Effects of pentoxifylline in Adriamycin-induced renal disease in rats

Usta, Yusuf; Ismailoglu, Ugur B.; Bakkaloğlu, Ayşı̇n; Orhan, Dicle; Beşbaş, Nesrin; Şahin-Erdemli, İnci; Özen, Seza

doi:10.1007/s00467-004-1538-5

Cited by 34 publications

(23 citation statements)

References 14 publications

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“…DOX‐treatment significantly increased serum creatinine, BUN, NO, urinary albumin, and NAG. Our results are in good agreement with those previously reported 36–38. However, treatment with AG (200 or 400 mg/kg) resulted in a significant decrease of these parameters in DOX‐treated animals, thus offering considerable protection against nephrotoxicity.…”

Section: Discussionsupporting

confidence: 93%

The protective effect of aminoguanidine on doxorubicin‐induced nephropathy in rats

Abo-Salem

2012

J Biochem & Molecular Tox

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Reactive oxygen species and cytokines have been implicated in the nephrotoxicity induced by doxorubicin. The goal of the present study was to determine protective effect of aminoguanidine on doxorubicin-induced nephrotoxicity in rats. Different groups of male Wistar rats received doxorubicin (67.75 mg/kg/i.p./2 days), aminoguanidine alone and aminoguanidine (200 and 400 mg/kg/i.p./30 days) prior to doxorubicin, respectively. Doxorubicin significantly increased serum creatinine (505%), blood urea nitrogen (333%), nitric oxide (406%), and plasma tumor necrosis factor-alpha (706%) as well as urinary albumin (452%) and N-acetyl-β-D-glucosaminidase (415%) compared to control. Moreover, renal glutathione (334%), superoxide dismutase (283%), and catalase (513%) were significantly reduced accompanied with elevation in renal malondialdehyde compared to control. Pretreatment with aminoguanidine mitigated such changes in all mentioned parameters. Histopathological changes showed that doxorubicin-caused significant structural damages to kidneys that were reduced with aminoguanidine. Results indicate that reactive oxygen species and cytokines are involved in doxorubicin-induced nephrotoxicity, which can be reduced by aminoguanidine.

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Section: Discussionsupporting

confidence: 93%

The protective effect of aminoguanidine on doxorubicin‐induced nephropathy in rats

Abo-Salem

2012

J Biochem & Molecular Tox

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“…In the present study, DOX treatment caused a significant increase in TBARS levels and a significant decrease in GSH and CAT levels, when compared with the control group. These findings are in agreement with previous reports [25,29]. TBARS, a stable metabolite of the free radical mediated lipid peroxidation cascade, is widely used as a marker of oxidative stress and lipid layer destruction [30].…”

Section: Discussionsupporting

confidence: 93%

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Oğuz¹,

Beytur²,

Sarihan³

et al. 2016

CIM

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Purpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats.Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined.Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage.Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted.

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“…22 PTX was shown to prevent apoptosis in methotrexate, Adriamycin and cisplatin-induced nephropathies in various experimental studies. 13,22,23 In our study, we showed that PTX significantly ameliorates GEN-induced apoptosis. These data support the hypothesis that PTX protects kidney tissue against apoptosis caused by GEN treatment.…”

Section: Discussionmentioning

confidence: 76%

“…11 Pentoxifylline (PTX) is a methylxanthine derivative, which has well-known renoprotective effects through the prevention of free radical formation and inhibition of programmed cell death. [12][13][14] Recently, PTX has been shown to be protective in amikacin and GEN-induced nephrotoxicity. 15,16 In amikacin-induced nephrotoxicity, it has been shown that PTX has renoprotective effects through antioxidative mechanisms and that was not studied in GEN-induced nephrotoxicity model.…”

Section: Introductionmentioning

confidence: 99%

Effects of pentoxifylline on gentamicin-induced nephrotoxicity

Kasap¹,

Türkmen²,

Kıray³

et al. 2013

Renal Failure

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We aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200-250 g) were included and four groups were formed. The first one was the control group (n:5). The rats in other groups (n:7 for each) received 50 mg/kg twice daily intraperitoneal (i.p.) PTX, 100 mg/kg i.p. GEN and both GEN and PTX at the same doses for consecutive 8 days, respectively. Rats were weighed both at the beginning and end of the study. After the last dose, 24-hour urines were collected and the rats were sacrificed. Blood samples and kidney tissues were obtained for biochemical, histological, oxidative stress, and apoptotic parameters. Body weights were similar in all groups at the beginning of the study. Rats in GEN group had significant weight loss, tubular damage, and increased apoptosis, while GEN + PTX group had significantly better outcomes. Scr, urinary protein/creatinine, and TBARS levels were significantly higher and Ccr and SOD levels were significantly lower in GEN and GEN + PTX groups in comparison to control and PTX groups, but the levels were similar between GEN and GEN + PTX groups. In conclusion, concomitant administration of PTX provides renoprotection via suppressing apoptosis in GEN-induced nephropathy.

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Effects of pentoxifylline in Adriamycin-induced renal disease in rats

Cited by 34 publications

References 14 publications

The protective effect of aminoguanidine on doxorubicin‐induced nephropathy in rats

The protective effect of aminoguanidine on doxorubicin‐induced nephropathy in rats

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Effects of pentoxifylline on gentamicin-induced nephrotoxicity

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