Effects of Peripheral μ, δ, and κ-Opioid Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats

Alexeeva, Elena; Назарова, Г. А.; Sudakov, S. K.

doi:10.1007/s10517-012-1809-2

Cited by 20 publications

(22 citation statements)

References 8 publications

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“…Moreover, social status also contribute to the behavioral responses observed following KOR activation in adults (Kudryavtseva et al, 2006). Although few studies have examined the behavioral effects of KOR activation in adolescents, all of them have shown that KOR agonists are anxiolytic in stress- and drug-naïve younger animals (Alexeeva et al, 2012; Braida et al, 2009; Privette and Terrian, 1995), particularly when infused in specific brain structures, such as the infralimbic cortex (Wall and Messier, 2000). Furthermore, adolescents display reduced aversion to systemic injections of KOR agonists (Anderson et al, 2014; Tejeda et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats

Przybysz

Werner

2017

Neuropharmacology

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Anxiety disorders are one of the most common and debilitating mental illnesses worldwide. Growing evidence indicates an age-dependent rise in the incidence of anxiety disorders from adolescence through adulthood, suggestive of underlying neurodevelopmental mechanisms. Kappa opioid receptors (KORs) are known to contribute to the development and expression of anxiety; however, the functional role of KORs in the basolateral amygdala (BLA), a brain structure critical in mediating anxiety, particularly across ontogeny, are unknown. Using whole-cell patch-clamp electrophysiology in acute brain slices from adolescent (postnatal day (P) 30–45) and adult (P60+) male Sprague-Dawley rats, we found that KOR activation increased the frequency of GABAA-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in the adolescent BLA, without an effect in the adult BLA or on sIPSC amplitude at either age. The KOR effect was blocked by the KOR antagonist, nor-BNI, which alone did not alter GABA transmission at either age, and the effect of the KOR agonist was TTX-sensitive. Additionally, KOR activation did not alter glutamatergic transmission in the BLA at either age. In contrast, U69593 inhibited sIPSC frequency in the central amygdala (CeA) at both ages, without altering sIPSC amplitude. Western blot analysis of KOR expression indicated that KOR levels were not different between the two ages in either the BLA or CeA. This is the first study to provide compelling evidence for a novel and unique neuromodulatory switch in one of the primary brain regions involved in initiating and mediating anxiety that may contribute to the ontogenic rise in anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats

Przybysz

Werner

2017

Neuropharmacology

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“…The number of lever pressings for obtaining one food granule was daily increased in a certain sequence (1,2,4,8,16, and 32) over 6 experimental days, respectively. Beyond the experimental situation (1-h testing), the animals had a restricted access to food (8 g standard combined feed per day).…”

Section: Methodsmentioning

confidence: 99%

“…Vagal afferentation transmits information on activation of μ-opioid receptors (OR) into CNS, which is followed by suppression of the central endogenous opioid system. These changes are accompanied by inhibition of feeding behavior [1]. However, little is known about the effect of peripheral agonists of various subtypes of OR on LFM.…”

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confidence: 99%

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

2015

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We studied the effect of intragastric administration of peptide agonists of μ-opioid receptors (DAMGO) and δ-opioid receptors (DADLE) on food consumption and food motivation during operant feeding behavior of different intensity and effectiveness. To obtain one food granule, trained rats should press a lever 1 time (day 1), 2 times (day 2), 4 times (day 3), 8 times (day 4), 16 times (day 5), or 32 times (day 6). Activation of δ-opioid receptors in the stomach was followed by suppression of feeding behavior at low energy expenditure. The level of food motivation under these conditions practically did not differ from the control. Activation of μ-opioid receptors in the stomach suppressed energy-consuming feeding behavior, which was accompanied by an increase in the level of food motivation. It can be hypothesized that protein metabolites exhibiting μ-opioid activity probably provide afferent signals into CNS via the vagus nerve to terminate energy expenditure under adverse conditions (although food motivation is not satisfied). Food motivation under these conditions probably contributes to the behavior aimed towards the search for more available food.

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“…It was hypothesized that consumption of large volumes of ethanol-containing solutions induces pathophysiological changes in peptide systems regulating blood volume [7] and appetite [5]. The lastnamed system also includes opioid peptides [8,11].Our previous studies showed that changes in activity of some receptors in the stomach can modulate the pain sensitivity [4], locomotor activity [2], and level of anxiety in rats [1,3]. It cannot be excluded that gastric distention of various degrees affects the affinity and bioavailability of receptors.…”

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confidence: 99%

“…Our previous studies showed that changes in activity of some receptors in the stomach can modulate the pain sensitivity [4], locomotor activity [2], and level of anxiety in rats [1,3]. It cannot be excluded that gastric distention of various degrees affects the affinity and bioavailability of receptors.…”

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confidence: 99%

Anxiolytic, Psychostimulant, and Analgesic Effects of Various Volumes of Ethanol Solution in Different Concentrations, but in the Same Dose

et al. 2016

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We studied the effect of ethanol (dose 2 g/kg) in various concentrations (5, 13, and 40%) and different volumes (40, 15.5, and 5 ml/kg) on the level of anxiety, locomotor activity, and pain sensitivity in rats. Administration of 40 ml/kg water to animals was followed by a significant increase in the time spent in the open arms of the elevated plus maze. Administration of water in a volume of 5 or 15.5 ml/kg had little effect on the level of anxiety. The greater was the volume of intragastrically administered ethanol, the stronger was the anxiolytic effect. The psychostimulant and analgesic effects of ethanol were more pronounced after administration of medium volumes and intermediate concentrations of ethanol-containing solutions. Since administration of these solutions cannot produce maximum blood concentration of ethanol, we believe that the observed effects are mainly related to the direct effect of ethanol on the stomach tissue.

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Effects of Peripheral μ, δ, and κ-Opioid Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats

Cited by 20 publications

References 8 publications

Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats

Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

Anxiolytic, Psychostimulant, and Analgesic Effects of Various Volumes of Ethanol Solution in Different Concentrations, but in the Same Dose

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