Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening

Abstract

Objective: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the morphologic quality of embryos and the pregnancy rate. In this study, we investigated whether paternal age affected the euploidy rate. Methods: This study was performed using the medical records of patients who underwent in vitro fertilization (IVF) procedures with preimplantation genetic screening (PGS) from January 2016 to August 2017 at a single center. Based on their morphological grade, embryos were categorized as good-or poor-quality blastocysts. The effects of paternal age were elucidated by adjusting for maternal age. Results: Among the 571 total blastocysts, 219 euploid blastocysts were analyzed by PGS (38.4%). When the study population was divided into four groups according to both maternal and paternal age, significant differences were only noted between groups that differed by maternal age (group 1 vs. 3, p= 0.031; group 2 vs. 4, p= 0.027). Further analysis revealed no significant differences in the euploidy rate among the groups according to the morphological grade of the embryos. Conclusion: Paternal age did not have a significant impact on euploidy rates when PGS was performed. An additional study with a larger sample size is needed to clarify the effects of advanced paternal age on IVF outcomes.

The effects of age onDNAfragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution

“…The correlation coefficients published so far exhibit a relatively wide range, most often between .10 and .55 depending on the method used and the population studied. [19][20][21][22][23]24,25 They are usually slightly lower than those observed in this study. This may be due to the fact that city policemen in the performance of their professional duties are exposed to exhaust gases from road transport for extended periods.…”

“…A significant positive correlation was found between age and %DFI. The correlation coefficients published so far exhibit a relatively wide range, most often between .10 and .55 depending on the method used and the population studied 19‐23,24,25 . They are usually slightly lower than those observed in this study.…”

Embryos derived from donor or patient oocytes are not different for in vitro fertilization outcomes when PGT allows euploid embryo selection: a retrospective study

“…Some of this data was collect for most of the patients; however, these external factors were not the focus of the manuscript and should be analyzed in future studies with a specific focus on these factors. Moreover, other studies and reports, in which the patient cohort was made up of only oocyte donors, the pregnancy rate was around 50% [28,29]. Also, the aneuploidy rate could be around 25%, and, depending on the age of the sperm donor, exceed 60% [9, 10, 30].…”

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

“…In contrast, Carrasquillo et al evaluated 6934 embryos from 1202 IVF/ICSI egg donor cycles using blastocyst biopsy and found no relationship between APA and embryo aneuploidy [18]. Similarly, a recent South Korean study found no association between paternal age and embryo aneuploidy, whereas significant differences were noted between groups that differed by maternal age [67]. The lack of consistent findings on APA and embryo aneuploidy is likely in part due to small sample sizes and differing methods of genetic testing.…”