Effects of oxybenzone on zebrafish behavior and cognition

Moreira, Ana Luisa Pires; Luchiari, Ana Carolina

doi:10.1016/j.scitotenv.2021.152101

Cited by 25 publications

(11 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This outcome may suggest the presence of the hormesis phenomenon, wherein exposure to a low concentration is harmful, and elevated concentrations trigger various other organic responses (such as cortisol release and increased metabolic demands) that counteract the initial effect. Similar hormesis effects have been observed with other toxins and drugs, exemplified by oxybenzone [ 29 ]. These authors showed that adult zebrafish exposed to oxybenzone at 10µg/L presented increased locomotor activity, while higher concentrations did not cause hyperactivity, suggesting an interaction of the drug with other organic systems, as the endocrine system.…”

Section: Discussionsupporting

confidence: 75%

Embryotoxic Effects of Pesticides in Zebrafish (Danio rerio): Diflubenzuron, Pyriproxyfen, and Its Mixtures

Teixeira,

de Souza,

Macedo-Sampaio

et al. 2024

Toxics

Self Cite

View full text Add to dashboard Cite

Diflubenzuron (DFB) and pyriproxyfen (PPF) are larvicides used in crops to control insect plagues. However, these pesticides are known to impact non-target organisms like fish and mammals. Here, we aimed at assessing the embryotoxicity of purified DFB, PPF, and their mixtures in a non-target organism—zebrafish. Zebrafish embryos were exposed to different concentrations for 120 h: 0.025, 0.125, 0.25, 1.25, 2.5, and 10 mg/L of purified PPF and purified DFB, while we used 0.025 mg/L PPF + 10 mg/L DFB (Mix A), 0.125 mg/L PPF + 10 mg/L DFB (Mix B), and 0.25 mg/L PPF + 10 mg/L DFB (Mix C) for the mixtures of PPF + DFB. We observed mortality, teratogenicity, and cardiotoxicity. For the neurotoxicity tests and evaluation of reactive oxygen species (ROS) levels in the brain, embryos were exposed for 120 h to 0.379 and 0.754 mg/L of PPF and 0.025 and 0.125 mg/L of DFB. We established the LC50 for PPF as 3.79 mg/L, while the LC50 for DFB was not determinable. Survival and hatching were affected by PPF concentrations above 0.125 mg/L, DFB concentrations above 1.25 mg/L, and the lower pesticide mixtures. PPF exposure and mixtures induced different types of malformations, while a higher number of malformations were observed for the mixtures, suggesting a potentiating effect. Pesticides diminished avoidance responses and increased the levels of ROS across all concentrations, indicating neurotoxicity. Our findings underscore the detrimental impact of PPF and DFB exposure, spanning from biochemistry to morphology. There is a critical need to reconsider the global use of these pesticides and transition to more ecologically friendly forms of pest control, raising an alarm regarding repercussions on human and animal health and well-being.

show abstract

Section: Discussionsupporting

confidence: 75%

Embryotoxic Effects of Pesticides in Zebrafish (Danio rerio): Diflubenzuron, Pyriproxyfen, and Its Mixtures

Teixeira,

de Souza,

Macedo-Sampaio

et al. 2024

Toxics

Self Cite

View full text Add to dashboard Cite

show abstract

“…There have been several studies reporting the neurotoxic effects of BUVSs at the cellular and molecular level. Song et al [ 65 ] exposed larval zebrafish ( Danio rerio ) to 0.8, 1, 1.2, 1.6, or 2.4 µg/mL and adult zebrafish to 1, 10, 100, or 1000 µg/L benzophenone-1 (BP-1) and reported that BP-1 decreased the number of dopaminergic neurons in the midbrain and induced the loss of neurons in the central nervous system (midbrain and thalamus) in a concentration-dependent manner. Zebrafish exposed to 2.4 µg/mL also lost a significant number of neurons in their tails.…”

