Effects of oral isotretinoin therapy on the nasal cavities

Taşlı, Hamdi; Yürekli, Aslan; Gökgöz, Mert Cemal; Karakoç, Ömer

doi:10.1016/j.bjorl.2018.10.004

Cited by 6 publications

(11 citation statements)

References 14 publications

(18 reference statements)

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“…It can also be preferred in ready-to-use products containing D-panthenol, Vaseline, glycerin, hypertonic solutions, and hyaluronic acid. 12 15.6 171 Brzezinski et al 13 47.2 3525 Gorpelioglu et al 10 40 40 Tasli et al 9 26.2 42 Akman et al 17 2 6 0 Rademaker 18 5.2 1745 This study 59.4 108…”

Section: Resultsmentioning

confidence: 81%

“…8 Isotretinoin is the most effective treatment agent used in the treatment of acne. 1 Tasli et al 9 have previously demonstrated that in the first month of isotretinoin treatment, MCT prolonged significantly (9.9 ± 2.06 minutes) according to the saccharin test. In this study, the MCT was 13.80 ± 2.29 minutes at the end of 6 months and was significantly longer ( P = .018).…”

Section: Discussionmentioning

confidence: 97%

“…2 The reason of this is that in literature, the nasal dryness is considered to be the underlying mechanism causing the decreased MCT (which is the objective finding of isotretinoin use) and epistaxis (which is the subjective finding of isotretinoin use). 2,9,10,13,14 In our study, epistaxis was evaluated with ESS questionnaire. 15 Five (4.9%) patients had a history of epistaxis in the last 6 months before the treatment, and this number increased to 60 (59.4%) when the treatment was completed (P ¼ .021).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

İşlek¹,

Yıldız²

2020

Ear Nose Throat J

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Objectives: The study aims to investigate the possible side effects of isotretinoin use on the nasal mucosa with objective methods in the treatment of acne vulgaris. Methods: Before the treatment, nasal mucociliary clearance time (MCT) was measured in all patients. Also all patients were asked to complete the questionnaires about the nasal dryness (visual analog scale [VAS]), nasal obstruction (Nasal Obstruction Symptom Evaluation [NOSE]), and presence of epistaxis (Epistaxis Severity Score [ESS]). Both MCT and questionnaires were reevaluated in patients who completed the treatment. Results: The results of 101 patients were evaluated. Before treatment, mean duration of nasal mucociliary clearance (NMC) was 9.55 ± 1.30 minutes, nasal dryness (VAS) value was 2.7 ± 0.7, NOSE score was 2.1 ± 1.1, and ESS score was 1.2 ± 0.7; after treatment, the duration of NMC was 13.80 ± 2.29 minutes, VAS value was 3.3 ± 1.1, NOSE score was 3.2 ± 1.3, and ESS score was 2.1 ± 1.2 ( P = .018, .150, .027, .011, respectively). Conclusion: The nasal mucosa is adversely affected in patients due to regular use of isotretinoin in the acne treatment, anamnesis should be checked in all nasal surgeries, and routine ear nose throat control should be recommended for these patients.

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Section: Resultsmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

İşlek¹,

Yıldız²

2020

Ear Nose Throat J

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“…North America and the European Union, implemented the pregnancy prevention program [250]. Tasli et.al, 2018 stated complaint of nasal obstruction [251].…”

Section: Spironolactonementioning

confidence: 99%

A Comprehensive Review of Acne Vulgaris

Mohiuddin¹

2019

CRDOA

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Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. It is characterized by blackheads or whiteheads, pimples, oily skin, and possible scarring. An intact stratum corneum and barrier, normal natural moisturizing factor and hyaluronic acid levels, normal Aquaporin-3 (AQP3) expression (localized at the basal lateral membranes of collecting duct cells in the kidney), and balanced sebum secretion are qualities of the skin that fall in the middle of the oily–dry spectrum. