“…In addition, serum concentrations of inflammatory mediators and/or C-reactive protein (CRP) were evaluated in 10 studies and compared to glycemic te sts. 11,15,16,18,21,22,25,26,28,30 Regarding prospective clinical trials, CPT improved periodontal conditions in PI, GBI, BP, CIL and/or PD, but in a minority there were no improvements in CIL and/or PD. 14,19,22,24,27 With regard to the influence of CPT on glycemic control in patients with diabetes and periodontitis, it was found that 06 studies, 11,15,22,23,30,32 out of these 23 clinical trials, did not detect any benefit from reductions in periodontal inflammatory parameters, obtained after CPT, on glycemic tests, especially HbA1C.…”