The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

Thu, Aung Chan

doi:10.12701/jyms.2022.00290

J Yeungnam Med Sci

2022

DOI: 10.12701/jyms.2022.00290

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The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

Aung Chan Thu

Abstract: Musculoskeletal pain is the most common pain reported by patients. Platelet-rich plasma (PRP) is widely used to treat musculoskeletal pain. However, the efficacy of PRP to treat this pain remains controversial. This review highlights the application of PRP in the treatment of musculoskeletal pain. PRP treatment appears to reduce pain and improve function in patients with musculoskeletal pain. However, there are limitations to the currently published studies. These limitations include the PRP preparation method… Show more

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Cited by 8 publications

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“…Moreover, this special issue deals with pain treatment using pulsed radiofrequency (PRF) stimulation and platelet-rich plasma (PRP) injection. Park and Chang [ 8 ] review studies on mechanisms of PRP stimulation for controlling pain, and Thu [ 9 ] reviews studies related to PRP injection in the management of musculoskeletal pain. With the help of these review papers, we hope that clinicians can effectively use PRF stimulation and PRP injections to control pain in patients, thereby enhancing the therapeutic effectiveness of pain control.…”

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confidence: 99%

The blind spot and challenges in pain management

Chang

2022

J Yeungnam Med Sci

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mentioning

confidence: 99%

The blind spot and challenges in pain management

Chang

2022

J Yeungnam Med Sci

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Potential Mechanism of Platelet-rich Plasma Treatment on Testicular Problems Related to Diabetes Mellitus

Hermilasari,

Rizal,

Wirohadidjojo

2023

Prague Med. Rep.

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Diabetes mellitus is a condition of continuously increased blood glucose levels that causes hyperglycemia. This condition can result in disorders of various organs including testicular problems. The use of platelet-rich plasma (PRP) which is contained in several growth factors shows its potential in overcoming testicular problems. This literature review study was conducted to identify the potential of PRP in overcoming various testicular problems due to diabetic conditions.

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Systematic Review of Platelet-Rich Plasma for Low Back Pain

Machado,

Soares,

Vianna de Abreu

et al. 2023

Biomedicines

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Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.

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The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

Cited by 8 publications

References 96 publications

The blind spot and challenges in pain management

The blind spot and challenges in pain management

Potential Mechanism of Platelet-rich Plasma Treatment on Testicular Problems Related to Diabetes Mellitus

Systematic Review of Platelet-Rich Plasma for Low Back Pain

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