Section: Neurotoxicity Of Ultraviolet Stabilizers In Fishmentioning

confidence: 99%

“…Following exposure to 1.6 and 2.4 µg/mL, brain-derived neurotrophic factor ( bdnf ) and myelin basic protein a ( mbpa ) decreased and increased in expression, respectively. Additionally, pro-opiomelanocortin ( pomc ) expression was reduced in fish exposed to 0.8 and 1.0 µg/mL, and glial fibrillary acidic protein ( gfap ) expression was reduced in fish exposed to between 1.0 and 2.4 µg/mL [ 65 ]. Additional studies support the hypothesis that BUVSs induce oxidative stress and neuroinflammation in fish.…”

Section: Neurotoxicity Of Ultraviolet Stabilizers In Fishmentioning

confidence: 99%

Neurotoxicity of Benzotriazole Ultraviolet Stabilizers in Teleost Fishes: A Review

Li,

Ivantsova,

Liang

et al. 2024

Toxics

View full text Add to dashboard Cite

Plastic additives that maintain integrity have been extensively studied for potential toxicity to fish; however, chemicals that protect polymers from (artificial) UV degradation are less studied. Benzotriazole UV stabilizers (BUVSs) are the most widely used UV stabilizers in plastics and are often used in sunscreens, cosmetics, paint, and food packaging. BUVSs can negatively affect aquatic wildlife when released into the environment via plastic degradation. In this review, we summarize the distribution of BUVSs globally and discuss neurotoxicological endpoints measured in fish to understand how these plastic additives can affect the neurological health of teleost fishes. BUVSs have been detected in aquatic environments at concentrations ranging from 0.05 up to 99,200 ng/L. Studies show that BUVSs affect behavioral responses and acetylcholinesterase activity, indicators of neurotoxicity. Our computational analysis using transcriptome data suggests certain pathways associated with neurodegeneration are responsive to exposure to BUVSs, like “Complement Activation in Alzheimer’s Disease”. Based on our review, we identify some research needs for future investigations: (1) molecular studies in the central nervous system to define precise mechanisms of neurotoxicity; (2) a wider range of tests for assessing aberrant behaviors given that BUVSs can affect the activity of larval zebrafish; and (3) histopathology of the nervous system to accompany biochemical analyses. These data are expected to enhance understanding of the neurotoxicity potential of benzotriazoles and other plastic additives.

show abstract

“…Pokazalo se da je izloženost zebrica oksibenzonu negativno utjecala na njihovu percepciju okoline, povećalo se njihovo izlaganje opasnostima (smanjena mogućnost bijega od predatora), smanjio se odgovarajući agresivni odgovor na opasnost te se smanjila njihova sposobnost pamćenja. 25 U SAD-u je provedeno istraživanje u kojem se proučavao utjecaj oksibenzona prisutnih u kremama za sunčanje na smrtnost, sposobnost plivanja te sposobnost hranjenja ribe klaun (Amphiprion ocellaris). 26 Izlaganje testnog organizma kremi za sunčanje s koncentracijom oksibenzona od 100 mg l −1 dovelo je do 25,00 % smrtnosti vrste Amphiprion ocellaris nakon 97-satnog testnog razdoblja.…”

Section: Ispitivanje šTetnih Učinaka Organskog Uv Filtra Bezofenon-3 ...unclassified

SPF – super problematična formula? Aktivni sastojci krema za sunčanje u vodenom okolišu

Blažević¹,

Kos²,

Kovačević³

et al. 2023

Kemija U Industriji

View full text Add to dashboard Cite

show abstract

Effects of oxybenzone on zebrafish behavior and cognition

Cited by 25 publications

References 61 publications

Embryotoxic Effects of Pesticides in Zebrafish (Danio rerio): Diflubenzuron, Pyriproxyfen, and Its Mixtures

Embryotoxic Effects of Pesticides in Zebrafish (Danio rerio): Diflubenzuron, Pyriproxyfen, and Its Mixtures

Neurotoxicity of Benzotriazole Ultraviolet Stabilizers in Teleost Fishes: A Review

SPF – super problematična formula? Aktivni sastojci krema za sunčanje u vodenom okolišu

Contact Info

Product

Resources

About