Anxiolytic, Psychostimulant, and Analgesic Effects of Various Volumes of Ethanol Solution in Different Concentrations, but in the Same Dose

Abstract

We studied the effect of ethanol (dose 2 g/kg) in various concentrations (5, 13, and 40%) and different volumes (40, 15.5, and 5 ml/kg) on the level of anxiety, locomotor activity, and pain sensitivity in rats. Administration of 40 ml/kg water to animals was followed by a significant increase in the time spent in the open arms of the elevated plus maze. Administration of water in a volume of 5 or 15.5 ml/kg had little effect on the level of anxiety. The greater was the volume of intragastrically administered ethanol, the stronger was the anxiolytic effect. The psychostimulant and analgesic effects of ethanol were more pronounced after administration of medium volumes and intermediate concentrations of ethanol-containing solutions. Since administration of these solutions cannot produce maximum blood concentration of ethanol, we believe that the observed effects are mainly related to the direct effect of ethanol on the stomach tissue.

Dose and Radioadaptive Response Analysis of Micronucleus Induction in Mouse Bone Marrow

“…In relation to human radiation risk estimates, the most valuable experimental studies are those studying in vivo biological effects. Radio-adaptation or effects of low-dose irradiation have been demonstrated in vivo in mice for a variety of biological endpoints related to cellular toxicity and genotoxicity, oxidative stress, inflammation and immunity [ 18 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Increased lifespan, enhanced survival following high-dose radiation, decreased spontaneous and radiation-induced carcinogenic potential and suppression of tumour metastases have been identified as health risks in mice that are modified following chronic or acute low-dose irradiation [ 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”