2 cells by increasing GLUT2 through HNF-1α expression stimulation. Glucose in the cells increased the CMW-induced phosphorylation of AMPK. In turn, glycolysis was stimulated, and glyconeogenesis was inhibited. Furthermore, by studying the mechanism of action of PI3k, Akt, and GSK-3β, and measuring glycogen content, the study confirmed that the glucose was stored in the liver as glycogen. Finally, CMW resulted in a higher level of α-glucosidase inhibitory activity than that from acarbose.CONCLUSIONCMW induced the uptake of glucose into HepG2 cells, as well, it induced metabolism of the absorbed glucose. It is concluded that CMW is a candidate or potential use in diabetes prevention and treatment.

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“…Polydatin may be an effective hepatoprotective agent and a potential candidate for the prevention of fatty liver disease and insulin resistance [71]. The results of Hao et al [72] indicate that polydatin regulates glucose and lipid metabolism in experimental diabetic models, the underlying mechanism is probably associated with regulating the Akt pathway. The effect of polydatin on increased Akt phosphorylation is independent of prompting insulin secretion, but dependent of increasing IRS phosphorylation.…”

Section: Polydatinmentioning

confidence: 99%

BIOLOGICALLY ACTIVE COMPOUNDS OF KNOTWEED (Reynoutria spp.)

Patočka¹,

Navrátilová²,

Ovando³

2017

Mil. Med. Sci. Lett.

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Knotweeds (Reynoutria Houtt.) are plants native to the Far East. Japanese knotweed was introduced from Japan to the unsuspecting West by the horticultural activities of Philippe von Siebold via his nursery at Leiden in the 1840s. By 1854, the plant had arrived at the Royal Botanic Gardens in Edinburgh. The plants were then sold by a large number of commercial nursery gardens around the country. Further vegetative spread followed naturally along watercourses. The knotweed is currently extremely persistant invasive plant. There is also an important source of many bioactive substances which could be used in biomedicine. The article discusses biomedically relevant constituents and its pharmacological and toxicological properties.

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Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway

Cited by 60 publications

References 51 publications

A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry

A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry

Increased glucose metabolism and alpha-glucosidase inhibition inCordyceps militariswater extract-treated HepG2 cells

BIOLOGICALLY ACTIVE COMPOUNDS OF KNOTWEED (Reynoutria spp.)

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