Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet

Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen

“…Our data show that the intake of an isoenergetic pair feeding HFD, despite causing no overweight, led to increased visceral adiposity accumulation, adipocyte size and other adverse metabolic and inflammatory alterations, already described by our group (35,36) and consistent with other findings (17, 37-39).…”

Raspberry Supplementation Improves Insulin Signaling and Promotes Brown‐Like Adipocyte Development in White Adipose Tissue of Obese Mice

“…AMPK and Sirt1 are two important energy sensors, which act together with PGC‐1α to regulate energy homeostasis in response to environmental and nutritional stress . The activation of AMPK also stimulates FNDC5/irisin expression via PGC‐1α . Consistently, RB supplementation recovered AMPK phosphorylation and Sirt1 protein content reduced by HFD.…”

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

“…Such discrepancies between the results regarding irisin in our present study and previous findings (6) can be explained not only by the difference in species (rats vs. mice), but also by different types and durations of exercise performed by the rodents in the present work (voluntary exercise by wheel running) and our previous study (forced endurance training using a two-lane treadmill). It is of interest that mWAT can also act as a source of FNDC5, whose expression is upregulated after exercise [72,73,74,75]. It is also interesting that mice with TNBS-induced colitis had a significantly lower FNDC5 expression in mWAT and such an effect was intensified in HFD animals, which supports the involvement of irisin in the cross-talk between the skeletal muscle and adipose tissue.…”