Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes

Soares, Aní­sio Francisco; Guichardant, Michel; Cozzone, D.; Bernoud-Hubac, Nathalie; Bouzaïdi-Tiali, N.; Lagarde, Michel; Géloën, Alain

doi:10.1016/j.freeradbiomed.2004.12.010

Cited by 176 publications

(139 citation statements)

References 45 publications

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“…28,29 Hypoadiponectinemia is also closely linked to endothelial dysfunction, which could be related to oxidative stress. 30,31 Adipose cells are highly sensitive to oxidative stress with subsequent decreased adiponectin secretion. 31 It has been suggested that in a prooxidative environmental milieu the original antioxidant properties of uric acid paradoxically become prooxidant, thus contributing to oxidative stress.…”

Section: -14mentioning

confidence: 99%

“…30,31 Adipose cells are highly sensitive to oxidative stress with subsequent decreased adiponectin secretion. 31 It has been suggested that in a prooxidative environmental milieu the original antioxidant properties of uric acid paradoxically become prooxidant, thus contributing to oxidative stress. 32 This may be a pathway linking uric acid to low adiponectin concentrations independent of obesity.…”

Section: -14mentioning

confidence: 99%

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Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

et al. 2006

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Background: In men, high adiponectin concentrations were related to a lower risk of myocardial infarction, whereas no association with cardiovascular events was found in women. Objective: To investigate sex differences in the associations of adiponectin with cardiovascular risk factors. Design: Cross-sectional population-based KORA Survey 2000 in Southern Germany using the same study methods for cardiovascular risk factors as the former WHO MONICA project. Participants: A total of 697 men and 657 women, aged 55-74 years. Glucose tolerance status was assessed by oral glucose tolerance tests. Results: Adiponectin (geometric mean, interquartile range; mg/ml) levels were significantly higher in women (11.1; 8.5-14.9) than in men (7.1; 5.2-9.6) (Po0.05). In univariate analyses, HDL-cholesterol and age were significantly positively correlated with adiponectin in both sexes. Negative correlations were observed with BMI, waist circumference, fasting and postchallenge glucose, insulin, HOMA-IR, HbA1c, triglycerides, uric acid and CRP (Po0.01). In sex-specific multivariate regression, age and HDL-cholesterol were independently positively, and fasting insulin and 2-h glucose were negatively related to adiponectin in both sexes. Uric acid was significantly inversely related to adiponectin in women only (sex interaction: P ¼ 0.02). Exploratory sex-specific factor analysis of adiponectin and the core components of the metabolic syndrome yielded four similar factors. Adiponectin loaded negatively on the 'lipids' factor in both sexes. Conclusion: The associations of adiponectin with cardiovascular risk factors showed a similar pattern in both sexes, except for uric acid. This small sex difference may not explain previous conflicting results on the association of adiponectin with cardiovascular events in men and women.

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Section: -14mentioning

confidence: 99%

Section: -14mentioning

confidence: 99%

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

et al. 2006

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“…We and others have found that the levels of 4-HNE are higher in the blood and/or muscle tissue of obese individuals than in lean subjects (19). Previous studies indicated that 4-HNE inhibited adiponectin gene expression and secretion in 3T3-L1 adipocytes; however, the mechanisms were not investigated (20). Strong evidence supports that oxidative stress plays a pathologic role in obesity-related disorders; however, the underlying mechanisms of the effects of 4-HNE on adiponectin gene expression and secretion, as well as its involvement in obesity-related decline, remain elusive.…”

Section: Discussionmentioning

confidence: 81%

“…As reported 4-HNE, the most abundant lipid peroxidation end product, differentially regulates adiponectin gene expression and secretion by activating PPARγ and accelerating ubiquitin-proteasome degradation (2). Although several animal experiments have suggested 4-HNE as an important regulator of glucose metabolism and insulin sensitivity, the clinical relevance of these findings in humans remains poorly characterized (18,20). The HNE-protein adduct ELISA is a method to detect HNE bound to proteins, which is considered as the most likely form of HNE in living systems (21).…”

Section: Discussionmentioning

confidence: 99%

Association of 4-hydroxynonenal with classical adipokines and insulin resistance in a Chinese non-diabetic obese population

