Effects of plasma jet, dielectric barrier discharge, photodynamic therapy and sodium hypochlorite on infected curved root canals

Ballout, Husam; Hertel, Moritz; Doehring, Jonas; Kostka, Eckehard; Härtwig, Sven; Paris, Sebastian; Preissner, Saskia

doi:10.1002/jbio.201700186

Cited by 10 publications

(12 citation statements)

References 47 publications

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“…In one study an air-driven jet was used additionally [ 52 ]. Ballout et al used a DBD device and showed no significant reduction after an application time of 60 s [ 35 ]. Concerning plasma devices operating with pure argon, the reduction ranged from no reduction [ 35 ] to 3.2 log 10 units [ 37 ] for treatment up to 60 s. A treatment time over 10 minutes led to a reduction of 1.8 log 10 CFU in minimum [ 36 ] and to a non-detectable number in maximum [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…Ballout et al used a DBD device and showed no significant reduction after an application time of 60 s [ 35 ]. Concerning plasma devices operating with pure argon, the reduction ranged from no reduction [ 35 ] to 3.2 log 10 units [ 37 ] for treatment up to 60 s. A treatment time over 10 minutes led to a reduction of 1.8 log 10 CFU in minimum [ 36 ] and to a non-detectable number in maximum [ 39 ]. For devices operating with argon plus an admixture of oxygen, values ranged from no reduction to 6.6 log 10 CFU for up to 120 s [ 38 , 40 ] Eight studies utilizing helium or helium plus admixtures were included.…”

Section: Resultsmentioning

confidence: 99%

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The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens—A Systematic Review of In-Vitro Studies

et al. 2021

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Interest in the application of cold atmospheric plasma (CAP) in the medical field has been increasing. Indications in dentistry are surface modifications and antimicrobial interventions. The antimicrobial effect of CAP is mainly attributed to the generation of reactive oxygen and reactive nitrogen species. The aim of this article is to systematically review the available evidence from in-vitro studies on the antimicrobial effect of CAP on dental pathogens. A database search was performed (PubMed, Embase, Scopus). Data concerning the device parameters, experimental set-ups and microbial cultivation were extracted. The quality of the studies was evaluated using a newly designed assessment tool. 55 studies were included (quality score 31–92%). The reduction factors varied strongly among the publications although clusters could be identified between groups of set pathogen, working gases, and treatment time intervals. A time-dependent increase of the antimicrobial effect was observed throughout the studies. CAP may be a promising alternative for antimicrobial treatment in a clinically feasible application time. The introduced standardized protocol is able to compare the outcome and quality of in-vitro studies. Further studies, including multi-species biofilm models, are needed to specify the application parameters of CAP before CAP should be tested in randomized clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens—A Systematic Review of In-Vitro Studies

et al. 2021

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“…Plasma technology may also have therapeutic potential [91,92,93]. Therapeutic uses include the treatment of skin diseases [94], blood coagulation [95] as well as dental treatment [96] and applications in dermatology such as chronic wound healing [97]. Recently, the potential application of plasma technology as a novel anticancer therapy has been assessed [98].…”

Section: Future Perspectives In Medicine and Dentistrymentioning

confidence: 99%

Disinfection and Sterilization Using Plasma Technology: Fundamentals and Future Perspectives for Biological Applications

Sakudo

Yagyu

Onodera

2019

IJMS

210

178

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Recent studies have shown that plasma can efficiently inactivate microbial pathogens such as bacteria, fungi, and viruses in addition to degrading toxins. Moreover, this technology is effective at inactivating pathogens on the surface of medical and dental devices, as well as agricultural products. The current practical applications of plasma technology range from sterilizing therapeutic medical devices to improving crop yields, as well as the area of food preservation. This review introduces recent advances and future perspectives in plasma technology, especially in applications related to disinfection and sterilization. We also introduce the latest studies, mainly focusing on the potential applications of plasma technology for the inactivation of microorganisms and the degradation of toxins.

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“…Application of CAP against E . faecalis yielded promising effects, also in other environments (like in root canal treatment) when compared to photodynamic inactivation of microorganisms [58, 59]. Du et al .…”

Section: Discussionmentioning

confidence: 99%

Antibacterial efficacy of cold atmospheric plasma against Enterococcus faecalis planktonic cultures and biofilms in vitro

et al. 2019

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Nosocomial infections have become a serious threat in our times and are getting more difficult to handle due to increasing development of resistances in bacteria. In this light, cold atmospheric plasma (CAP), which is known to effectively inactivate microorganisms, may be a promising alternative for application in the fields of dentistry and dermatology. CAPs are partly ionised gases, which operate at low temperature and are composed of electrons, ions, excited atoms and molecules, reactive oxygen and nitrogen species. In this study, the effect of CAP generated from ambient air was investigated against Enterococcus faecalis, grown on agar plates or as biofilms cultured for up to 72 h. CAP reduced the colony forming units (CFU) on agar plates by > 7 log10 steps. Treatment of 24 h old biofilms of E. faecalis resulted in CFU-reductions by ≥ 3 log10 steps after CAP treatment for 5 min and by ≥ 5 log10 steps after CAP treatment for 10 min. In biofilm experiments, chlorhexidine (CHX) and UVC radiation served as positive controls and were only slightly more effective than CAP. There was no damage of cytoplasmic membranes upon CAP treatment as shown by spectrometric measurements for release of nucleic acids. Thus, membrane damage seems not to be the primary mechanism of action for CAP towards E. faecalis. Overall, CAP showed pronounced antimicrobial efficacy against E. faecalis on agar plates as well as in biofilms similar to positive controls CHX or UVC.

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Effects of plasma jet, dielectric barrier discharge, photodynamic therapy and sodium hypochlorite on infected curved root canals

Cited by 10 publications

References 47 publications

The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens—A Systematic Review of In-Vitro Studies

The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens—A Systematic Review of In-Vitro Studies

Disinfection and Sterilization Using Plasma Technology: Fundamentals and Future Perspectives for Biological Applications

Antibacterial efficacy of cold atmospheric plasma against Enterococcus faecalis planktonic cultures and biofilms in vitro

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