Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study

Abstract

Objectives: In this study, we aimed to investigate the effectiveness of intra-articular platelet-rich plasma (PRP) injection in adhesive capsulitis. Patients and methods: Between January 2019 and December 2019, a total of 40 patients (21 males, 19 females; mean age: 57.1±6.5 years; range, 44 to 72 years) with idiopathic adhesive capsulitis were included. The patients were randomly assigned into two equal groups as the PRP and the control group. The PRP group received two doses of PRP via intra-articular route biweekly under ultrasound guidance. No injection was performed to the control group. In both groups, stretching and Codman exercises were applied as a home- based program. The Visual Analog Scale (VAS), range of motion (ROM), and Shoulder Pain and Disability Index (SPADI) scores were evaluated before the treatment and at 2, 6 and 12 weeks after the treatment. Results: There were significant differences in all VAS, SPADI, and ROM scores at all time points after treatment compared to baseline in both groups. At the end of the study, there were significant differences in the active flexion, passive flexion, active abduction, passive abduction, and active external rotation scores at 12 weeks between the groups (p=0.012, p=0.015, p=0.008, p=0.019, and p=0.040, respectively). No significant difference was observed between the groups in terms of VAS and SPADI scores and the other parameters (active and passive extension, active and passive internal rotation, passive external rotation) at 2, 6, and 12 weeks (p>0.05). Conclusion: The addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis.

Is platelet-rich plasma a new solution for shoulder adhesive capsulitis? A systematic scoping review of the literature

“…The detailed characteristics of the included studies are shown in Table 1. We included 6 RCTs [15][16][17][18][19][20] and excluded 8 nonrandomized studies. The study inclusion process is shown in Figure 1.…”

“…The follow-up duration ranged from 6 to 26 weeks, but more than half of the studies (4/6) reported a 12-week follow-up period. [15][16][17]20 Females constituted around 59.2% (339/573) of the total patient population with gender reported. Age was reported using different methods including range, mean, and median.…”

“…Adjunctive therapy in the form of different physical therapy exercises was added to PRP in five studies (see Supplementary Table 2). [15][16][17]19,20 Supplemental analgesia was prescribed in 3 studies. 15,18,20…”

The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

“…PRP can exert an anti-inflammatory effect at the inflammation site by releasing TNF-α, HGF, and lipoxin A4, which are potent anti-inflammatory agents [ 94 , 95 ].…”

Non-Surgical and Rehabilitative Interventions in Patients with Frozen Shoulder: Umbrella Review of Systematic Reviews

“…24 Although it is not possible to define a univocal protocol to date, rehabilitation treatments play a pivotal role in the management of FS, and comprise patient education, stretching exercises, joint mobilization, and manual therapy. 4,[25][26][27] Physical modalities such as low-level laser therapy (LLLT), magnetotherapy, ultrasound (US) therapy, and transcutaneous electrical nerve stimulation (TENS) are also commonly used. [28][29][30] Manipulation under anesthesia (MUA) is another possible procedure which involves scapular stabilization with subsequent flexion, extension, abduction, adduction, internal and external rotation of the shoulder until reaching the final degrees of movement following anesthesia.…”