Effects of "Pacatal" on Symptoms in Chronic Psychotic Female In-patients

Mitchell, Pam; Sykes, Peter; King, Anna C.

doi:10.1136/bmj.1.5012.204

Cited by 25 publications

(6 citation statements)

References 5 publications

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“…Even comparatively large doses (4 to 6 capsules at night) had had no satisfactory sedative effect. Similar noisy and unrestful incidents have been mentioned by Mitchell, Sykes and King (1957).…”

Section: The Ataractic Drugssupporting

confidence: 79%

Some Reflections on Ataractics

Eddie

1958

Int J Clinical Practice

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Section: The Ataractic Drugssupporting

confidence: 79%

Some Reflections on Ataractics

Eddie

1958

Int J Clinical Practice

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“…17 There are several reports of hepatotoxicity associated with reactions to other phenothiazine derivatives. Prochlorperazine, 37 · 38 mepazine, 39 and trifluoroperazine 40 all have been incriminated in several instances of jaundice, similar in type to that induced by chlorpromazine. In an ex tensive experience with the use of promazine, we have seen no instances of jaundice or other liver damage, although reports of promazine-referred jaundice have appeared in the literature.…”

Section: Clinicalmentioning

confidence: 99%

Clinical and Laboratory Manifestations of Hepatotoxicity

Zimmerman

1963

Annals of the New York Academy of Sciences

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“…1 Hsdass et al (1974) 2 Rudenko u. Lepskhin (1979, S. 44-49) 3 Müller et al (1969) 4 Bsttegsy et al (1977) 5 Gross u. Lsngner (1970) 6 Mindhsm (1978 7 Mitchell et al (1957) 8 Oldhsm u. Bott (1971 Obwohl die Angaben anderer Autoren hinsichtlich der Häufigkeit von Temperaturerhöhungen sehr unterschiedlich sind, bewegen sich die Zahlen ftir Clozapin doch alle über 10% (bis 55 %), ftir andere Neuroleptika unter 10% (s. Tab. 6).…”

Section: C) Kreislaufunclassified

Wirkungen der Neuroleptika auf die Leberfunktion, das blutbildende System,den Blutdruck und die Temperaturregulation

Bauer

1983

Pharmacopsychiatry

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The frequency of disturbances of the liver function, of leucopoiesis, blood pressure and temperature regulation under clozapine in comparison with perazine and haloperidol in 478 patients (partly being treated repeatedly) was investigated by means of case histories of the Psychiatric Clinic of Tübingen from October 1974 up to June 1978. Within the time of the investigation no case of jaundice arose, however non-symptomatic increases of the liver values could be observed. The three drugs did not differ in this respect. Within the time of the investigation no case of agranulocytosis was observed. Only one leucopenia under clozapine, one under perazine, and six under haloperidol occurred. Concerning cardio-vascular effects of the neuroleptic medication, in 4.1% of the patients under clozapine therapy, 4.3% under haloperidol therapy and 10.3% under perazine therapy hypotension could be observed. Under clozapine 15.2% of the patients showed a rise of temperature, under perazine 3.2% and under haloperidol 2.8% of the patients. 83.3% of cases with elevated temperature under clozapine occurred during the first two weeks of treatment.

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Effects of "Pacatal" on Symptoms in Chronic Psychotic Female In-patients

Cited by 25 publications

References 5 publications

Some Reflections on Ataractics

Some Reflections on Ataractics

Clinical and Laboratory Manifestations of Hepatotoxicity

Wirkungen der Neuroleptika auf die Leberfunktion, das blutbildende System,den Blutdruck und die Temperaturregulation

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