Guo¹,

Zhang²,

Zhang³

et al. 2017

Nutr Hosp

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Background: The prevalence of obesity is increasing worldwide. Oxidative stress plays an etiological role in a variety of obesity-related metabolic disorders. 4-hydroxynonenal (4-HNE) is the most abundant and reactive aldehydic product derived from the peroxidation of n-6 polyunsaturated fatty acids with diverse biological effects that are not well detailed. Obesity is associated with decreased plasma adiponectin concentrations and increased production of lipid peroxidation products, including 4-HNE, in adipose tissue. There may be some association between the level of adipokines and 4-HNE. Material and methods:To analyze the associations between 4-HNE and classical adipokines, namely, adiponectin and leptin in a Chinese population, the plasma 4-HNE, adiponectin and leptin levels of 160 non-diabetic obese (NDO) patients and 160 healthy subjects were determined by ELISA, and their associations with adiposity, glucose, lipid profi les, insulin secretion and insulin sensitivity were studied. Results: Plasma 4-HNE levels were signifi cantly increased in patients with NDO compared with healthy controls (p < 0.01). 4-HNE was negatively correlated with adiponectin and positively correlated with leptin. The plasma levels of 4-HNE were signifi cantly correlated to several parameters involved in body mass index (BMI) and insulin resistance (IR). The 4-HNE levels were positively correlated with BMI and negatively correlated with insulin sensitivity. Conclusion: We conclude that 4-HNE is associated with the secretion of adiponectin and leptin and is correlated with IR in NDO humans. These fi ndings indicate a pro-infl ammatory role of 4-HNE in NDO patients, which supports the potential role of 4-HNE in the development of obesity-related disorders.

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“…Adipokines are bioactive peptides produced by adipose tissue and involved in the physiological regulation of fat storage, energy metabolism, food intake, insulin sensitivity, and immune function among others. Several trials have observed that oxidative stress caused dysregulated production of adipokines (Soares et al, 2005;Kamigaki et al, 2006), therefore, it could be very important in the future to analyze the effects of resveratrol on these adipokines in an attempt to restore the optimal concentrations of those which, in turn, could lead to an improvement in obesity and related disorders.…”

Section: Resveratrolmentioning

confidence: 99%

Compounds with Antioxidant Capacity as Potential Tools Against Several Oxidative Stress Related Disorders: Fact or Artifact?

Pérez-Matute¹,

Crujeiras²,

Fernández‐Galilea³

et al. 2012

Oxidative Stress and Diseases

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Oxidative Stress and Diseases 544 reactive species: reactive oxygen species (ROS, thus, oxygen-containing molecules that are highly reactive), reactive chlorine species (RCN) and reactive nitrogen species (RNS). All these reactants contain free radicals as well as nonradicals. Low concentrations of these reactive species are necessary for normal cell redox status, cell function and intracellular signalling (Droge, 2002;Valko et al., 2007;Perez-Matute et al., 2009). However, in some disease states, free radicals are produced in excess and can damage DNA, proteins, carbohydrates and lipid constituents and compromise cell function leading to the development of type 2 diabetes, atherosclerosis, obesity, arthritis etc. Thus, it is clear that excessive production of free radicals causes damage to biological material and is an essential event in the aetiopathogenesis of various diseases. However, the question that has risen in the past years is whether uncontrolled formation of ROS is a primary cause or a downstream consequence of the pathological processes. In other words, it is still not clear what comes first, the chicken or the egg. However, what is clear is that there must be a balance between these reactive species and the antioxidants, whose main function is to counteract the deleterious effects of these reactive species. In fact, antioxidant is defined as any substance that when present at low concentrations compared with those of an oxidizable substrate, significantly delays or prevents oxidation of that substrate (Halliwell & Gutteridge, 1999). These defences include both enzymatic (superoxide dismutases, glutathione peroxidase, catalase, thioredoxin) and non-enzimatic systems (vitamins such as vitamin C, E, A, minerals such as selenium, zinc, cooper, bilirrubine, uric acid, some aminoacids etc).Several studies have demonstrated an increased oxidative state (either caused by an increased ROS production or diminished levels of antioxidants) in serious pathologies such as obesity, cardiovascular diseases, metabolic syndrome, cancer etc. Thus, oxidative stress actually may be related with the mentioned processes. In this context, it is tempting to suggest that if oxidative damage significantly contributes to disease pathology, then, actions that decrease it (via decreasing ROS production or increasing endogenous levels of antioxidants) might be therapeutically beneficial. In fact, attenuation or complete suppression of oxidative stress as a way to improve several diseases has flourished as one of the main challenges of research in the last years. Thus, several approaches have been carried out in order to either decrease the high levels of ROS generated or boost the endogenous levels of antioxiants. Inhibition of ROS production through the development of inhibitors (natural or chemical) against the main sources of ROS generation offers an interesting approach. Thus, NADPH oxidase and mitochondria have been postulated as the main targets to reduce ROS production (reviewed by Pérez-Matute et al., 2009). Another str...

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Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes

Cited by 176 publications

References 45 publications

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

Association of 4-hydroxynonenal with classical adipokines and insulin resistance in a Chinese non-diabetic obese population

Compounds with Antioxidant Capacity as Potential Tools Against Several Oxidative Stress Related Disorders: Fact or Artifact?

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