Effects of platelet-rich plasma on the clinical outcomes and cartilage thickness in patients with knee osteoarthritis

Şen, Ekin İlke; Yeşilyurt, Tuğba; Kesiktaş, Fatma Nur; Dıraçoğlu, Demirhan

doi:10.3233/bmr-181209

Cited by 13 publications

(26 citation statements)

References 36 publications

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“…After screening the title and abstract of the remaining 156 articles, 182 articles were considered as possible relevant articles. These articles were further screened using full‐text analysis, and a total of 31 eligible articles met our inclusion/exclusion criteria and were included for the meta‐analysis 6,17‐46 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of different platelet‐rich plasma injections in the treatment of mild‐moderate knee osteoarthritis: A systematic review and meta‐analysis

Chou

Shih

2021

Int J Clinical Practice

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Aims This study aimed to compare the efficacy of different numbered sets of injections of platelet‐rich plasma (PRP) in the treatment of mild‐moderate knee osteoarthritis (OA). Methods A comprehensive search in three databases of Cochrane Library, Embase, and PubMed was conducted to find relevant articles that investigated the efficacy of PRP injection therapies in the treatment of mild‐moderate knee OA through August 2020. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores were the primary outcomes and visual analogue scale (VAS) was the secondary outcome. The pooled improvements amongst different injection therapies were compared. Results No significant differences in the improvement of WOMAC pain were observed amongst 1‐, 2‐, and 3‐injection therapies at 3‐ (P = .26) and 6‐month (P = .13) follow‐ups. For a 12‐month follow‐up, the difference amongst different therapies reached borderline significance (P = .05) in which 3‐injection therapy had a significantly better improvement than 2‐injection therapy (P = .02) and reached borderline significance compared with 1‐injection (P = .07). However, no significant differences in the improvement of VAS scores were observed amongst three injection therapies for all the follow‐up visits (P > .05). For WOMAC function score, 3‐injection therapy performed significantly better than 1‐injection (P < .00001) or 2‐injection therapy (P < .0001) only at 12‐month follow‐up visit. Conclusions Our results demonstrated that 3‐injection therapy of PRP in the treatment of mild‐moderate knee OA had the best efficacy in pain relief and function improvement compared with 1‐ and 2‐injection therapies.

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Section: Resultsmentioning

confidence: 99%

Efficacy of different platelet‐rich plasma injections in the treatment of mild‐moderate knee osteoarthritis: A systematic review and meta‐analysis

Chou

Shih

2021

Int J Clinical Practice

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“…The search identified 1452 records by title, 14 of which met the inclusion criteria and were included for the analysis [ 10 , 11 , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] ]. Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 summarises the characteristics of the 14 included studies [ 10 , 11 , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] ]. The methodology of the non-randomised studies was classified according to Mathes and Pieper (2017) [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…The methodology of the non-randomised studies was classified according to Mathes and Pieper (2017) [ 30 ]. Our analysis included seven RCTs (n = 688) [ [10] , [11] , [19] , [22] , [26] , [31] , [32] ]; two prospective (n = 119) [ [24] , [25] ]; one retrospective cohort (n = 68) [ 21 ]; and 4 case-series (n = 244) [ 20 , 23 , 27 , 28 ]. The total number of participants included was 1119 (1,169TKAs).…”

Section: Resultsmentioning

confidence: 99%

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The role of Platelet-Rich Plasma (PRP) intraarticular injections in restoring articular cartilage of osteoarthritic knees. A systematic review and meta-analysis

Prodromidis

Charalambous

Moran

et al. 2022

Osteoarthritis and Cartilage Open

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“…Thus, PRP represents an attractive biological strategy aiming at improving the healing potential of tissues with low healing potential, such as cartilage. This led to the wide use of PRP, which showed promising results as a minimally invasive injective treatment of cartilage degeneration and OA [53,55,56], despite some recent findings limiting the initial enthusiasm surrounding this biological approach [57,58]. In fact, after an initial focus on PRP regenerative properties, the current literature suggests a homeostatic articular improvement: PRP might influence the entire joint environment, and synoviocytes are affected by platelet releasate as well as by meniscal cells and MSCs [51,[59][60][61].…”

Section: Discussionmentioning

confidence: 99%

Evidence on ankle injections for osteochondral lesions and osteoarthritis: a systematic review and meta-analysis

Boffa

Previtali

Frattura

et al. 2020

International Orthopaedics (SICOT)

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Purpose To evaluate the evidence supporting safety and effectiveness of intra-articular injective treatments for ankle lesions ranging from osteochondral lesions of the talus (OLT) to osteoarthritis (OA). Methods A systematic review and a meta-analysis were performed on PubMed, Embase, and Cochrane Library in March 2020. Safety was evaluated through the reported side effects and effectiveness through the scores used. The quality of the studies was assessed using the Cochrane Collaboration Risk of Bias 2.0 tool and the Downs and Black checklist. For each outcome, the quality of evidence was graded according to GRADE guidelines. Results Twenty-four studies (21 for OA, 3 for OLT) were included on hyaluronic acid (HA), platelet-rich plasma (PRP), saline, methylprednisolone, botulinum toxin type A (BoNT-A), mesenchymal stem cells (MSCs), and prolotherapy. No severe adverse events were reported. For OLT, a comparison was possible between HA and PRP showing no significant difference. For ankle OA, a significant difference favouring HA versus saline was documented at six months (p < 0.001). The GRADE level of evidence was very low. Conclusion This meta-analysis supports the safety of intra-articular treatment for ankle OA and OLT, while only a very low evidence supports the efficacy of HA in terms of better results versus placebo for the treatment of ankle OA, and other conclusions are hindered by the scarcity of the available literature. This urges further and stronger trials to specifically investigate potential and limitations of these different injective approaches for the treatment of OLT and ankle OA.Keywords Ankle . Intra-articular . Osteoarthritis . Osteochondral lesions of the talus (OLT) . Hyaluronic acid (HA) . Platelet-rich plasma (PRP)

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Effects of platelet-rich plasma on the clinical outcomes and cartilage thickness in patients with knee osteoarthritis

Cited by 13 publications

References 36 publications

Efficacy of different platelet‐rich plasma injections in the treatment of mild‐moderate knee osteoarthritis: A systematic review and meta‐analysis

Efficacy of different platelet‐rich plasma injections in the treatment of mild‐moderate knee osteoarthritis: A systematic review and meta‐analysis

The role of Platelet-Rich Plasma (PRP) intraarticular injections in restoring articular cartilage of osteoarthritic knees. A systematic review and meta-analysis

Evidence on ankle injections for osteochondral lesions and osteoarthritis: a systematic review and meta-analysis

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