Effects of oxytocin used during delivery on development: A retrospective cohort study

González-Valenzuela, María-José; García-Fortea, Pedro; Delgado-Ríos, Myriam; Cazorla-Granados, Olga; Blasco-Alonso, Marta; González-Mesa, Ernesto

doi:10.1080/13803395.2014.926864

Cited by 7 publications

(6 citation statements)

References 56 publications

(56 reference statements)

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“…This investigation differs from that of Gregory et al (2013) in that we excluded multiple births (though they report a sensitivity analysis excluding non-singleton births which did not change the results), and included IOL and mode of delivery in the same variable, thus investigating possible interaction between the two. Also, as previously noted (Vintzileos and Ananth 2013) In contrast to ASD, previous studies have reported no association between IOL and ADHD or developmental delay (Gonzalez-Valenzuela et al 2014;Silva et al 2014).…”

Section: Discussionmentioning

confidence: 76%

Obstetrical Mode of Delivery and Childhood Behavior and Psychological Development in a British Cohort

Curran

Cryan

Kenny

et al. 2015

J Autism Dev Disord

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The association between mode of delivery [specifically birth by Cesarean section (CS)] and induction of labor (IOL) psychological development at age 7 was assessed [including autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) and behavioral difficulties]. The Millennium cohort study, a nationally representative UK cohort of children (including 13,141 children), was used. There was no association between planned CS and ASD [aOR 0.58; (95 % CI 0.19-1.79)] or ADHD [aOR 0.54; (95 % CI 0.18-1.64)] analyses. Induced vaginal delivery was significantly associated with behavioral difficulties in unadjusted [OR 1.26; (95 % CI 1.03-1.54)], but not adjusted analysis [OR 1.15; (95 % CI 0.82-1.60)]. There was no association between mode of delivery and ASD or ADHD in this cohort. Further research is needed to understand the relationship between mode of delivery and IOL and psychological development.

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Section: Discussionmentioning

confidence: 76%

Obstetrical Mode of Delivery and Childhood Behavior and Psychological Development in a British Cohort

Curran

Cryan

Kenny

et al. 2015

J Autism Dev Disord

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“…The earliest published study did not support an association between use of oxytocin and developmental delay (RR 1.46; 95% CI 0.79–2.71; Gonzalez-Valenzuela et al ., 2014). Risk estimates were significant for mothers under the age of 28 and over 35 years, in infants born after non-instrumental deliveries, and infants born without anesthesia.…”

Section: Resultsmentioning

confidence: 99%

Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

et al. 2018

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Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood. We assessed the quality of studies using the Newcastle–Ottawa Quality Assessment Scales. Independent risk estimates were pooled using random-effects meta-analyses when at least two independent datasets provided data on the same symptom or disorder. Otherwise, we provided narrative summaries. Two studies examined cognitive impairment, one examined problem behavior, three examined attention-deficit/hyperactivity disorder (ADHD) and seven focused on autism spectrum disorders (ASD). We provided narrative summaries of the studies on cognitive impairment. For ADHD, the pooled risk estimate was 1.17; 95% confidence interval (CI) 0.77–1.78, based on a pooled sample size of 5 47 278 offspring. For ASD, the pooled risk estimate was 1.10; 95% CI 1.04–1.17, based on 8 87 470 offspring. Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated.

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“…To evaluate the obstetric and neonatal variables, we analysed the clinical records of the mothers and their offspring during gestation and birth. The independent and control variables included were dichotomized according to previous studies (González‐Valenzuela, García‐Fortea, Delgado‐Ríos, Cazorla‐Granados, Blasco‐Alonso, & González‐Mesa, ; González‐Valenzuela, López‐Montiel, & González‐Mesa, ): maternal age at delivery above or below 35 years; fetal presentation—cephalic or non‐cephalic (podalic and breech); gestational age of the newborn above or below 37 weeks; newborn's weight more or less than 1,500 g; 1‐min Apgar above or below seven points.…”

Section: Methodsmentioning

confidence: 99%

Type of delivery and reading, writing, and arithmetic learning in twin births

González-Valenzuela

López‐Montiel

Cazorla-Granados³

et al. 2019

Developmental Psychobiology

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This study analyses, in children born in twin births, the relationship between reading, writing and arithmetic learning, on the one hand, and type of delivery, on the other, controlling for the effect of interaction and/or confusion of third variables (maternal age at delivery, gestational age, fetal position, birthweight, 1-min Apgar score). In the planned retrospective cohort design, the exposed cohort consisted of children born by caesarean section, and the non-exposed cohort was comprised of children born vaginally. One hundred and twenty-four children born of twin births were evaluated during their first year of primary school: K-BIT tests were used to measure intelligence; the Evalúa-1 battery was used to assess reading, writing, and arithmetic ability; and the children's clinical histories were analysed for obstetric and neonatal variables. After applying binary logistic regressions for each dependent variable, it was found that caesarean delivery in twin births appeared as a possible independent risk factor for specific learning disabilities (LDs) in reading, writing, and arithmetic.Based on these results, further research using larger samples and at more advanced ages is required in order to analyse the influence of obstetric and neonatal variables on the processes underlying specific LDs. K E Y W O R D Sarithmetic, learning disabilities, reading, twin births, type of delivery, writing | 485 GONZÁLEZ-VALENZUELA Et AL. from the need to deal 'simultaneously' with the delivery of two fetuses. Although there are international guidelines about how to deal with multiple deliveries, these are based on the recommendations of experts rather than on randomized studies (Lindstrom,

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Effects of oxytocin used during delivery on development: A retrospective cohort study

Abstract: Although oxytocin administration during delivery did not affect the overall risk of low Battelle Developmental Inventory scores in the study sample, some effects were seen according to maternal age and type of birth.

Cited by 7 publications

References 56 publications

Obstetrical Mode of Delivery and Childhood Behavior and Psychological Development in a British Cohort

Obstetrical Mode of Delivery and Childhood Behavior and Psychological Development in a British Cohort

Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

Type of delivery and reading, writing, and arithmetic learning in twin births

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