Raspberry Supplementation Improves Insulin Signaling and Promotes Brown‐Like Adipocyte Development in White Adipose Tissue of Obese Mice

Xing, Tong; Kang, Yifei; Xu, Xinglian; Wang, Bo; Du, Min; Zhu, Mei‐Jun

doi:10.1002/mnfr.201701035

Cited by 41 publications

(41 citation statements)

References 45 publications

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“…Research evaluating berries, berry products, or other fruits on the postprandial inflammatory response has been limited and mixed . Anti‐inflammatory effects of red raspberries were suggested by in vivo animal work , but were not supported in the present postprandial acute study paradigm in people with PreDM‐IR.…”

Section: Discussionmentioning

confidence: 62%

“…Anthocyanins and the microbial metabolite of ellagitannins/ellagic acid, urolithins, were shown to play a role in glucose homeostasis . Recent animal data have suggested raspberry intake influences glucose metabolism through AMP‐activated protein kinase (AMPK)/surtuin 1 (SIRT1) and improves insulin sensitivity via the phosphatidylinositol 3 kinase (PI3)/protein kinase B (AKT) kinase signaling pathway . Also, 1 cup of frozen whole red raspberries contains about 6 g of dietary fiber.…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial

Xiao

Zhu

Edirisinghe

et al. 2019

Obesity

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Objective This study investigated the effect of red raspberry intake on meal‐induced postprandial metabolic responses in individuals who have overweight or obesity with prediabetes and insulin resistance (PreDM‐IR), and in metabolically healthy individuals (Reference). Methods Thirty‐two adults (PreDM‐IR, n = 21; Reference, n = 11) were randomized to a controlled, three‐arm, single‐blinded, crossover trial. Participants were provided 0 g of frozen red raspberries (Control), 125 g of frozen red raspberries (RR‐125) (~1 cup), or 250 g of frozen red raspberries (RR‐250) (~2 cups), with a challenge breakfast meal (high carbohydrate/moderate fat) on three separate days. Multiple blood samples were collected up to 8 hours post breakfast with a final blood sample at 24 hours. A snack was provided at 6 hours. Results Breakfast containing RR‐125 and RR‐250 significantly reduced 2‐hour insulin area under the curve, and RR‐250 reduced peak insulin, peak glucose, and 2‐hour glucose AUC compared with Control in the PreDM‐IR group (P < 0.05). Postprandial triglycerides were significantly lower after RR‐125 versus RR‐250 (P = 0.01) but not different from Control (P > 0.05). No significant meal‐related differences were observed for oxidative stress or inflammatory biomarkers. Conclusions Our findings suggest that red raspberries aid in postmeal glycemic control in individuals with PreDM‐IR, reducing glycemic burden with less insulin, which may be related to improved tissue insulin sensitivity.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial

Xiao

Zhu

Edirisinghe

et al. 2019

Obesity

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“…They are widely distributed in fruits, vegetables, and highly present in foods like legumes, cocoa, some cereals as well as in some beverages, such as tea, coffee and wine [ 29 ]. Polyphenols are not essential nutrients for humans but research in nutrition, including epidemiological studies, randomized controlled trials, in vivo and in vitro assays with animal models and cell lines, has shown that long-term and acute intakes can have beneficial effects on weight management and chronic diseases such as CVD, obesity, type 2 diabetes, the onset and development of some cancers and cognitive function [ 13 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Polyphenols and Metabolismmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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“…Dietary intervention has been proven to be a good strategy for improving chronic metabolic diseases, and polyphenols, such as curcumin, anthocyanins, and tea polyphenols, have been found to prevent both obesity and related inflammation and improve MetS in humans and animal models . Thus far, most research on the anti‐obesity properties of tea polyphenols has focused on monophenols (EGCG, ECG, C, etc.…”

Section: Introductionmentioning

confidence: 99%

GC‐(4→8)‐GCG, A Proanthocyanidin Dimer from Camellia ptilophylla, Modulates Obesity and Adipose Tissue Inflammation in High‐Fat Diet Induced Obese Mice

Peng

Jia

et al. 2019

Molecular Nutrition Food Res

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Scope: Excessive fat accumulation in adipose tissue leads to obesity and related chronic inflammation. This study aims to examine the effects of gallocatechin -(4→8)-gallocatechin-3-O-gallate (GC-(4→8)-GCG), a main proanthocyanidin dimer from Camellia ptilophylla (Cocoa tea), on adipocyteand adipose-related inflammation in vivo and in vitro. Methods and results: C57BL/6 mice are fed a high-fat diet (HFD) and GC-(4→8)-GCG (40 or 80 mg kg −1 d −1 ) for 8 weeks. The metabolic profiles, adipose tissue hypertrophy, macrophage infiltration, and inflammatory cytokine production are investigated. Additionally, 3T3-L1 preadipocytes are utilized to investigate the effect of GC-(4→8)-GCG on preadipocyte differentiation and the tumor necrosis factor (TNF)-α-stimulated inflammatory response in vitro. GC-(4→8)-GCG supplementation decreases HFD-induced epididymal white adipose tissue (eWAT) hypertrophy, suppresses proinflammatory cytokine production and macrophage infiltration in eWAT, and improves insulin sensitivity in HFD-induced obese mice. In vitro, GC-(4→8)-GCG shows a strong anti-adipogenic potential in 3T3-L1 preadipocyte by inhibiting the expression of key adipogenic transcription factors and decreasing the production of proinflammatory cytokines by inhibiting the activation of the nuclear factor (NF)-κB, Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT3) and mitogen-activated protein kinase (MAPK) signaling pathways. Conclusion: GC-(4→8)-GCG can modulate obesity and improve obesity-related insulin resistance by inhibiting preadipocyte differentiation and the related proinflammatory responses.

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Raspberry Supplementation Improves Insulin Signaling and Promotes Brown‐Like Adipocyte Development in White Adipose Tissue of Obese Mice

Cited by 41 publications

References 45 publications

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

GC‐(4→8)‐GCG, A Proanthocyanidin Dimer from Camellia ptilophylla, Modulates Obesity and Adipose Tissue Inflammation in High‐Fat Diet Induced Obese Mice

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