Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

Pechlivanova, Daniela; Stoynev, Alexander

doi:10.2478/folmed-2013-0029

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Our earlier data showed that blockade of brain AT2 receptors produced a pronociceptive effect in a visceral pain model [30]. Further, we have shown that the partial AT2 agonist was able to induce antinociception after acute treatment, whereas in a chronic regimen it can reverse this effect [31]. We can speculate that the stronger antinociceptive effect of NVK in female SHRs is a result of their increased non-classical RAS and reduced ratio of AT1/AT2 receptors, making females more susceptible to treatment with AT2 ligands [1,2,22,23].…”

Section: Resultsmentioning

confidence: 84%

Evidence for biological effects of the hexapeptide novokinin

E. Pakataridis,

S. Chelmis,

V. Assenov

et al. 2023

JCTM

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The imbalance of the endogenous renin-angiotensin system is one of the mechanisms involved not only in the hypertension but also in the development of behavioral abnormalities. Activation of angiotensin AT2 and Mas receptors is considered a protective and balancing arm in the renin-angiotensin system, and the synthesis and characterization of selective agonists of these receptors is a promising direction for chemical and pharmacological research.The aim of the present study was to elucidate the effects of intracerebroventricular infusion of the hexapeptide Novokinin, a selective angiotensin AT2 receptor agonist, on anxiety, exploratory behavior, nociception, working and spatial memory in spontaneously hypertensive female rats.The following battery of tests was used: Open Field and Elevated Plus Maze to study exploration and anxiety-like behaviors, object recognition, T-maze for working and spatial memory, and paw pressure for nociception. Novokinin was infused intracerebroventricularly using osmotic minipumps and a stereotaxically implanted brain kit in adult female spontaneous hypertensive rats. All tests were performed twice: at the end of the infusion and three months later. The rats are characterized by hyperactivity, reduced levels of anxiety and impaired spatial memory, which are associated with the strain's inherent impulsive behavior. Novokinin-treated rats showed reduced anxiolysis and hyperactivity as well as increased pain threshold compared to controls. The peptide improves adaptation to the new environment and spatial memory without changes in novel object recognition.In summary, chronic stimulation of brain AT2 receptors by the peptide novokinin improves cognitive behavior and memory and normalizes anxiety-like behavior in spontaneously hypertensive female rats.

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Section: Resultsmentioning

confidence: 84%

Evidence for biological effects of the hexapeptide novokinin

E. Pakataridis,

S. Chelmis,

V. Assenov

et al. 2023

JCTM

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“…Pharmacological data showed that MAPK is specific for salt intake, as its inhibition suppresses sodium appetite without affecting thirst. Daniels et al [ 23 ] showed that ANG II stimulates thirst and salt intake via MAPK pathway, whereas the combined treatment with aldosterone and ANG II induces sodium appetite via IP3 signaling. In addition, aldosterone might increase the responsiveness of OVLT neurons to ANG II by reducing the activation of MAPK signaling in some neurons and increasing IP3 in others.…”

Section: Discussionmentioning

confidence: 99%

“…To better explain the role of angiotensin II in controlling water intake and sodium appetite, some experimental models have been discussed. For instance, the intracerebroventricular (ICV) infusion of ANG II increases water intake and sodium appetite, and this effect is abolished by the AT 1R antagonist losartan [ 23 , 24 ], but not AT 2R antagonism [ 25 ]. It has been reported that ANG II stimulates water intake and salt ingestion through two separate signaling pathways: (1) Protein Kinase C (PKC), a G protein-dependent pathway, and (2) Mitogen-Activated Protein Kinase (MAPK), a G protein-independent pathway.…”

Section: Introductionmentioning

confidence: 99%

Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review

Iovino

Messana

Lisco

et al. 2021

IJMS

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Sodium appetite is an innate behavior occurring in response to sodium depletion that induces homeostatic responses such as the secretion of the mineralocorticoid hormone aldosterone from the zona glomerulosa of the adrenal cortex and the stimulation of the peptide hormone angiotensin II (ANG II). The synergistic action of these hormones signals to the brain the sodium appetite that represents the increased palatability for salt intake. This narrative review summarizes the main data dealing with the role of mineralocorticoid and ANG II receptors in the central control of sodium appetite. Appropriate keywords and MeSH terms were identified and searched in PubMed. References to original articles and reviews were examined, selected, and discussed. Several brain areas control sodium appetite, including the nucleus of the solitary tract, which contains aldosterone-sensitive HSD2 neurons, and the organum vasculosum lamina terminalis (OVLT) that contains ANG II-sensitive neurons. Furthermore, sodium appetite is under the control of signaling proteins such as mitogen-activated protein kinase (MAPK) and inositol 1,4,5-thriphosphate (IP3). ANG II stimulates salt intake via MAPK, while combined ANG II and aldosterone action induce sodium intake via the IP3 signaling pathway. Finally, aldosterone and ANG II stimulate OVLT neurons and suppress oxytocin secretion inhibiting the neuronal activity of the paraventricular nucleus, thus disinhibiting the OVLT activity to aldosterone and ANG II stimulation.

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Protective effects of losartan on some type 2 diabetes mellitus-induced complications in Wistar and spontaneously hypertensive rats

et al. 2020

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Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

Abstract: Chronic treatment with selective angiotensin receptor ligands modifies water-salt balance in rats through changes both in renal excretory function and ingestive behaviors.

Cited by 5 publications

References 24 publications

Evidence for biological effects of the hexapeptide novokinin

Evidence for biological effects of the hexapeptide novokinin

Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review

Protective effects of losartan on some type 2 diabetes mellitus-induced complications in Wistar and spontaneously hypertensive rats

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