The effects of exposure to environmentally relevant PFAS concentrations for aquatic organisms at different consumer trophic levels: Systematic review and meta-analyses

Banyoi, Silvia-Maria; Porseryd, Tove; Larsson, Josefine; Grahn, Mats; Dinnétz, Patrik

doi:10.1016/j.envpol.2022.120422

Cited by 17 publications

(4 citation statements)

References 88 publications

(118 reference statements)

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“…PFAS are associated with adverse human health effects, and fish consumption has been associated with higher PFAS concentrations in humans . Some states have issued advisories to limit fish consumption, − and piscivorous wildlife are also subject to adverse effects from PFAS. , Specific advisories exist for some states, including New York State in certain water bodies, such as Beaverdam Lake, Washington Lake, and Lockwood Basin, where advisories are “don’t eat” for all fish…”

Section: Introductionsupporting

confidence: 67%

Two for the Price of One: Deriving Per- and Polyfluoroalkyl Substances (PFAS) Fillet and Whole-Body Conversion Equations in Fish

Levanduski,

Richter,

Becker

et al. 2024

Environ. Sci. Technol. Lett.

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Section: Introductionsupporting

confidence: 67%

Two for the Price of One: Deriving Per- and Polyfluoroalkyl Substances (PFAS) Fillet and Whole-Body Conversion Equations in Fish

Levanduski,

Richter,

Becker

et al. 2024

Environ. Sci. Technol. Lett.

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“…Police dogs exposed to firefighting foams and laboratory beagles exposed to dietary PFAS showed dose-dependent alterations in amylase, cholesterol, and several indicators of blood chemistry at ΣPFAS levels averaging 3.6 ng/ml (maximum 16.6 ng/ml) (You et al, 2022). Aquatic secondary consumers, mainly fish, were adversely affected by serum PFAS as low as 13.5 ng/mL (Banyoi et al, 2022). Immunotoxicity resulted from very low daily doses of 6:2 FTS in white-footed mice (Bohannon et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

“…In wildlife, the evidence for negative health effects of PFAS is largely preliminary, but a growing list of studies have reported specific detrimental effects and declines in overall condition (D’Hollander et al, 2014; Costantini et al, 2019; Banyoi et al, 2022; Guillette et al, 2022; Jouanneau et al, 2022; Sebastiano et al, 2023). Toxicity estimates based on lab experiments are similar for rodents and birds; for both vertebrate classes, perfluoroalkane sulfonic acids (PFSAs) tend to be more toxic than perfluoroalkyl carboxylic acids (PFCAs) at similar carbon-chain lengths, and 8-carbon compounds tend to be more toxic than shorter molecules (Ankley et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: multiple pathways for wildlife and human exposure

Witt,

Gadek,

Cartron

et al. 2023

Preprint

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Per- and polyfluoroalkyl substances (PFAS) threaten human and wildlife health, but their movement through food webs remains poorly understood. Contamination of the physical environment is widespread, but particularly concentrated at military installations. Here we measured 17 PFAS in wild, free-living mammals and migratory birds at Holloman Air Force Base (AFB), New Mexico, USA, where wastewater catchment lakes form biodiverse oases. PFAS concentrations were among the highest ever reported in animal tissues, and high levels have persisted for at least three decades. The hazardous long carbon-chain form, perfluorooctanosulfonic acid (PFOS), was most abundant, with liver concentrations averaging tens of thousands of ng/g wet weight (ww), reaching as high 97,000 ng/g (ww) in a 1994 specimen of white-footed mouse (Peromyscus leucopus) and 38,000 ng/g ww in a duck, the American wigeon (Mareca americana). Perfluorohexanesulfonic acid (PFHxS) averaged thousands of ng/g ww in the livers of birds and house mice, but one order of magnitude lower in the livers of upland desert rodent species. PFAS levels were strikingly lower at control sites, even for highly mobile migratory species. Tissue concentrations were correlated within individuals, and consistently higher in liver than in muscle or blood. Twenty of 23 vertebrate species sampled at Holloman AFB were heavily contaminated, representing multiple trophic levels and microhabitats, and implicating a range of pathways for PFAS spread: ingestion of surface water, sediments, and dust; foraging on aquatic invertebrates and plants by secondary consumers; and preying upon small vertebrates by higher level consumers, including consumption of game species by hunters. Unlike in other aquatic systems, piscivory was not an important pathway of PFAS uptake. In sum, legacy PFAS at a desert wetland have permeated the local food web across a period of decades, severely contaminating resident and migrant animals, and likely exposing humans via game meat consumption and outdoor recreation.

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“…It has been argued that the concentrations at which PFAS show lethal effects in laboratory toxicity tests are unrealistically high and therefore not very environmentally relevant (Banyoi et al, 2022; Sinclair et al, 2020). However, considering the persistency of PFAS, organisms in PFAS‐contaminated areas may be chronically exposed to substantially lower concentrations, potentially causing a wide range of more subtle sublethal effects (ITRC, 2022; Sinclair et al, 2020).…”

Section: Ecotoxicity Of Pfasmentioning

confidence: 99%

Research Priorities for the Environmental Risk Assessment of Per‐ and Polyfluorinated Substances

Gkika,

Xie,

van Gestel

et al. 2023

Enviro Toxic and Chemistry

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Per‐ and polyfluorinated substances (PFAS) are a group of thousands ubiquitously applied persistent industrial chemicals. The field of PFAS environmental research is developing rapidly, but suffers from substantial biases towards specific compounds, environmental compartments, and organisms. The aim of this perspective was therefore to highlight current developments, and to identify knowledge gaps and subsequent research needs that would contribute to a comprehensive environmental risk assessment for PFAS. To this end, we consulted the open literature and databases, revealing that knowledge of the environmental fate of PFAS is based on the analysis of less than 1% of the compounds categorized as PFAS. Moreover, soils and suspended particulate matter (SPM) remain largely understudied. PFAS bioavailability, bioaccumulation and food web transfer studies also focus on a very limited number of compounds and are biased towards aquatic biota. Fish are predominantly studied, while aquatic invertebrates and macrophytes are included less frequently. The available ecotoxicity data revealed that only a few PFAS have been well‐studied for their environmental hazards, and that PFAS ecotoxicity data are strongly biased towards aquatic organisms as well. This emphasizes the need to catch up with ecotoxicity studies in the terrestrial environment. Considering the persistency and bioaccumulation of PFAS, more chronic, multigeneration and community ecotoxicity studies are needed. Finally, we identified the urgent need to unravel the relationship between sorption, bioaccumulation and ecotoxicity on the one hand and molecular descriptors of PFAS chemical structures and physicochemical properties on the other, to enable prediction of exposure, bioaccumulation and toxicity.

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The effects of exposure to environmentally relevant PFAS concentrations for aquatic organisms at different consumer trophic levels: Systematic review and meta-analyses

Cited by 17 publications

References 88 publications

Two for the Price of One: Deriving Per- and Polyfluoroalkyl Substances (PFAS) Fillet and Whole-Body Conversion Equations in Fish

Two for the Price of One: Deriving Per- and Polyfluoroalkyl Substances (PFAS) Fillet and Whole-Body Conversion Equations in Fish

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: multiple pathways for wildlife and human exposure

Research Priorities for the Environmental Risk Assessment of Per‐ and Polyfluorinated Substances

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