Effects of papaverine and hemorrhage on renin secretion in the nonfiltering kidney

Witty, RT; Davis, JO; Johnson, Julian; Prewitt, Russell L.

doi:10.1152/ajplegacy.1971.221.6.1666

Cited by 59 publications

(33 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies in the nonfiltering kidney suggest that hemorrhage may provide a multifactorial stimulus for renin release (9 Although Romero et al (11) found that inhibition of prostaglandin synthesis abolished the renin response to hemorrhage in the conscious rabbit, this was not found to be the case in the present study in the anesthetized dog. Hypotensive hemorrhage significantly These results confirm the findings of earlier studies in the dog from our laboratory suggesting that renin release during hemorrhage is not dependent on intact prostaglandin synthesis (12,23).…”

Section: Discussioncontrasting

confidence: 84%

See 1 more Smart Citation

Mechanisms of Renin Secretion during Hemorrhage in the Dog

1979

View full text Add to dashboard Cite

A B S T R A C T The importance of renal perfusion pressure (RPP), the sympathetic beta adrenergic nervous system and renal prostaglandins (PG) on renin release during a uniform 15-17% reduction in blood pressure by hemorrhage (HH) was studied systematically in anesthetized dogs. All groups of animals had similar decrements in systemic and renal hemodynamics with HH. In control dogs (n = 7), both plasma renin activity (PRA, 4.1-9.0 ng angiotensin I/ml per h, P < 0.05) and renin secretory rate (RSR, 26-228 ng/ml per h min, P < 0.005) increased significantly with HH. This increase in renin release during HH was not abolished by any single maneuver alone including beta adre nergic blockade with d,l-propranolol (n = 6), renal PG inhibition with indomethacin (n = 7), or control of RPP (n = 6). However, when beta adrenergic blockade was combined with control of RPP (n = 7) during HH, neither PRA (1.9-2.7 ng/ml per h, NS) nor RSR (16-53 ng/ml per h min, NS) increased significantly. Similarly, a combination ofbeta adrenergic blockade and PG inhibition (n = 6) also abolished the increase in PRA (1.5-1.4 ng/ml per h, NS) and RSR (14-55 ng/ml per h*min, NS) 75216.

show abstract

Section: Discussioncontrasting

confidence: 84%

“…Previous investigations of the renin response to hemorrhage have stressed the importance ofthe macula densa and renal nerve activity as important stimuli to renin release (9). The experimental model used in these earlier studies was that of the denervated, nonfiltering kidney (10).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Renin Secretion during Hemorrhage in the Dog

1979

View full text Add to dashboard Cite

show abstract

“…In contrast to this, Ta rawa and Vander [40] found no effect on renin release after vasodilation by acetylcho line. Similar results were obtained by Willy et al [49] with papaverin. Other authorsWernig et al [48] and Varkarakis et al [44] -attributed the stimulation of the reninangiotensin system by prostaglandins to changes in sodium concentration in the area of the macula densa.…”

Section: Discussionsupporting

confidence: 90%

Influence of Prostaglandins A1, E1, E2, and F2α on Renal Blood Flow and Plasma Renin Activity

Neumayer¹,

Wagner²,

Schuhze³

et al. 1982

Kidney Blood Press Res

View full text Add to dashboard Cite

The effects of different prostaglandins (PG) on serial determinations of renal blood flow (RBF), mean arterial blood pressure (MABP), renal vascular resistance (RVR) and renin release were investigated in the conscious, chronically instrumented dog. 2 months after right-sided nephrectomy, female beagle dogs (n=6) were implanted with an electromagnetic flow probe and an inflatable pneumatic cuff around the left renal artery, and a catheter was inserted into the aorta above the renal artery. In repeated experiments, different prostaglandins (PGA_1, E₁, E₂ and F_2α) were infused above the renal artery at increasing doses (infusion time 15 min, doses 0.03–1.0µg min^-1 kg^-1). Lower and medium doses induced an increase of RBF, which returned to or were slightly below control levels with higher doses. PGA, appeared to be the most potent vasodilator with a significant hypotensive activity and the greatest augmentation of RBF. Simultaneously, renin release was most pronounced by PGA,.

show abstract

“…In contrast, groups 2 and 3 did not have an increased renal blood flow following intrarenal arachidonic acid infusion (3 + 2, 4 +1 ml./min, respectively). These findings indicated that prostaglandin synthesis was inhibited in groups 2 and 3. papaverine have previously been reported to functionally isolate the macula densa mechanism of renin release (Witty et al 1971). This technique was used in our study to determine if prostaglandin synthesis is required for the macula densa stimulated release of renin following partial occlusion of the abdominal aorta.…”

Section: Resultsmentioning

confidence: 99%

“…In kidneys so treated, the only remaining mechanism for renin release was the macula densa chemoreceptor as demonstrated by Witty et al (1971).…”

Section: Animal Preparationmentioning

confidence: 95%

Control of canine renin release: macula densa requires prostaglandin synthesis.

Gerber¹,

Nies²,

Olsen³

1981

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The macula densa mechanism of renin release was functionally isolated in uninephrectomized, anaesthetized dogs by producing renal denervation, /1-adrenoceptor blockade, and maximum renal vasodilation with an infusion of papaverine into the renal artery.2. A suprarenal aortic clamp was adjusted to reduce renal perfusion pressure by 50 % which resulted in a 90 % reduction in urinary sodium excretion and a two-to threefold increase in plasma renin activity within 10 min. 3. Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise in plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved.4. We conclude that the macula densa mechanism of renin release is blocked by inhibition of prostaglandin synthesis.

show abstract

Effects of papaverine and hemorrhage on renin secretion in the nonfiltering kidney

Cited by 59 publications

References 0 publications

Mechanisms of Renin Secretion during Hemorrhage in the Dog

Mechanisms of Renin Secretion during Hemorrhage in the Dog

Influence of Prostaglandins A<sub>1,</sub> E<sub>1</sub>, E<sub>2</sub>, and F<sub>2α</sub> on Renal Blood Flow and Plasma Renin Activity

Control of canine renin release: macula densa requires prostaglandin synthesis.

Contact Info

Product

Resources

About