Effects of pericardiectomy on training- and myocardial infarction-induced left ventricular hypertrophy, chamber dimensions and gene expression

Wolff, Ariane; Rasmussen, Tyler P.; Wichern, Colter; Peterson, Magnus; Stayton, Mark M.; Thomas, D. P.

doi:10.1055/s-0042-115567

Cited by 4 publications

(7 citation statements)

References 33 publications

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“…To the best of our knowledge, no previous study has examined the apoptosis signaling pathway in response to METH and HIIT. However, the results of the present study agree with those of Delfan et al [ 33 ], Lu et al [ 24 ], and Wolff et al [ 26 ]. Delfan et al [ 33 ] and Lu et al [ 24 ] suggested that HIIT reduces caspase-3 gene expression in rat models of diabetes and myocardial infarction.…”

Section: Discussionsupporting

confidence: 93%

“…Delfan et al [ 33 ] and Lu et al [ 24 ] suggested that HIIT reduces caspase-3 gene expression in rat models of diabetes and myocardial infarction. Additionally, Wolff et al [ 26 ] showed that treadmill training (15° inclination and 22 m/min) increases the melusin mRNA concentration in myocardial infarction and pericardiectomy mice.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Banaei et al [ 25 ] showed that rats with myocardial ischemia–reperfusion injury showed no reduction in caspase-3 protein in response to HIIT. Moreover, Wolff et al [ 26 ] observed that 10 weeks of training on a treadmill increased the melusin mRNA concentration in rats with myocardial infarction and pericardiectomy.…”

Section: Introductionmentioning

confidence: 99%

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Effect of High-Intensity Interval Training on Cardiac Apoptosis Markers in Methamphetamine-Dependent Rats

Shahrabadi

Haghighi

Askari

et al. 2022

CIMB

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Chronic methamphetamine use increases apoptosis, leading to heart failure and sudden cardiac death. Previous studies have shown the importance of high-intensity interval training (HIIT) in reducing indices of cardiac tissue apoptosis in different patients, but in the field of sports science, the molecular mechanisms of apoptosis in methamphetamine-dependent rats are still unclear. The present article aimed to investigate the changes in cardiac apoptosis markers in methamphetamine-dependent rats in response to HIIT. Left ventricular tissue was used to evaluate caspase-3, melusin, FAK, and IQGAP1 gene expression. Rats were divided into four groups: sham, methamphetamine (METH), METH-control, and METH-HIIT. METH was injected for 21 days and then the METH-HIIT group performed HIIT for 8 weeks at 5 sessions per week. The METH groups showed increased caspase-3 gene expression and decreased melusin, FAK, and IQGAP1 when compared to the sham group. METH-HIIT showed decreased caspase-3 and increased melusin and FAK gene expression compared with the METH and METH-control groups. The IQGAP1 gene was higher in METH-HIIT when compared with METH, while no difference was observed between METH-HIIT and METH-control. Twenty-one days of METH exposure increased apoptosis markers in rat cardiac tissue; however, HIIT might have a protective effect, as shown by the apoptosis markers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Effect of High-Intensity Interval Training on Cardiac Apoptosis Markers in Methamphetamine-Dependent Rats

Shahrabadi

Haghighi

Askari

et al. 2022

CIMB

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“…Indicators of endurance training adaption suggest that our trained mice underwent sufficient training, because we report higher maximal running velocities as well as higher heart weight/ body weight for both sexes. Further, previous work from our group reports elevated citrate synthase activity in the quadriceps femoris of mice who underwent a similar training protocol [12]. Thus perhaps differences (physiological, psychological) exist between forced and voluntary exercise that explain the differences between males and females in our data.…”

Section: Discussionsupporting

confidence: 55%

“…An exhaustive exercise test was performed using a modified graded protocol as previously published [12,13]. Briefly, the test began at 15 m/min for the SED group and 20 m/min for TR group.…”

Section: Exhaustive Exercise Testmentioning

confidence: 99%

Sex Differences in Cardiac AMP-Activated Protein Kinase Following Exhaustive Exercise

Brown

Waggy

Nair

et al. 2020

Sports Med Int Open

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Ischemic heart disease presents with significant differences between sexes. Endurance exercise protects the heart against ischemic disease and also distinctly impacts male and female patients through unidentified mechanisms, though some evidence implicates 5′-AMP-activated protein kinase (AMPK). The purpose of this investigation was to assess the impact of training and sex on cardiac AMPK activation following exhaustive exercise. AMPK activation was measured in trained and sedentary mice of both sexes. Trained mice ran on a treadmill at progressively increasing speeds and duration for 12 weeks. Trained and sedentary mice of both sexes were euthanized immediately following exhaustive exercise and compared to sedentary controls. Endurance training elicited adaptations indicative of aerobic adaptation including higher max running velocities and cardiac hypertrophy with no differences between males and females. AMPK activity was higher in male compared to females, and trained exhibited higher AMPK activity compared to sedentary mice. In response to training, male mice activated AMPK more robustly than female mice. Chronic exercise training increases the ability to activate cardiac AMPK in response to exhaustive exercise in a sex-specific manner. Understanding the interaction between exercise and sex is vital for use of exercise as medicine for heart disease in both men and women.

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Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury

Afousi

Gaeini

Rakhshan

et al. 2018

J. Cell Commun. Signal.

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Regulated necrosis (necroptosis) plays a pivotal role in the extent of cardiomyocyte loss and the development of post-ischemic adverse remodelling and cardiac dysfunction following myocardial I/R injury. Although HIIT has been reported to give rise to cardioprotection against MI, but the detailed knowledge of its molecular targets for treatment of MI is still not available. The LAD of Male Wistar rats was occluded to induce MI for 30 min and reperfusion for eight weeks. We investigated the effect of long-term HIIT for eight weeks on lipid peroxidation, SOD activity and GSH content using ELISA assay. Cardiac function, fibrosis, and infarct size were assessed by echocardiography, Masson's trichrome and Evans Blue/TTC dual staining respectively. The expressions of gene markers of myocardial hypertrophy, fibrosis and key mediators of necroptosis were measured using RT-PCR and western blotting assay respectively. The results indicated that HIIT reduced lipid peroxidation, infarct size and improved endogenous antioxidant system and heart function. Significant decreases in mRNA levels of procollagen α1(I), α1(III), and fibronectin1were observed following HIIT. Moreover, that HIIT significantly decreased the expression of key mediators of necroptosis induced by MI (P < 0.05). There were no significant differences in β-MHC mRNA level in different groups. The findings of study suggest that HIIT might exert cardioprotective effects against post-ischemic adverse remodeling through targeting necroptosis process. Likewise, cardioprotective effects of HIIT in coping with myocardial I/R injury may be associated with RIP1-RIP3-MLKL axis. These findings establish a critical foundation for higher efficiency of exercise-based cardiac rehabilitation post-MI and future research.

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Effects of pericardiectomy on training- and myocardial infarction-induced left ventricular hypertrophy, chamber dimensions and gene expression

Cited by 4 publications

References 33 publications

Effect of High-Intensity Interval Training on Cardiac Apoptosis Markers in Methamphetamine-Dependent Rats

Effect of High-Intensity Interval Training on Cardiac Apoptosis Markers in Methamphetamine-Dependent Rats

Sex Differences in Cardiac AMP-Activated Protein Kinase Following Exhaustive Exercise

Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury

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