Effects of Polarized Training on Cardiometabolic Risk Factors in Young Overweight and Obese Women: A Randomized-Controlled Trial

Zapata-Lamana, Rafael; Henríquez‐Olguín, Carlos; Burgos, Carlos; Meneses‐Valdés, Roberto; Cigarroa, Igor; Soto, Claudio A. Telléz; Fernández-Elías, Valentín E.; Merino, Sonia García; Ramírez‐Campillo, Rodrigo; García-Hermoso, António; Cerda-Kohler, Hugo

doi:10.3389/fphys.2018.01287

Cited by 27 publications

(34 citation statements)

References 65 publications

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“…Exercise intensity is a significant variable explaining the health benefits induced by physical activity [3,4]. Indeed, structured high-intensity interval training (HIIT) has been demonstrated to improve both whole-body and skeletal muscle metabolic health in different populations [[5], [6], [7]]. Despite the proven efficacy of HIIT to promote metabolic health, the underlying mechanisms mediating the molecular adaptations in the HIIT-exercised musculature are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2

et al. 2019

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Objective Reactive oxygen species (ROS) have been proposed as signaling molecules mediating exercise training adaptation, but the ROS source has remained unclear. This study aimed to investigate if increased NADPH oxidase (NOX)2-dependent activity during exercise is required for long-term high-intensity interval training (HIIT) in skeletal muscle using a mouse model lacking functional NOX2 complex due to absent p47phox ( Ncf1 ) subunit expression ( ncf1* mutation). Methods HIIT was investigated after an acute bout of exercise and after a chronic intervention (3x/week for 6 weeks) in wild-type (WT) vs. NOX2 activity-deficient ( ncf1* ) mice. NOX2 activation during HIIT was measured using an electroporated genetically-encoded biosensor. Immunoblotting and single-fiber microscopy was performed to measure classical exercise-training responsive endpoints in skeletal muscle. Results A single bout of HIIT increased NOX2 activity measured as p47-roGFP oxidation immediately after exercise but not 1 h or 4 h after exercise. After a 6-week HIIT regimen, improvements in maximal running capacity and some muscle training-markers responded less to HIIT in the ncf1* mice compared to WT, including superoxide dismutase 2, catalase, hexokinase II, pyruvate dehydrogenase and protein markers of mitochondrial oxidative phosphorylation complexes. Strikingly, HIIT-training increased mitochondrial network area and decreased fragmentation in WT mice only. Conclusion This study suggests that HIIT exercise increases NOX2 activity in skeletal muscle and shows that NOX2 activity is required for specific skeletal muscle adaptations to HIIT relating to antioxidant defense, glucose metabolism, and mitochondria.

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Section: Introductionmentioning

confidence: 99%

Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2

et al. 2019

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“…In this type of training, approximately 75% of total training volume is performed at low intensities and approximately 25% performed at high intensities [19]. This new approach was derived from training schedules of elite endurance athletes, and has been successfully applied in various diseases such as cancer [20] and obesity [21].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a physical activity programme combining individualized aerobic exercise and coaching to improve physical fitness in neuromuscular diseases (I’M FINE): study protocol of a randomized controlled trial

et al. 2020

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Background: In individuals with neuromuscular diseases (NMD), symptoms of muscle weakness, fatigue and pain may limit physical activity. Inactivity leads to reduced physical fitness, which further complicates daily life functioning. Due to inconclusive evidence regarding exercise in NMD, the optimal training approach and strategies to preserve an active lifestyle remain to be determined. The physical activity programme I'M FINE, consisting of individualized aerobic exercise to improve physical fitness and coaching to preserve an active lifestyle, was therefore developed. The primary objective of this study will be to evaluate the efficacy of the I'M FINE programme in terms of improved physical fitness in individuals with slowly progressive NMD, compared to usual care. Methods: A multicentre, assessor-blinded, two armed, randomized controlled trial will be conducted in a sample of 90 individuals with slowly progressive NMD. Participants motivated to improve their reduced physical fitness will be randomized (ratio 1:1) to the I'M FINE intervention or usual care. The I'M FINE intervention consists of a six-month physical activity programme, including individualized home-based aerobic exercise to improve physical fitness (i.e. peak oxygen uptake), and motivational interviewing coaching (e.g. goal setting, self-management) to adopt and preserve an active lifestyle. Measurements will be performed at baseline, post-intervention, and at 12-and 18-months follow-up. The primary outcome is peak oxygen uptake (VO 2 peak) directly post intervention. Main secondary outcomes are physical capacity, muscle strength, self-efficacy, daily activity, quality of life and markers of metabolic syndrome. The primary analysis compares change in VO 2 peak post-intervention between the intervention and usual care group, with analysis of covariance. Discussion: The I'M FINE study will provide evidence regarding the efficacy of a physical activity intervention on the physical fitness and active lifestyle over the short-and long-term in individuals with slowly progressive NMD. These outcomes could potentially improve the (inter)national guidelines for efficacy of aerobic exercise programmes and provide insight in achieving a more active lifestyle in NMD.

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“…Besides, is beneficial to identify these thresholds since it allows establishing the three classical training zones: Zone 1, intensity < VT1; Zone 2, intensities between VT1 and VT2; and Zone 3, intensity > VT2 [12], favoring the control of external and internal training load [13,14]. Despite the usefulness of laboratory evaluations individualizing exercise prescription, access to these measurements at the healthcare level is limited due to the cost of its implementation [15].…”

Section: Introductionmentioning

confidence: 99%

The “Talk Test” is a practical tool to determine aerobic training zones in overweight and obese patients.

Orizola-Cáceres

Cerda-Kohler²,

Burgos-Jara

et al. 2020

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Background: to validate the traditional talk test (TTT) and an alternative talk test (ATT; using a visual analog scale) in overweight/obese (OW-OB) patients and to establish its accuracy in determining the aerobic training zones.Methods: We recruited 19 subjects aged 34.9 ± 6.7 years, diagnosed with overweight/obesity (BMI 31.8 ± 5.7). Every subject underwent incremental cycloergometric tests for maximal oxygen consumption, and TT in a randomized order. At the end of each stage during the TT each subject read out loud a 40 words text and then had to identify the comfort to talk in two modalities: TTT which consisted in answering “Yes”, “I don’t know” or “No” to the question Was talking comfortable?, or ATT through a 1 to 10 numeric perception scale (visual scale analog: VAS). The magnitude of differences was interpreted in comparison to the smallest worthwhile change (SWC) and was used to determine agreement.Results: Agreement between the power output at the VAS 2-3 of ATT and the power output at the ventilatory threshold 1 (very likely equivalent; mean difference -1.3 W, 90 % CL (-8.2; 5.6), % chances for higher/similar/lower values of 0.7/99.1/0.2 %). Also, there was an agreement between the power output at the VAS 6-7 of ATT and the power output at the ventilatory threshold 2 (very likely equivalent; mean difference 11.1 W, 90 % CL (2.8; 19.2), % chances for higher/similar/lower values of 0.0/97.6/2.4 %). Conclusions: ATT is a tool to determine exercise intensity and to establish aerobic training zones for exercise prescription in OW-OB patients.

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Effects of Polarized Training on Cardiometabolic Risk Factors in Young Overweight and Obese Women: A Randomized-Controlled Trial

Cited by 27 publications

References 65 publications

Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2

Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2

Efficacy of a physical activity programme combining individualized aerobic exercise and coaching to improve physical fitness in neuromuscular diseases (I’M FINE): study protocol of a randomized controlled trial

The “Talk Test” is a practical tool to determine aerobic training zones in overweight and obese patients.

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