Effects of phenolic acids on free radical scavenging and heavy metal bioavailability in kandelia obovata under cadmium and zinc stress

Chen, Shan; Lin, Ruiyu; Lu, Haoliang; Wang, Qiang; Yang, Junchang; Liu, Jingchun; Yan, Chongling

doi:10.1016/j.chemosphere.2020.126341

Cited by 50 publications

(28 citation statements)

References 56 publications

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“…Furthermore, SOD, GPx and CAT genes are considered to be regulated with such kind antioxidant response elements (Saha et al 2020). So we suggest that ZCoNPs in combination with ZCaNPs arrive at the transcriptional agents and stimulate the gene expression during cell oxidation resulting in an augment in the synthesis of the antioxidant enzyme such as blood SOD, GSH, GPx, CAT (Kanagaraj et al 2015).It is well documented thatP-coumaric and caffeicacids have the ability tostimulate the activity of phase II detoxicationenzymes and oxidative stress inhibition (Chen et al 2020).The location of the hydroxyl groups in the ZCoNPs and ZCaNPs might share in the stimulation of γ-glutamyl cysteine synthase, the rate-limiting enzyme implicated in the glutathione production (Lee et al 2016).…”

Section: Discussionmentioning

confidence: 93%

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

et al. 2021

Preprint

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Zinc Coumarate and zinc caffeiatenano-particles (ZCoNPs, ZCaNPs) have been shown to affectthe different biological processes. This work was undertaken to evaluate the mitigating action of ZCoNPs in combination with ZCaNPsagainst liver damage induced by gamma rays (γ-rays). Rats were exposed to 7Gy of γ-rays, and theninjected intraperitoneally (i.p.) with ZCoNPs [2U / rat / day (5 mg/kg)], and ZCaNPs [2U / rat / day (15 mg/kg)] for 7 consecutive days.The results showed that irradiated rats treated with ZCoNPs (5 mg/kg/body weight) in combination with ZCaNPs (15 mg/kg/body weight) for 7 days revealed a significant increase in the body weight, antioxidants levels, T Helper (CD4) Cell and T Cytotoxic (CD8), associated with amarked decrease in the level of lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. Moreover, positive alterations in the morphological state, hematological parameters, and thecell cycle phases were noticed. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment.Thus, ZCoNPs and ZCaNPscould be usedas a natural mitigating agent to reduce the hazards of ionizing radiation.

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Section: Discussionmentioning

confidence: 93%

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

et al. 2021

Preprint

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“…Total phenolic and flavonoid contents in the hydromethanolic extract of W. saharae were found to be 119.8 ± 8.3 mg GAE/g of extract and 24.25 ± 0.070 mg QE/g extract, respectively. The most important properties of these compounds are their capacity to act as potent antioxidant [ 41 ], anti-inflammatory [ 42 ], anti-atherogenic [ 43 ], and anti-carcinogenic agents [ 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Antioxidant, Anti-Inflammatory, and Enzyme Inhibitory Activities of an Endemic Species from Southern Algeria: Warionia saharae

et al. 2021

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Warionia saharae Benth. & Coss. (Asteraceae) is an endemic species of North Africa naturally grown in the southwest of the Algerian Sahara. In the present study, this species’ hydromethanolic leaf extract was investigated for its phenolic profile characterized by ultra-high-performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC-DAD-ESI/MS). Additionally, the chemical composition of W. saharae was analyzed by gas chromatography–mass spectrometry, and its antioxidant potential was assessed through five in vitro tests: DPPH● scavenging activity, ABTS●+ scavenging assay, galvinoxyl scavenging activity, ferric reducing power (FRP), and cupric reducing antioxidant capacity. The UHPLC-DAD-ESI/MS analysis allowed the detection and quantification of 22 compounds, with taxifolin as the dominant compound. The GC–MS analysis allowed the identification of 37 compounds, and the antioxidant activity data indicate that W. saharae extract has a very high capacity to capture radicals due to its richness in compounds with antioxidant capacity. The extract also showed potent α-glucosidase inhibition as well as a good anti-inflammatory activity. However, weak anti-α-amylase and anticholinesterase activities were recorded. Moreover, an in silico docking study was performed to highlight possible interactions between three significant compounds identified in W. saharae extract and α-glucosidase enzyme.

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“…Chlorogenic acid has many biological functions, such as scavenging free radicals; stimulating the central nervous system; producing hypolipidemic, antihypertensive, antiseptic and anti-inflammatory effects and tumor inhibition. 46,47 Chlorogenic acid is an important dietary antioxidant component. The antioxidant activity of chlorogenic acid mainly derives from its ability to scavenge free radicals but is also related to the lipid peroxidation level in the body.…”

Section: Classification Of Polyphenolic Compounds and An Overview Of Their Biological Functionsmentioning

confidence: 99%

“…Studies have shown that chlorogenic acid can supply hydrogen atoms to free radicals (DPPH · , ABTS + · , · O 2 - , · OH, and ONOO – · ) to suppress the occurrence of oxidative damage and is oxidized to a phenoxy radical and subsequently reaches a steady state by resonance. 47 -49 Chlorogenic acid can also chelate with metal ions to reduce the oxidative damage caused by these ions. 47,50 -53 Yang et al showed that chlorogenic acid easily chelates with ferrous ions, blocking · OH production by the Fenton reactionand protecting cells from oxidative damage.…”

Section: Classification Of Polyphenolic Compounds and An Overview Of Their Biological Functionsmentioning

confidence: 99%

“…47 -49 Chlorogenic acid can also chelate with metal ions to reduce the oxidative damage caused by these ions. 47,50 -53 Yang et al showed that chlorogenic acid easily chelates with ferrous ions, blocking · OH production by the Fenton reactionand protecting cells from oxidative damage. 54 Shibata et al found that chlorogenic acid can prevent NH 2 Cl-induced plasmid DNA fragmentation in neutrophils, suggesting that chlorogenic acid can inhibit DNA damage caused by redox reaction byproducts.…”

Section: Classification Of Polyphenolic Compounds and An Overview Of Their Biological Functionsmentioning

confidence: 99%

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Current State of Knowledge on the Antioxidant Effects and Mechanisms of Action of Polyphenolic Compounds

Long

Gong

et al. 2021

Natural Product Communications

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Quality-of-life improvements have resulted in increasing attention being paid to research on antiaging and antioxidation. Polyphenols are natural antioxidants with excellent biological activities, such as antioxidation and scavenging of free radicals and antiviral activity. Abundant availability and low toxicity of polyphenols have attracted the attention of researchers. In this paper, the antioxidant activities of flavonoids, phenolic acids, stilbenes and lignan polyphenols are analyzed, the corresponding antioxidant mechanisms are investigated, and the antioxidant effects of polyphenols are systematically reviewed. Thus, an effective reference based on the recent literature is compiled for the study of the antioxidant mechanisms of polyphenols that provides a significant theoretical basis for the development of products that are components of polyphenols.

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Effects of phenolic acids on free radical scavenging and heavy metal bioavailability in kandelia obovata under cadmium and zinc stress

Cited by 50 publications

References 56 publications

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

Chemical Composition and Antioxidant, Anti-Inflammatory, and Enzyme Inhibitory Activities of an Endemic Species from Southern Algeria: Warionia saharae

Current State of Knowledge on the Antioxidant Effects and Mechanisms of Action of Polyphenolic Compounds

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