Effects of parenteral nutrition of ω-3 polyunsaturated fatty acid, arginine and glutamine on cellular immune status of patients following liver cancer surgery

Abstract

Purpose: To study the effects of parenteral nutrition (TPN), ω-3 polyunsaturated fatty acid (PUFA), Larginine (Arg), and glutamine on cellular immunity of patients who 05). IL-6 in group E was lower than that in any of the other four groups (p < 0.05). IL-10 in group A was lower than that in groups B, C and D, but lower than in group E (p < 0.05). The levels of TNF-a in groups B and C were lower than those in group A, but higher than that in group E (p < 0.05) but lower than in group D. IgA in group E was higher than in the other groups (p < 0.05), while IgM level in group E was lower than in groups A, B and C (p < 0.05

ω‐3 Fatty‐Acid Enriched Parenteral Nutrition in Hospitalized Patients: Systematic Review With Meta‐Analysis and Trial Sequential Analysis

“…A total of 49 studies with 3641 patients were included in the review and meta‐analysis (Figure and Table ) …”

Does inclusion of bioactive n-3 PUFAs in parenteral nutrition benefit postoperative patients undergoing liver surgery? A systematic review and meta-analysis of randomised control trials

“…Two of the RCTs were published in Chinese 49 50. In five studies, all patients underwent hepatectomy 49 51–54. In the other three studies, all participants were status post liver transplantation 47 50 55.…”

“…In the other three studies, all participants were status post liver transplantation 47 50 55. Except for two studies by the product of Fresenius Kabi containing soy oil-medium chain triglycerides—olive oil—fish oil lipid,52 55 the remaining six studies used a product of n-3 PUFAs, Omegaven. The application duration of n-3 PUFA for liver surgery patients was 5 days in three RCTs,51 53 54 6 days in the other three RCTs,49 50 52 and 2 and 7 days in the remaining two studies 47 55.…”

“…Except for two studies by the product of Fresenius Kabi containing soy oil-medium chain triglycerides—olive oil—fish oil lipid,52 55 the remaining six studies used a product of n-3 PUFAs, Omegaven. The application duration of n-3 PUFA for liver surgery patients was 5 days in three RCTs,51 53 54 6 days in the other three RCTs,49 50 52 and 2 and 7 days in the remaining two studies 47 55. Among these included RCTs, the postoperative time of blood test was the third day in four articles,49 51 54 55 the second day in two articles,47 50 the sixth day in one article53 and unknown in the remaining one study 52 Online supplemental table 1.…”

“…The application duration of n-3 PUFA for liver surgery patients was 5 days in three RCTs,51 53 54 6 days in the other three RCTs,49 50 52 and 2 and 7 days in the remaining two studies 47 55. Among these included RCTs, the postoperative time of blood test was the third day in four articles,49 51 54 55 the second day in two articles,47 50 the sixth day in one article53 and unknown in the remaining one study 52 Online supplemental table 1. summarises the detailed characteristics of the included RCTs.…”