“…Since the mechanisms of low-power laser effect in increasing blood flow and local vasodilatation lead to more reparability of soft tissue cells, and considering that low-power laser does not have significant complications, it is used in a wide range of wounds. This method is used for cases that have suffered burns (17). Studies show the high potential of 650 nm laser therapy.…”
Background: Fibroblasts are the most important cells in the healing process of wounds. The motility activity of low-level laser (light) therapy (LLLT) on fibroblast proliferation has been well-established in vitro. Laser treatment for scar removal increases the number of scars. Objectives: This method uses light therapy to remove the outer layer of the skin surface and produce new skin cells to cover the damaged skin cells. Methods: The present research is from an experimental laboratory. First, tissue fibroblast cells were cultured under appropriate conditions. Then, it was exposed to laser radiation with intensities of 650 and 980 nm, and its supernatant solution was used for wound treatment. Interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF) levels were used to check the recovery. Results: The results of the MTT assay showed an increase in the viability of the cell line under laser irradiation. In addition, these evaluations showed an increase in IL-2, TNF-α, and VEGF after 650 and 980 nm laser irradiation compared to the control group after 48 hours. Conclusions: According to the present study, laser therapy has potential therapeutic potential for wound healing. However, more studies are suggested to increase the efficiency and speed up the treatment process.
“…Since the mechanisms of low-power laser effect in increasing blood flow and local vasodilatation lead to more reparability of soft tissue cells, and considering that low-power laser does not have significant complications, it is used in a wide range of wounds. This method is used for cases that have suffered burns (17). Studies show the high potential of 650 nm laser therapy.…”
Background: Fibroblasts are the most important cells in the healing process of wounds. The motility activity of low-level laser (light) therapy (LLLT) on fibroblast proliferation has been well-established in vitro. Laser treatment for scar removal increases the number of scars. Objectives: This method uses light therapy to remove the outer layer of the skin surface and produce new skin cells to cover the damaged skin cells. Methods: The present research is from an experimental laboratory. First, tissue fibroblast cells were cultured under appropriate conditions. Then, it was exposed to laser radiation with intensities of 650 and 980 nm, and its supernatant solution was used for wound treatment. Interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF) levels were used to check the recovery. Results: The results of the MTT assay showed an increase in the viability of the cell line under laser irradiation. In addition, these evaluations showed an increase in IL-2, TNF-α, and VEGF after 650 and 980 nm laser irradiation compared to the control group after 48 hours. Conclusions: According to the present study, laser therapy has potential therapeutic potential for wound healing. However, more studies are suggested to increase the efficiency and speed up the treatment process.
Background and Aim: Chronic wounds are a clinical problem and require intensive standard wound care. However, this is sometimes insufficient to promote healing. Photobiomodulation therapy (PBMT) can be used as an adjunctive therapy to improve wound healing. Various PBMT devices with different properties and parameter settings as well as different animal species can influence a variety of clinical outcomes. This study aims to assess the use of 830 nm PBMT or simultaneous superpulsed and multiple wavelengths (SPMW; 660, 875, and 905 nm) PBMT on chronic wounds in client-owned dogs.
Materials and Methods: This study included 21 client-owned dogs with chronic wounds allocated into three groups: (1) Control group (C) treated with irrigated saline and without PBMT (n=7); (2) L1 group treated with irrigated saline together with the radiation of 830 nm PBMT (n=7); and (3) L2 group treated with irrigated saline together with the radiation of simultaneous SPMW-PBMT (n=7). Wound healing was assessed on the basis of wound size reduction as a percentage of wound area every 2nd day for 15 days using image analysis software (ImageJ software®, National Institutes of Health, Rockville, Maryland, USA).
Results: A significant difference in the percentage of wound area reduction was noted between the C and PBMT groups (L1 and L2; p<0.05). The average percentages of wound area reduction at the end of the study (15 days) were 42.39±20.58, 56.98±24.82, and 61.81±27.18 in the C, L1, and L2 groups, respectively. A steady decrease in wound size was noted in both PBMT and non-PBMT groups, and coefficients were 7.77, 8.95, and 10.01 in the C, L1, and L2 groups, respectively. The percentage of wound area reduction was found to be significantly different between the PBMT and non-BPMT groups on day 7 (p<0.05).
Conclusion: Based on the results of the current study, using either 830 nm PBMT or simultaneous SPMW-PBMT can accelerate the chronic wound healing process in dogs with a significant reduction in wound area. Therefore, it can be used as an adjunctive therapy to improve wound healing in dogs with reduced treatment duration.
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