Mechanisms of Renin Secretion during Hemorrhage in the Dog

Henrich, William L.; Schrier, Robert W.; Berl, Tomás

doi:10.1172/jci109427

Cited by 35 publications

(13 citation statements)

References 23 publications

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“…Since furosemide administration has been reported to stimulate both the baroreceptor and the macula densa mechanism of renin release (Corsini, Hook & Bailie, 1975), prostaglandin synthesis appears necessary for both mechanisms of renin release. Our data also confirm the conclusions of Henrich, Schrier & Berl (1979) that prostaglandins may mediate both the baroreceptor and macula densa mechanisms of renin release.…”

Section: Resultssupporting

confidence: 90%

Control of canine renin release: macula densa requires prostaglandin synthesis.

Gerber¹,

Nies²,

Olsen³

1981

The Journal of Physiology

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SUMMARY1. The macula densa mechanism of renin release was functionally isolated in uninephrectomized, anaesthetized dogs by producing renal denervation, /1-adrenoceptor blockade, and maximum renal vasodilation with an infusion of papaverine into the renal artery.2. A suprarenal aortic clamp was adjusted to reduce renal perfusion pressure by 50 % which resulted in a 90 % reduction in urinary sodium excretion and a two-to threefold increase in plasma renin activity within 10 min. 3. Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise in plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved.4. We conclude that the macula densa mechanism of renin release is blocked by inhibition of prostaglandin synthesis.

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Section: Resultssupporting

confidence: 90%

Control of canine renin release: macula densa requires prostaglandin synthesis.

Gerber¹,

Nies²,

Olsen³

1981

The Journal of Physiology

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“…Urinary sodium excretion was also comparable in this group in innervated and denervated kidneys suggesting that sodium delivery to the distal nephron was similar, and thus that the macula densa stimulation was comparable. In view of the continuing controversy regarding the physiologic role prostaglandins play in Dissociation (23)(24)(25)(26). Thus, while it should be acknowledged that the baroreceptor (23,26,47) and macula densa (48) pathways to renin release may be prostaglandin-dependent in the dog, the present results clearly show that renin secretion may occur in response to enhanced endogenous renal sympathetic nerve activity via pathways independent of the prostaglandin system.…”

Section: Discussionmentioning

confidence: 48%

“…In these dogs the magnitude of the increase in renin secretion from innervated and denervated kidneys were similar. This finding was predictable since multiple pathways to renin secretion (arterial baroreceptor, sympathetic nerves in innervated kidneys, and macula densa) are likely to be activated during a hypotensive stress of this type (23)(24)(25)(26). Urinary sodium excretion was also comparable in this group in innervated and denervated kidneys suggesting that sodium delivery to the distal nephron was similar, and thus that the macula densa stimulation was comparable.…”

Section: Discussionmentioning

confidence: 54%

“…Further, the beneficial effect of prostaglandin inhibition on blood pressure (1,22) during endotoxemia has not been studied with respect to the renal hemodynamic consequences of such a maneuver. Finally, the exact importance of prostaglandins in renin secretion during stimulation of the sympathetic nervous system stress has been a controversial subject (23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

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Dissociation of systemic and renal effects in endotoxemia. Prostaglandin inhibition uncovers an important role of renal nerves.

Henrich¹,

Hamasaki²,

Said³

et al. 1982

J. Clin. Invest.

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A B S T R A C T To elucidate the mechanisms responsible for systemic and renal hemodynamic changes in early endotoxemia, the roles of prostaglandins (PG) and renal nerves were investigated. Endotoxin (E, 3 ag/kg i.v.) was given to two groups of anesthetized dogs that had undergone unilateral renal denervation: Group I (n = 9) E only; Group II (n = 11) E + indomethacin (10 mg/kg i.v.) or meclofenamate (5 mg/kg i.v.). A third group of dogs (Group III, n = 5) received indomethacin (10 mg/kg i.v.) only. 1 h after E in group I dogs, mean arterial pressure (MAP) decreased from 126 to 94 mm Hg (P < 0.001), and prostacyclin (6-keto-Fla metabolite, PGI2) increased (from 0.64 to 2.08 ng/ml, P < 0.005). Glomerular filtration rate (GFR) and renal blood flow (RBF) declined comparably both in innervated and denervated kidneys. In marked contrast, group II dogs had a stable MAP (136-144 mm Hg, NS) and no increase in PGI2 levels. Plasma renin activity (0.7-2.5 ng/ml per h, P < 0.005) increased, and renin secretion was greater in innervated compared with denervated kidneys (255 vs. 74 U/min, P < 0.01) in these PG-inhibited dogs. In addition, denervated kidneys in group II dogs had a greater GFR (42 vs. 34 ml/min, P < 0.01) and RBF (241 vs. 182 ml/min, P < 0.01) than innervated kid- renin activity or PGI2 during the study. These results suggest that PGI2 mediates the systemic hypotension of early endotoxemia in the PG-intact animal. Moreover, PG inhibition uncovers an important effect of E to increase efferent renal nerve activity with a consequent decline in GFR and RBF independent of changes in MAP. Finally, the results demonstrate that renal nerves are important stimuli to renin secretion in early endotoxemia via pathways that are PG-independent.

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“…Isoproterenol is thought to stimulate renin release from juxtaglomerular cells in the kidney by activating b-adrenergic receptors that stimulate the cAMP pathway (Aldehni et al, 2011). Hemorrhage and water deprivation activate renin release primarily through activation of the sympathetic nervous system (Blair et al, 1991;Blair et al, 1997;Castrop et al, 2010) although other factors, such as alterations in renal perfusion pressure, may also play a role (Henrich et al, 1979). The increase in renin in turn increases plasma Ang II levels.…”

Section: Introductionmentioning

confidence: 99%