Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model

Koc, Onder; Gündüz, Bülent; Topçuoğlu, Ata; Buğdaycı, Güler; Yılmaz, Fahri; Duran, Bülent

doi:10.1016/j.ejogrb.2010.06.012

Cited by 28 publications

(26 citation statements)

References 34 publications

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“…Melatonin is a broad-spectrum antioxidant and therefore may interfere with the oxidative stress seen in endometriosis (31). The impact of melatonin on the development of endometriosis through oxidative stress balancing was elegantly demonstrated, by a study in which pinealectomised rats with induced endometriosis developed lesions of a volume that was statistically significantly higher than seen in a control group in which (46). In the pinealectomy group, the level of MDA was statistically significantly higher, and SOD and CAT activity was statistically significantly lower.…”

Section: Discussionmentioning

confidence: 97%

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Kocadal¹,

Attar²,

Yıldırım³

et al. 2013

J Turkish German Gynecol Assoc

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Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model. Material and Methods:This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.Results: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly. Conclusion: Abstract ÖzetOriginal Investigation 81

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Section: Discussionmentioning

confidence: 97%

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Kocadal¹,

Attar²,

Yıldırım³

et al. 2013

J Turkish German Gynecol Assoc

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“…The effects of pinealectomy on the progression of endometriosis explants were reversed by melatonin 202 . One study examined the effects of melatonin and level of nutrition on embryo yield during anestrous and breeding season.…”

Section: Melatonin and Ibsmentioning

confidence: 88%

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2013

IJPSR

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ABSTRACT:Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search was undertaken in different electronic databases using various search terms. A total of 225 studies were identified including clinical research studies and basic experiments. Data were extracted individually from the studies and compiled in the end. Results: Melatonin has been used successfully in chronic insomnia and as an anti-oxidant in cancer and other age-related neuro-degenerative disorders, especially Alzheimer's disease and Autistic disorders. Its evidences of use in other conditions remained insufficient and inconclusive. Conclusion: Melatonin therapy may be considered as efficacious and safe in insomnia and as an anti-oxidant; however, other roles needs to be evaluated in further studies.

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“…The impact of melatonin on the development of endometriosis through oxidative stress balancing was elegantly demonstrated by a study in which pinealectomized rats with induced endometriosis developed lesions of a volume statistically significantly higher than seen in a control group in which endometriosis was induced with no previous pinealectomy (37). In the pinealectomy group, the level of MDA was statistically significantly higher, and SOD and CAT activity was statistically significantly lower.…”

Section: Melatoninmentioning

confidence: 95%