Endocrine disrupting chemicals and impact on male reproductive health

Rehman, Saba; Usman, Zeenat; Rehman, Sabeen; Aldraihem, Moneera O.; Rehman, Noor; Rehman, Ibraheem; Ahmad, Gulfam

doi:10.21037/tau.2018.05.17

Cited by 97 publications

(66 citation statements)

References 68 publications

(106 reference statements)

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“…The low testosterone levels seen along with low fertility in the F3 DEHP males led us to examine whether their machinery for testosterone production was impaired in those males. Testicular steroidogenesis is an important process for synthesizing testosterone, and any dysfunction on this pathway could impact male fertility 52,[80][81][82] . The paternal lineage F3 males in the 20 µg/kg/day and 200 μg/kg/day DEHP groups had significantly lower Star and Hsd17β1 mRNA expression levels than controls.…”

Section: Discussionmentioning

confidence: 99%

Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations

Barakat¹,

Lin²,

Park³

et al. 2020

Sci Rep

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in males, defective reproductive traits induced by an exposure to an endocrine disruptor are transmitted to future generations via epigenetic modification of the germ cells. Interestingly, the impacted future generations display a wide range of heterogeneity in their reproductive traits. in this study, the role that the Y chromosome plays in creating such heterogeneity is explored by testing the hypothesis that the Y chromosome serves as a carrier of the exposure impact to future generations. this hypothesis implies that a male who has a Y chromosome that is from a male that was exposed to an endocrine disruptor will display a more severe reproductive phenotype than a male whose Y chromosome is from an unexposed male. To test this hypothesis, we used a mouse model in which F1 generation animals were exposed prenatally to an endocrine disruptor, di-2-ethylhexyl phthalate (DEHP), and the severity of impacted reproductive traits was compared between the F3 generation males that were descendants of F1 males (paternal lineage) and those from F1 females (maternal lineage). Pregnant dams (F0 generation) were exposed to the vehicle or 20 or 200 μg/kg/day of DEHP from gestation day 11 until birth. Paternal lineage F3 DEHP males exhibited decreased fertility, testicular steroidogenic capacity, and spermatogenesis that were more severely impaired than those of maternal lineage males. indeed, testicular transcriptome analysis found that a number of Y chromosomal genes had altered expression patterns in the paternal lineage males. This transgenerational difference in the DEHP impact can be attributed specifically to the Y chromosome.

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Section: Discussionmentioning

confidence: 99%

Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations

Barakat¹,

Lin²,

Park³

et al. 2020

Sci Rep

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“…Moreover, the difference between the age groups and the degree of knowledge of respondents about the uses of medicinal plants for the treatment of this reproductive health problem was significant (P < 0.05). Older respondents (40-60) had more knowledge than less aged respondents (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39).…”

Section: Socio-demographic Characteristics Of the Informantsmentioning

confidence: 99%

“…Several reasons can lead to male infertility. It can be a hormonal imbalance [14], genetic anomaly [15,16], systemic disease [17], spermatogenic defect [18], microbial infections [19], immunological disorders [20], endocrine disruptors [21], environmental pollutants and lifestyle [22] (taking steroids for muscles, tobacco, alcohol, obesity, cellphone waves, and tight pants), drug factors etc.…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical Kknowledge of Medicinal Plants Used in the Treatment of Male Infertility in Southern Benin

Agbodjento¹,

Klotoé

Sacramento³

et al. 2020

Preprint

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Background: Infertility is a concern for couples, families and society. In almost half of the cases, it is due to male infertility, which results in the azoospermia and oligospermia. This infertility, in developing countries like Benin, is often care by the use of medicinal medicinal plants. However, very few data exist on plants with spermatogenic benefits at the current stage. Therefore, this work aimed to enlist knowledge about plants used in the treatment of male infertility in southern Benin. Methods : An ethnomedicinal investigation has been conducted by questioning traditional healer and market herbalists using the method of semi-structured interview. A descriptive and quantitative statistical method was used to analyze the socio-demographic data of the informants. ANOVA One-way and Independent Samples T-Test were used to assess the degree of endogenous knowledge of the respondents. Ethnopharmacological data has been analyzed by ethnobotanical indices such as informant consensus factor ( ICF ), frequency of citation ( FC ) for each plant species and contribution of each plant to drug recipes ( Cpr ) to establish indicators on the use values attributed to plants listed.Results: 90 respondents including 34 market herbalists and 54 traditional healers participated in this study. Data collected allowed us, on the basic of 70 recipes provided by the informants, to list 60 plant species belonging to 57 genera and 40 botanical families. Informants had a high degree of consensus (ICF = 0.58) on plants used for treatment of male infertility. The most plants cited were Garcinia kola (10.09%), Cissus populnea (10.09%), Carpolobia lutea (7.40%) among market herbalists and Garcinia kola (10.15%), Cyperus esculentus (06.09%), Citrus aurantifiola (06.09 %) among traditional healers. The recipes composed of 1 to 7 plants prepared mainly in the form of maceration and trituration. Conclusion : Beninese flora has a variety of plants used in the treatment of male infertility. This study provided for the first time a list of medicinal plants used for the treatment of male infertility in southern Benin. Further pharmacological and toxicological studies may be undertaken for the scientific validation of the therapeutic effect of these medicinal plants.

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“…Several studies [18,[27][28][29] linked EDCs to antiandrogenic effects and male sexual disorders, including loss of fertility. Existing circumstantial evidence in human and laboratory studies on animals point to the fact that pathologies such as cryptorchidism, hypospadias, testicular cancer and reduced semen quality may be linked to the exposure to androgen antagonists during fetal development, however further research is needed.…”

Section: Endocrine Disruptors and Human Healthmentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

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Endocrine disrupting chemicals and impact on male reproductive health

Cited by 97 publications

References 68 publications

Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations

Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations

Ethnobotanical Kknowledge of Medicinal Plants Used in the Treatment of Male Infertility in Southern Benin

Endocrine Disruption by Mixtures in Topical Consumer Products

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