Effects of oxidised dietary cod liver oil on the reproductive functions of Wistar rat

Zídková, J.; Sajdok, J.; Kontrová, K.; Kotrbová-Kozak, Anna; Hanis, T.; Zidek, Vaclav; Fučíková, Alena

doi:10.17221/3414-cjfs

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…The intake of Ω-3 PUFAs promotes the release of gonadotropin-releasing hormone (GnRH) primarily regulated by hypothalamic receptors of the reproductive system, which subsequently mediate the release of LH and FSH from pituitary glands [52]. A high intake of fish oil leads to a considerable rise in follicles development and ovulation and these actions depend on the hypothalamic-pituitary function [53]. Ω-3 PUFAs stimulated the follicogenesis process in ovaries, which may positively affect the efficiency of fertility [54].…”

Section: Discussionmentioning

confidence: 99%

Impact of different omega-3 fatty acid sources on lipid, hormonal, blood glucose, weight gain and histopathological damages profile in PCOS rat model

et al. 2020

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Background Omega-3 fatty acids (Ω-3 PUFAs) may help to improve health status in polycystic ovarian syndrome (PCOS) by reducing numerous metabolic disorders (insulin sensitivity, hyperinsulinemia, lipid profile, obesity and inflammation). To evaluate the current objective, 16 weeks (6 weeks of adjustment period followed by 10 weeks of collection period) research trial was planned to check the impact of different sources of Ω-3 PUFAs (synthetic Ω-3, flaxseed and fish oil) on nutrient digestibility, weight gain, productive (lipid profile, glucose and insulin), reproductive profile (progesterone, follicle stimulating hormone (FSH), estrogen, luteinizing hormone (LH) and prolactin) and histological study of ovarian tissues in Wistar female rats. Methods Forty-five rats of 130 ± 10 g weight were divided into 5 groups, each having 9 rats: NC (negative control without PCOS), PC (positive control with PCOS), SO (synthetic omega-3 containing ALA, EPA and DHA), FO (flaxseed oil) and F (fish oil) fed at 300 mg/kg/orally/daily of these sources were added in the basal diets while PC and NC received only the basal diet. Food and water were offered ad libitum. PCOS was induced in the rats fed of PC, SO, FO and F diets group by single intramuscular injection of estradiol-valerate (4 mg/rat/IM). Body weight and blood glucose was recorded weekly. At 16th week of trial, blood samples were collected for lipid and hormonal analysis. Ovarian tissues were removed for pathological evaluation. Digestibility was measured by total collection method. Results Cholesterol, triglycerides and low-density lipoproteins were reduced in SO, FO and F groups when compared with rats of PC group. However, increasing trend of high-density lipoprotein (HDL) was found in same groups. The highest HDL (36.83 ± 0.72 mg/dL) was observed in rats fed F diet. In case of a hormonal profile, testosterone, LH and insulin levels showed a significant reduction after treatments. Blood glucose results showed significantly reducing trend in all the rats fed with Ω-3 PUFAs sources than PC from 5 to 10th week of trial. However, similar trend was noticed in rat’s body weight at the end of 6th week. In ovarian morphology, different stages of follicles were observed in groups fed SO, FO and F diets. Nutrient digestibility in PCOS induced rats was remained non-significant. Conclusions The three sources of Ω-3 PUFAs had effective role in improving lipid and hormonal profile, reducing blood glucose, weight gain and histopathological damages in PCOS rats. However, fish oil source might be an innovative approach to cure PCOS via reducing the weight and metabolic anomalies due to EPA and DHA.

