Effects of Polychlorinated Biphenyls 28, 30 and 118 on Bovine Spermatozoa <i>In Vitro</i>

Yurdakok, Begum; Tekin, Koray; Daşkın, Ali; Filazı, Ayhan

doi:10.1111/rda.12447

Cited by 23 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, although this was not true for every case, a number of human studies have pointed to inverse relationships between blood serum or seminal plasma PCBs within the range of current levels for most European populations and standard sperm parameters, particularly with sperm motility, which was found to be more vulnerable to PCB exposure than sperm concentration or morphology (Bush et al 1986. Supporting these findings, non-genomic studies have shown a decrease in motility (Table 1) after exposure to low levels of 2,2 0 ,6,6 0 tetrachlorobiphenyl (PCB54; Roediger et al 1989) and 2,4,4 0 -trichlorobiphenyl (PCB28), 2,4,6-trichlorobiphenyl (PCB30), and 2,3 0 ,4,4 0 ,5-pentachlorobiphenyl (PCB118; Yurdakok et al 2015) in human and bull spermatozoa. Moreover, porcine sperm treated with an organochlorine mixture containing several PCB congeners plus a panoply of other compounds, including pesticides, were also found to reduce both motility and viability in vitro (Campagna et al 2002).…”

Section: Polychlorinated Biphenylssupporting

confidence: 63%

The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

Tavares

Escada-Rebelo

Correia³

et al. 2016

Reproduction

View full text Add to dashboard Cite

Exposure to toxicants present in the environment, especially the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in male reproductive organs over the past decades. Both human and animal populations are continuously exposed to ubiquitous synthetic and natural-occurring EDCs through diet, dermal contact and/or inhalation, therefore potentially compromising male reproductive health. Although the effects of EDC are likely induced via multiple genomic-based pathways, their non-genomic effects may also be relevant. Furthermore, spermatozoa are transcriptionally inactive cells that can come in direct contact with EDCs in reproductive fluids and secretions and are therefore a good model to address non-genomic effects. This review thus focuses on the non-genomic effects of several important EDCs relevant to mammalian exposure. Notably, EDCs were found to interfere with pre-existing pathways inducing a panoply of deleterious effects to sperm function that included altered intracellular Ca 2C oscillations, induction of oxidative stress, mitochondrial dysfunction, increased DNA damage and decreased sperm motility and viability, among others, potentially jeopardizing male fertility. Although many studies have used non-environmentally relevant concentrations of only one compound for mechanistic studies, it is important to remember that mammals are not exposed to one, but rather to a multitude of environmental EDCs, and synergistic effects may occur. Furthermore, some effects have been detected with single compounds at environmentally relevant concentrations.Reproduction (2016) 151 R1-R13

show abstract

Section: Polychlorinated Biphenylssupporting

confidence: 63%

The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

Tavares

Escada-Rebelo

Correia³

et al. 2016

Reproduction

View full text Add to dashboard Cite

show abstract

“…After 24 h incubation, standardized cell viability test, MTT, was done according to our previous studies (Yurdakok et al 2015). Viability of the cells was analyzed by using a microplate reader (SpectraMax i3/ i3x MultiMode Detection Platform, Molecular Devices, Sunnyvale, CA) at 540 nm.…”

Section: Cytotoxicity Assaysmentioning

confidence: 99%

Companion animals get close to the toxic aspects of antropogenic world: cytotoxicity of phthalates and bisphenol A on dog testicular primary cells

et al. 2020

View full text Add to dashboard Cite

Phthalates, which are among the most abundant plasticizers, have detrimental effects on the reproductive system. Similar to human, dogs are prominently exposed to phthalates in daily routines at low concentrations; while toys, training devices and commercial dog foods are considered as the primary sources of exposure. This study aimed to reveal and compare the cytotoxic effects of selected phthalates (Benzyl butyl phthalate (BBP), Diethyl phthalate (DEP), Bis (2-ethylhexyl) phthalate (DEHP), Di-'isobutyl' phthalate (DIBP), Di-'isodecyl' phthalate (-DIDP) Di-'isononyl' phthalate (DINP), Dimethyl phthalate (DMP), Di-n-octyl phthalate (DNOP)), and Bisphenol A (BPA) following 24 h exposure on primary testicular parenchymal cells of dog in vitro at concentrations between 0.001 and 2.5 nM. According to cytotoxicity results, DEHP was found to be the most toxic phthalate with IC 50 at 22.53 lM; while DMP was the least (169.17 nM). IC 50 of BPA was 161.81 nM, less than the average (61.95 nM) of phthalates. In addition, dog primary testicular cells were found more susceptible to the high molecular weight phthalates (DNOP, DEHP, DINP, DIDP) than low molecular weight phthalates (DMP, DEP, DIBP, BBP). Further studies should focus on morphological, physiological and molecular differences to comprehend the mechanisms involved as well as decreasing the risk for impaired spermatogenesis caused by environmental toxicants in companion animal medicine.

show abstract

“…PCBs specifically also produce free radicals in testicular cells that decrease catalase activity which is meant to combat oxidative stress ( 43 ). PCBs are known to inhibit gene expression of steroidogenic enzymes by binding to AhR and androgen receptors, thus resulting in oxidative stress and ultimately apoptosis ( 43 , 44 ) ( Figure 1 ).…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Endocrine disrupting chemicals and impact on male reproductive health

Rehman

Usman

Rehman

et al. 2018

Transl. Androl. Urol.

View full text Add to dashboard Cite

Endocrine disrupting chemicals (EDCs) have been known to adversely affect the endocrine system leading to compromised functions of hormones. The presence of these compounds in everyday products such as canned food, water bottles, plastics, cosmetics, fertilizers, kid’s toys and many others goods is a greater concern for general population. The persistent and long-term use of EDCs has deleterious effects on human reproductive health by interfering with the synthesis and mechanism of action of sex hormones. Any change during the synthesis or action of the sex hormones may result in abnormal reproductive functions which includes developmental anomalies in the reproductive tract and decline in semen quality. The present paper provides an overview of the EDCs and their possible impact on male reproductive health with major focus on semen quality which leads to male infertility.

show abstract

Effects of Polychlorinated Biphenyls 28, 30 and 118 on Bovine Spermatozoa In Vitro

Cited by 23 publications

References 31 publications

The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

Companion animals get close to the toxic aspects of antropogenic world: cytotoxicity of phthalates and bisphenol A on dog testicular primary cells

Endocrine disrupting chemicals and impact on male reproductive health

Contact Info

Product

Resources

About