Clinical and Laboratory Manifestations of Hepatotoxicity

Zimmerman, Hyman J.

doi:10.1111/j.1749-6632.1963.tb57096.x

Cited by 69 publications

(31 citation statements)

References 94 publications

(52 reference statements)

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“…It may be noted that a significant rise in both tissue and serum level seems to indicate a possible subtle disturbance taking place in the biliary secretion and hepatic dysfunction of animals. (Zimmerman, 1978). Earlier, Dikshith et al (1989) reported similar observations in rats exposed to pesticides hexachlorocyclohexane (HCH) and Chlorpropham (CIPC).…”

Section: Discussionsupporting

confidence: 62%

Ninety-Day Toxicity and One-Generation Reproduction Study in Rats Exposed to Allethrin-Based Liquid Mosquito Repellent

Srivastava

Srivastava²,

Raizada³

2006

J. Toxicol. Sci.

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-Rats exposed to liquid mosquito repellent (LMR) containing allethrin (3.6% w/w) 8-hrs/ day for a period of ninety days did not produce any signs of toxicity or death. Significant increases in relative weight of liver and adrenal in males, brain and thyroid in females were observed. No significant changes were noticed in clinical enzyme profile, gonadal enzymes and histopathology of vital organs except mild changes in the activities of liver and serum alkaline phosphates (ALP), testicular glucose-6-phosphate dehydrogenase (G-6PDH) and epididymal sorbitol dehydrogenase (SDH). Rats exposed to LMR for one generation had not produced changes in their reproductive indices such as fertility index, gestation index, live pups/ dam and sex ratio. There was no change in the preweanling evaluation of pups such as survival and growth index on post-natal days (PND) 0, 4, 7,14 and 21. No significant pathomorphological changes were observed in liver, brain, kidney and gonads of PND 21 pups. Absences of any major adverse effects in the adult as well as weanling rats suggest the safe use of allethrin-based LMR.

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Section: Discussionsupporting

confidence: 62%

Ninety-Day Toxicity and One-Generation Reproduction Study in Rats Exposed to Allethrin-Based Liquid Mosquito Repellent

Srivastava

Srivastava²,

Raizada³

2006

J. Toxicol. Sci.

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“…The toxic metabolites are formed in the liver and cause perivenous damage. 35 The perivenous injury caused by ethanol is associated with perivenous hypoxia. 36,37 Ethanol Metabolism: Mechanism and Zonation.…”

Section: Primary Liver Disease With Perivenous Hypoxia and Damagementioning

confidence: 99%

Oxygen: Modulator of metabolic zonation and disease of the liver

2000

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“…Although rare, cholestatic jaundice is a well-recognized side effect of methyltestosterone [7,8], The absence of an increased AP level together with that of bilirubin, as seen in our case and in the previously reported transplanted patient [1], is characteristic of methyltestosterone-induced liver injury [8], This hyperbilirubinemia is attri buted to an interference of the drug with bile flow through bile canaliculi. As cyclosporine is eliminated mainly through biliary excretion, reduced bile flow may result in increased serum cyclosporine levels with subse quent nephrotoxicity.…”

mentioning

confidence: 67%