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Section: Discussionmentioning

confidence: 99%

Impact of different omega-3 fatty acid sources on lipid, hormonal, blood glucose, weight gain and histopathological damages profile in PCOS rat model

et al. 2020

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“…In this context, the development of liver tumors and the formation of 8-hydroxy-deoxyguanosine in the liver DNA of mice were observed by feeding them oxidized lard, soybean and sardine oils (Ichinose et al, 2004). On the other hand, high dosage of oxidized cod liver oil and lard, besides impaired fertility in female rats, caused morphologically abnormal spermatozoa in male rats (Zidkova et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The impact of saturated monoacylglycerols on the oxidative stability of Canola oil under various time/temperature conditions

Naderi

Farmani

Rashidi³

2018

Grasas y Aceites

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Due to the inconsistency of monoacylglycerols’ (MAGs) impacts and the lack of research concerning the weight of saturated monoacylglycerols on the oxidative stability of oils, the current study was designed. For this purpose, saturated MAGs at 0.5, 3.0 and 5.0% were added to canola oil and subsequently exposed to a Schaall oven test at 60 °C for 31 days (to assimilate moderate thermal conditions and a prolonged treatment time) and a Rancimat test at 110 °C (to assimilate extreme thermal conditions and shorter treatment time). To evaluate the quality and oxidative stability parameters of MAG-containing canola oil, free fatty acids (FFA), peroxide value (PV), and the oxidative stability index (OSI) were determined. The findings indicated that with the increase in MAG levels, the FFA increased from 0.05 up to 0.2%. The PV increased from 2 to 100 meq/L with the increase in MAG concentration. Also, it was shown that OSI increased from 12.20 to 13.10 h, which was proportional to MAG concentration.

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“…depend on hypothalamic-pituitary function (Zidkova et al 2004). Staples et al (1998) showed that PUFA affects ovarian dynamics leading to a few alterations in the numbers of follicles.…”

Section: Discussionmentioning

confidence: 99%

Stimulatory effects of fish oil and vitamin E on ovarian function of laying hen

Nateghi

Alizadeh

Ahangari

et al. 2018

Italian Journal of Animal Science

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In recent years, there has been an increase in the consumption of omega-6 fatty acids (FAs) over omega-3. Moreover, the antioxidant nature of oil supplemented diet in human and animal studies is not clear. In this work, the n-3 effects on hen ovarian cells, ovarian dynamics, serum FA profiles and expression level of apoptosis genes in the presence or absence of vitamin E were studied. Sixty-eight laying hens were randomly divided into four groups and the groups were fed the following diets: basal diet þ1.5% sunflower oil (control; C); basal diet þ1.5% sunflower oil þ1.1 U alpha-tocopherol/hen/day (E); basal diet þ1.5% fish oil þ1.1 U alphatocopherol/hen/day (n-3 þ E); and basal diet þ1.5% fish oil (n-3). In E, n-3 þ E and n-3, small yellow follicle numbers were higher than control (p < .05). Large yellow follicle numbers as well as total numbers of follicles of n-3 þ E and n-3 were higher (p < .05) than control and E. The rate of ovulation was significantly (p < .05) higher in n-3 (96%) compared to the control (89%). The proportion of intact primordial follicles in n-3 and n-3 þ E was significantly more than control and E (p < .01). The expression of Bak (Bcl2 antagonist/killer) was significantly (p < .05) higher in control than the other groups. There was significant reduction in expression of Cas9 in n-3 and E compared to the control and n-3 þ E (p < .05). While omega-3 and vitamin E can protect ovarian cells from apoptotic death, omega-3 source could have promoting roles on follicular development and ovulation rate, being independent of dietary vitamin E. HIGHLIGHTSDespite the perceived importance of supplementing antioxidant with fatty acids, our results indicated that alone low level of n-3 has a great influence on ovary performance. ARTICLE HISTORY

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Effects of oxidised dietary cod liver oil on the reproductive functions of Wistar rat

Cited by 6 publications

References 34 publications

Impact of different omega-3 fatty acid sources on lipid, hormonal, blood glucose, weight gain and histopathological damages profile in PCOS rat model

Impact of different omega-3 fatty acid sources on lipid, hormonal, blood glucose, weight gain and histopathological damages profile in PCOS rat model

The impact of saturated monoacylglycerols on the oxidative stability of Canola oil under various time/temperature conditions

Stimulatory effects of fish oil and vitamin E on ovarian function of laying hen

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