Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort

Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries: A Systematic Review and Meta-Analysis

“…The findings of this systematic review reveal a crucial positive association between pesticide exposure and DNA damage in Arab countries, which is not only supported by the individual study findings, but also by the pooled result of the meta-analysis on the weighted sum of breaks. These findings are consistent with the previous literature from other regions of the world [ 34 , 35 , 36 ], emphasizing the potential health risks associated with pesticide exposure in agricultural settings. However, it is important to note that the scarcity of research in the broader Arab region indicates a significant gap in our understanding of this issue locally.…”

Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women

“…However, to our knowledge, this is the first time that the suitability of the approach is shown for extraction and analysis of human biological liquid material such as lyophilized urine. Our additional studies indicate outstanding performance of the method also for other biomarkers and analytes such nucleotides and nucleosides and their methylated and hydroxylated variants ( Janoš et al, 2023 ), benzotriazoles, benzothiazoles, and various other UV stabilizers, tyrosine derivatives etc. The present study thus suggests general applicability of the new method for many other analytes or biomarkers in urine or blood samples after lyophilization.…”

Endocrine disrupting chemicals and male fertility: from physiological to molecular effects

“…Subsequently, all other spermatogenic cells are undifferentiated, altered and then depleted, which may result in the decrease of testis weight and sperm count ( 109 ). The mechanisms underlying these disruptions are complex and can involve several pathways including hormone disruption ( 110 ), Sertoli cells dysfunction, Leydig cells dysfunction ( 111 ), epigenetic changes ( 112 ), oxidative stress ( 113 , 114 ), and disruption of blood-testis barrier ( 115 , 116 ).…”