Effects of oxotremorine on local glucose utilization in the rat cerebral cortex

Dam, Mauro; Wamsley, James K.; Rapoport, Si; London, E. D.

doi:10.1523/jneurosci.02-08-01072.1982

Cited by 41 publications

(10 citation statements)

References 10 publications

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“…The effects of scopolamine on LCGU in hippocampal and cortical structures (medial, auditory layer IV, frontal layers IV and V) agree well with the results of Dam et al (1982). Weinberger et al (1979) found a significant decrease in the auditory cortex, similarly noted in the present study in layers IV and V, whereas Dam et al (1982) showed a nonsignificant decreased.…”

Section: Discussionsupporting

confidence: 91%

Muscimol-scopolamine interactions in the rat brain: a study with 2- deoxy-D-[1-14C]glucose

Helén¹,

London²

1984

J. Neurosci.

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The 2-deoxy-D[1-14C]glucose method of Sokoloff was used to measure local cerebral glucose utilization (LCGU) in rats after injections of the GABA receptor agonist, muscimol (1.6 mg/kg and 4.0 mg/kg, i.v.); the muscarinic receptor antagonist, scopolamine (0.4 mg/kg and 2.0 mg/kg, i.v.); or combinations of both drugs. The aim was to identify brain regions where functional effects of GABAergic-cholinergic interactions could be seen. As noted previously, muscimol reduced LCGU in many brain regions. In contrast, scopolamine alone had no effect on LCGU in most brain regions; however, decreases were seen in the medial geniculate body, medial thalamic nucleus, and auditory and frontal cortical areas. Scopolamine increased LCGU in the cerebellar vermis and mesencephalic reticular formation. Although muscimol alone did not significantly affect LCGU in the external plexiform layer of the olfactory bulb or the anterior, periventricular, and parafascicular thalamic nuclei, rats treated with 0.4 mg/kg of scopolamine before 4.0 mg/kg of muscimol had LCGU decrements in those brain regions. Furthermore, the muscimol-induced decrease in LCGU in the medial cortex was enhanced by prior treatment with 0.4 mg/kg of scopolamine. In contrast, in certain brain regions where muscimol alone reduced LCGU (locus ceruleus; central gray matter; striatum; ventral, medial, reunients , and rhomboid thalamic nuclei; and the auditory cortex), scopolamine pretreatment antagonized these decrements. These findings suggest that endogenous cholinergic and GABAergic systems act antagonistically in some brain regions. However, in other brain regions, cholinergic transmission is required for full expression of GABAmimetic effects on LCGU.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 91%

Muscimol-scopolamine interactions in the rat brain: a study with 2- deoxy-D-[1-14C]glucose

Helén¹,

London²

1984

J. Neurosci.

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“…Consistent with this view is the fact that microiontophoretically administered LAC increased firing of cortical neurons and this effect was antagonized by atropine [34]. In addition, animal experiments showed that the administration of muscarinic agonists, such as oxotremorine and arecoline, elevate glucose utilization in the cortex of the rat brain, particularly in the parietal area [35,36].…”

Section: Discussionmentioning

confidence: 71%

Single-Photon Emission Computed Tomography Studies with <sup>99m</sup>Tc-Hexamethylpropyleneamine Oxime in Dementia: Effects of Acute Administration of L-Acetylcarnitine

Battistin

Pizzolato²,

M³

et al. 1989

Eur Neurol

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The acute effects of intravenously administered L-acetylcarnitine (LAC) were evaluated with single-photon emission computed tomography (SPECT) and 99mTc-hexamethylpropyleneamine oxime in 30 demented patients (21 with a clinical diagnosis of Alzheimer’s dementia and 9 with mixed-type dementia). Two SPECT scans were performed: in basal conditions, and 30 min after the administration of 500, 1,000, 1,500, or 2,000 mg LAC intravenously. Tracer activity ratios were determined in 10 pairs of cerebellar, cortical and subcortical regions. After administration of the lowest dose of LAC, no changes from the basal values were observed in any of the regions examined. The higher doses of the drug significantly elevated the tracer activity in cortical regions, particularly in the parietal lobe, which showed an impaired regional cerebral blood flow in the basal study. These effects of LAC and their relation with the cholinomimetic properties of the drug are discussed.

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“…In vitro, ace tylcholine can regulate neuronal activities through 1996 intracellular signaling processes such as those me diated by adenylate cyclase, phosphoinositide, or phospholipase C (Brown and Brown, 1984;Ash kenazi et al, 1987;Dauphin et al, 1994). It has been shown pharmacologically that acetylcholine effec tively excites cortical neurons (Dam et al, 1982;Sato et al, 1987). Thus, neuronal control by acetyl choline via these mechanisms presumably in creased the neuronal activity and energy demands of neurons, resulting in increased glucose consump tion, which was reflected as the increase in both CMR G lu and hexokinase activity, i. e., k3.…”

Section: Discussionmentioning

confidence: 99%

Cholinergic Projection from the Basal Forebrain and Cerebral Glucose Metabolism in Rats: A Dynamic PET Study

Ouchi

Fukuyama

Ogawa

et al. 1996

J Cereb Blood Flow Metab

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To investigate the influence of cholinergic projections from the basal forebrain on cerebral cortex metabolism, we evaluated the cerebral metabolic rate of glucose (CMRGlu) after selective inhibition of cholinergic neurons in the rat basal forebrain using the pyruvate dehydrogenase complex inhibitor 3-bromopyruvic acid (BPA), and compared the results with those obtained after lesioning the basal forebrain with ibotenic acid, as well as with those from a sham-operated control group. CMRGlu was measured using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-D-glucose (FDG). Three days after surgery, CMRGlu and k3 (phosphorylation of FDG) were reduced similarly in the frontal cortex on the BPA-injected side and in the ibotenic acid-treated group, whereas K1 (transport rate of FDG from the plasma to brain) showed no marked changes. At 3 weeks postoperatively, the CMRGlu and k3 of the frontal cortex in both groups recovered to levels similar to those of the sham-operated group. The main difference between the BPA and ibotenic acid groups was that CMRGlu showed mild reduction on the side contralateral to the operation in the former, while such reduction was confined to the ipsilateral hemisphere in the latter. The present results indicate that the cholinergic system in the basal forebrain regulates cerebral cortex glucose metabolism through direct excitation of cortical neurons.

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Effects of oxotremorine on local glucose utilization in the rat cerebral cortex

Cited by 41 publications

References 10 publications

Muscimol-scopolamine interactions in the rat brain: a study with 2- deoxy-D-[1-14C]glucose

Muscimol-scopolamine interactions in the rat brain: a study with 2- deoxy-D-[1-14C]glucose

Single-Photon Emission Computed Tomography Studies with <sup>99m</sup>Tc-Hexamethylpropyleneamine Oxime in Dementia: Effects of Acute Administration of L-Acetylcarnitine

Cholinergic Projection from the Basal Forebrain and Cerebral Glucose Metabolism in Rats: A Dynamic PET Study

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