Effects of perfluorooctanoic acid (PFOA) on the thyroid status, vitellogenin, and oxidant–antioxidant balance in the Murray River rainbowfish

The effects of exposure to environmentally relevant PFAS concentrations for aquatic organisms at different consumer trophic levels: Systematic review and meta-analyses

“…The data behind these results are rather robust and give a reasonable statistical power for concluding that the effects of PFAS exposure on Gonado-Somatic Index (GSI) and Hepato-Somatic Index (HIS) for secondary consumers is nonsignificant. The PFAS effect on GSI result is based on 21 effect sizes and 11 publications (Miranda et al, 2020;Bao et al, 2019;Chen et al, 2019;Du et al, 2009;Giari et al, 2015;Giari et al, 2016;Liu et al, 2010;Shi et al, 2018;Tang et al, 2020;Zhang et al, 2016), while data of HSI is based on 15 effect sizes and 8 publications (Oakes et al, 2010;Miranda et al, 2020;Bao et al, 2019;Giari et al, 2015;Giari et al, 2016;Lou et al, 2013;Shi et al, 1987;Zhang et al, 2012). However, when PFOS was analyzed separately a significant HSI effect was found, in exposed individuals indicating an enlarged liver.…”

Influence of the Linear Alkylbenzene Sulfonate (LAS) on hematological and biochemical parameters of Nile Tilapia, Oreochromis niloticus

“…Reduction in GSH concentration in this study might be explained by the increased concentrations of detergents that induce severe oxidative stress may be either due to suppression of GSH levels in response to xenobiotics due to loss of adaptive mechanisms or oxidation of GSH to GSSG to eliminate the produced ROS ( Bradai et al, 2014 ). Decrease in the activity of CAT and SOD and concentration of GSH in the present study was harmonized with the investigations proceeded on Ruditapes phillipinarum treated with non-ionic surfactant NPEO ( Alvarez-Munoz et al, 2006 ), Solea senegalensis ( Alvarez-Munoz et al, 2007 ), Anabas testudineus ( Nair et al, 2017 ), Danio rerio ( Sobrino-Figueroa, 2013 ) exposed to commercial detergents and LAS, Prochilodus lineatus ( Modesto and Martinez, 2010 ) exposed to Roundup Transorb (RDT) which is a glyphosate-based herbicide containing a mixture of surfactants, Oreochromis niloticus ( Atli and Canli, 2010 ) exposed to sublethal concentrations of metals and Melanotaenia fluviatilis ( Miranda et al, 2020 ) subjected to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), which are a group of persistent anthropogenic organic surfactants. However, the present investigation conflicted with the findings of Shukla and Trivedi (2018) which showed elevation in both SOD and CAT activities in Channa punctatus and the stimulating effect of LAS whether was alone or additively with detergents on oxidative stress.…”

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

“…PFOS exposure increased the net energetic cost of transport of Qingbo Spinibarbus sinensis and had an important influence on routine metabolic rate, spontaneous swimming behavior, social interactions, and critical swimming speed; many of these effects also changed concerning temperature (Xia et al, 2015). PFOA altered T3/T4 ratios and the presence of vitellogenin in the plasma of male M. fluviatilis (Miranda et al, 2020).…”

“…Acute EC50 values for PFOS and PFOA were 0.11 mg/L and 111.9 mg/L for Psetta maxima; 6.9 mg/L and 15.5 mg/L for Siriella armata (Mhadhbi et al, 2012). The peroxides generated from PFOA exposure can cause irreversible damage to vital organs of Murray River rainbowfish (Melanotaenia fluviatilis), such as gills and liver tissues (Miranda et al, 2020). Combined exposure to PFOS, PFOA, and Cu impairs antioxidant defenses and enhances lipid peroxidation in the liver of Carassius auratus (Feng et al, 2015).…”