Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

Kumar, Pradeep; Kant, Upadhyay Ravi

doi:10.30574/wjarr.2020.6.1.0039

World J. Adv. Res. Rev.

2020

DOI: 10.30574/wjarr.2020.6.1.0039

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Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

Pradeep Kumar¹,

Upadhyay Ravi Kant²

Abstract: Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

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Effect of Purified Paper Wasp <i>Ropalidia marginata</i> Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

Sharma,

Upadhyay

2023

AER

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In the present, investigation effects of sub-lethal dose of purified paper wasp Ropalidia marginata venom toxins were evaluated on important metabolic enzymes i.e. ALP ACP, GPT, GOT, LDH, and AchE enzyme activity in serum, liver, and gastrocnemius muscles of albino mice. Alkaline phosphatase was found to be increased up to 119.9% at the 6 th hr of the toxin injection in comparison to control. This elevation may be due to cytolysis. Maximum increase i.e., 153.33% level of glutamate pyruvate transaminase (GPT) was found at 6 hrs of 40% of 24-h LD 50 treatment while it was found to be 151.1% at 6 hrs of 24 hr 80% of LD 50 , venom injection. A significant elevation was observed in LDH activity in serum, liver, and muscles, while the activity of AchE was decreased in serum, liver, and gastrocnemius muscles of albino mice after injecting the sub-lethal dose of Ropalidia marginata venom. This increase in the activity of LDH produces liver damage, massive disintegration and necrosis of hepatic cells. This elevation in LDH level led to a significant increase in the glucose catabolism and elevated oxidative stress in muscle and liver cells. It also displays insufficient oxygen supply and consequently leads to cell death. In experimental animals, venom toxin treatment decreased AchE level, and animals showed muscular paralysis. When mice were treated with 40% and 80% of 24-h LD 50 of purified venom caused a significant (p < 0.05) elevation in the level of ACP, GOT, GPT, and LDH while the reduction in ALP and AChE level. Present study will be useful in the development of prototypes for study of pharmacological and therapeutic effects of various venom toxins. For this purpose structure activity relationship of enzyme and venom toxin, its due interaction to various metabolic enzymes and receptors must be explored.

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Effect of Purified Paper Wasp <i>Ropalidia marginata</i> Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

Sharma,

Upadhyay

2023

AER

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Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

Abstract: Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

Cited by 1 publication

References 20 publications

Effect of Purified Paper Wasp <i>Ropalidia marginata</i> Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

Effect of Purified Paper Wasp <i>Ropalidia marginata</i> Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

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Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

Abstract: Effects of paper wasp (Polistes flavus) venom toxins on lactic dehydrogenase (LDH) and acetyl cholinesterase (AChE) activity in blood serum, liver and muscles of albino mice

Cited by 1 publication

References 20 publications

Effect of Purified Paper Wasp &lt;i&gt;Ropalidia marginata&lt;/i&gt; Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

Effect of Purified Paper Wasp &lt;i&gt;Ropalidia marginata&lt;/i&gt; Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

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Effect of Purified Paper Wasp <i>Ropalidia marginata</i> Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

Effect of Purified Paper Wasp <i>Ropalidia marginata</i> Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice