Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness

Fu, Chi Ling; Ye, Yi Ling; Lee, Yueh L.; Chiang, Bor‐Luen

doi:10.1186/1465-9921-7-72

Cited by 52 publications

(41 citation statements)

References 61 publications

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“…Consistent with our findings in children with asthma, Ogawa and colleagues reported that the CC genotype of SNP rs1800469 was associated with increased airway responsiveness in 590 adults with COPD (33). If allele C of SNP rs1800469 is in fact correlated with reduced levels of TGF-b1 (see below), our findings and those of Ogawa and colleagues are consistent with those of murine models of allergic airway inflammation that suggest that antagonism of TGF-b1 results in increased airway responsiveness (34), and that intratracheal administration of TGF-b1 inhibits antigeninduced airway responsiveness (35). * All analyses were conducted under the assumption of a dominant genetic model.…”

Section: Discussionsupporting

confidence: 80%

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Sharma¹,

Raby²,

Hunninghake³

et al. 2009

Am J Respir Crit Care Med

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Rationale: Polymorphisms in the gene for transforming growth factor-b1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma. Objectives: To test for association between single nucleotide polymorphisms (SNPs) in TGFB1 and markers of asthma severity in childhood. Methods: We tested for the association between nine SNPs in TGFB1 and indicators of asthma severity (lung function, airway responsiveness, and disease exacerbations) in two cohorts: 416 Costa Rican parent-child trios and 465 families of non-Hispanic white children in the Childhood Asthma Management Program (CAMP). We also tested for the interaction between these polymorphisms and exposure to dust mite allergen on asthma severity. Measurements and Main Results: The A allele of promoter SNP rs2241712 was associated with increased airway responsiveness in Costa Rica (P 5 0.0006) and CAMP (P 5 0.005), and the C allele of an SNP in the promoter region (rs1800469) was associated with increased airway responsiveness in both cohorts (P < 0.01). Dust mite exposure modified the effect of the C allele of exonic SNP rs1800471 on airway responsiveness (P 5 0.03 for interactions in both cohorts). The T allele of a coding SNP (rs1982073) was associated with a reduced risk of asthma exacerbations in Costa Rica (P 5 0.009) and CAMP (P 5 0.005). Dust mite exposure also significantly modified the effect of the A allele of the promoter SNP rs2241712 on asthma exacerbations in both cohorts. Conclusions: SNPs in TGFB1 are associated with airway responsiveness and disease exacerbations in children with asthma. Moreover, dust mite exposure may modify the effect of TGFB1 SNPs on airway responsiveness and asthma exacerbations.

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Section: Discussionsupporting

confidence: 80%

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Sharma¹,

Raby²,

Hunninghake³

et al. 2009

Am J Respir Crit Care Med

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“…In the current study, Jian carp fed diets containing 7.0e11.9 g Ile kg À1 showed the lowest TNF-a mRNA levels than those fed other dietary Ile levels. TGF-b and IL-10, which are pleiotropic cytokine with significant anti-inflammatory properties, are key regulators in the maintenance of immunological homeostasis [61]. Interestingly, the present study showed that intestinal TGF-b2 genes were up-regulated with optimal Ile supplementation, whereas intestinal IL-10 mRNA levels in the intestine showed a downward to a point, and then increased.…”

mentioning

confidence: 51%

Effect of dietary isoleucine on the immunity, antioxidant status, tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian)

Zhao

Feng

Liu

et al. 2014

Fish & Shellfish Immunology

129

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“…Other studies have also shown that systemic production of IL-10 inhibits the development of airway hyperresponsiveness and allergic inflammation (33,34). IL-10 was reported to modulate Th2 responses by suppression of allergen-specific IgE production and concomitant induction of noninflammatory Ab isotypes, by reduction of proinflammatory cytokines released by mast cells, basophils, and eosinophils, and by indirect interference with Th2-associated phenomena such as mucus production (35,36).…”

Section: Discussionmentioning

confidence: 99%

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

Schnoeller

Rausch

Pillai

et al. 2008

The Journal of Immunology

226

196

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The coincidence between infections with parasitic worms and the reduced prevalence of allergic disease in humans and in animal models has prompted the search for helminth molecules with antiallergic and antiinflammatory potential. We report herein that filarial cystatin, a secreted protease inhibitor of filarial nematodes, suppresses Th2-related inflammation and the ensuing asthmatic disease in a murine model of OVA-induced allergic airway responsiveness. Treatment with recombinant filarial cystatin inhibited eosinophil recruitment, reduced levels of OVA-specific and total IgE, down-regulated IL-4 production, and suppressed allergic airway hyperreactivity when applied during or after sensitization and before challenge with the allergen. Depletion of macrophages by clodronate-containing liposomes prevented the curative effects and restored the levels of infiltrating cells, IgE, and allergic airway reactivity. Blocking of IL-10 by application of anti-IL-10 receptor Abs restored the reduced number of infiltrating cells and the levels of OVA-specific IgE. In contrast, depletion of regulatory T cells by anti-CD25 Abs had only limited effects. Cystatin also modulated macrophage-mediated inflammation in a murine model of dextran sulfate sodium-induced colitis, leading to reduction of inflammatory infiltrations and epithelial damage. Our data demonstrate that treatment with a single helminth protein can exert the antiallergic effects of helminth infections.

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Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness

Abstract: Our data demonstrated that anti-inflammatory cytokines, particularly IL-10, have the therapeutic potential for the alleviation of airway inflammation in murine model of asthma.

Cited by 52 publications

References 61 publications

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Effect of dietary isoleucine on the immunity, antioxidant status, tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian)

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

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