Effects of ozone therapy on pain, swelling, and trismus following third molar surgery

Ozone therapy in dentistry: clinical experiences

“…The coagulum inside the alveolus is also blown up with high concentration ozone to use its sterilizing effect (Figure 11). 7,8 …”

Analysis of electric field and emission spectrum in the glow discharge of therapeutic plasma electrode

“…A clinical evaluation of such method indicates positive results in disinfection [13][14][15] post-surgical soft tissue and bone healing and pain relief [16][17][18][19][20], treatment of various oral and dental diseases [21][22][23][24], reduction of temporomandibular disorder-related pain [25], and bisphosphonate-related osteonecrosis of the jaw [26]. In recent available literature found on the clinical application of plasma electrode coupled with high-frequency generator, all of the reported therapeutic effects are generally ascribed to bio-oxidative effects of ozone [14][15][16][17][18][19][20][21][22][23][24][25][26].…”

“…However, in the treatment modes when plasma electrode is applied in direct contact with the treated surface (especially in treatment of tissues underlying intact skin) or is immersed in liquids (e.g. saliva or blood), in which DBD and ozone generation are limited or even missing (Figure 1(d)), therapeutic effects, like improved bone healing and pain reduction, are still observed [17][18][19]25].…”

“…Furthermore, Kazancioglu et al [17] reported that degree of pain and the number of analgesic tablets taken was significantly lower after extra-oral application of the plasma electrode at the insertion point of the masseter muscle after the third molar extraction (Omega probe, 80% intensity for 10 min on postoperative days 0, 1, 3, 5 and 7) but were not able to explain how ozone contributed to the regulation and/or inhibition of the transmission of the pain signal to the central nervous system. Kazancioglu et al [18] also demonstrated that both plasma electrode (120 s, three times a week for two weeks) and laser treatments (808 nm; 0.1 W, 4 J/cm) had a positive effect on bone formation in rat calvarial defect.…”

The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

“…The effects of ozone on bone healing have been histologically examined in recent studies. [34][35][36] Kazancıoğlu et al demonstrated that both ozone and laser therapies had a positive effect on bone formation in rat calvarial defect compared with the control group; also, ozone therapy was more effective than low level laser treatment. 35 Another study by the same authors 36 suggested that ozone therapy was useful for the reduction of postoperative pain and increased quality of life after third molar surgery.…”