Effects of peptide and non-peptide antagonists of angiotensin II receptors on drinking behavior in rats

Alova, L; Stancheva, S; Matsoukas, John; Georgiev, Vasil

doi:10.1016/s0928-4257(99)80154-5

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…This simple, noninvasive testing procedure may be a quick way to screen for reduction of AT 2 R. Similar depression in water intake after dehydration has been reported in rats pretreated with specific antagonists of the AT 2 R (Rowland & Fregly, 1993; Lee et al 1996). The reduced dipsogenic response to Ang II observed in the present study also has been reported in animals treated with a selective AT 2 R antagonist (Alova et al 1999). These results would suggest that both the traditional AT 1 as well as the AT 2 receptor might mediate the effects of angiotensin on water balance.…”

Section: Discussionsupporting

confidence: 90%

“…This viral treatment did not result in any obvious behavioural effects. Use of this 'knockdown' approach yielded similar dipsogenic responses that have been reported in both the AT 2 R knockout mice (Hein et al 1995) and in studies using pharmacological blockers of this receptor subtype (Rowland & Fregly, 1993;Lee et al 1996;Alova et al 1999;Moore et al 2001).…”

Section: Discussionmentioning

confidence: 63%

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Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

Wang

Gallinat

et al. 2004

Experimental Physiology

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Most of our knowledge of the function of the angiotensin type 2 receptor (AT 2 R) has been obtained from transgenic mouse models. The aim of the present study was to investigate the role of the AT 2 R in normotensive Sprague-Dawley (SD) rats by using antisense gene transfer technology to 'knockdown' this specific receptor subtype. A retroviral vector containing full-length AT 2 R antisense cDNA (AT 2 R-AS) was constructed and the effectiveness of the transduction of AT 2 R-AS was studied in vitro. In subsequent in vivo studies, 5-day-old normotensive SD rats received a single intracardiac bolus (25 µl) of AT 2 R-AS viral particles. When animals reached adulthood, direct blood pressure (BP), and both pressor and dipsogenic responses to angiotensin II were investigated. Long-lasting expression of the AT 2 R-AS transcript and a reduction in mRNA and binding of the AT 2 R was observed in vitro. Expression of AT 2 R-AS transcript was maintained for 90 days in heart, kidney, lung and brain, indicating a high degree of transgene transduction in vivo. As adults, systolic BP and the pressor responses to angiotensin were significantly elevated in AT 2 R-AS-treated rats. However, AT 2 R-AS-treated rats displayed significantly reduced dipsogenic responses to both angiotensin and water deprivation. Collectively, these data demonstrate that a single neonatal injection of the retroviral vector containing antisense to the AT 2 receptors in rats results in similar cardiovascular and dipsogenic responses as reported in AT 2 R knockout mice.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 63%

Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

Wang

Gallinat

et al. 2004

Experimental Physiology

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“…For PD 123319, high concentrations have been shown to act non‐specifically by binding to the AT 1 receptor ( Timmermans et al . 1993 , Alova et al . 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Camara¹,

Osborn²

2001

Acta Physiologica Scandinavica

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Intracerebroventricular (ICV) angiotensin (AIl) administration stimulates central AII receptors to induce water consumption in rats. The aim of this study was to determine the role of brain AT1 and AT2 receptors in mediating chronic ICV AII-induced drinking in rats raised on normal or high sodium chloride diets from weaning. Rats were weaned at 21 days of age and placed on normal or high sodium chloride diet for 10-12 weeks. At adulthood, the animals were instrumented with brain lateral ventricular cannulas and femoral arterial catheters. Low dose chronic central AII infusion (20 ng min(-1)) significantly (P < 0.05) increased water intake in both groups of rats when compared with their respective controls of 24 h artificial cerebrospinal fluid infusions. In a separate group of high sodium fed rats, coinfusion of AII with the AT1 receptor antagonist, losartan (0.25 microg min(-1)) or the AT2 receptor blocker, PD 123319 (0.50 microg min(-1)) blocked chronic ICV AII-induced drinking. Upon reinfusion of AII water intake increased above control. Following the cessation of AII infusions, water intake returned to values not significantly different from control (P > 0.05). In contrast, in the normal sodium fed rats losartan, but not PD 123319, blocked the AII-mediated water intake. The data demonstrate that in high sodium chloride fed rats AII stimulates both central AT1 and AT2 receptors to induce drinking, while in the normal sodium chloride fed rats the peptide activates the drinking response primarily by stimulation of central AT1 receptors.

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“…These results showed that both brain AT1 and AT2 receptors are involved in dehydration-induced drinking. 18,19 Under conditions of chronic AT1 receptor block, it is possible that the endogenous Ang II level is not suffi cient for the activation of nonblocked AT2 receptors and accomplishment of the dipsogenic effect. Moreover, while the dipsogenic effect elicited by AT1 receptor activation is related to release of vasopressin, AT2 receptors exerted their dipsogenic effect without affecting vasopressin plasma concentration.…”

Section: Discussionmentioning

confidence: 99%

Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

Pechlivanova

Stoynev

2013

Folia Medica

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Effects of peptide and non-peptide antagonists of angiotensin II receptors on drinking behavior in rats

Cited by 10 publications

References 21 publications

Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

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Effects of peptide and non-peptide antagonists of angiotensin II receptors on drinking behavior in rats

Cited by 10 publications

References 21 publications

Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

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Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning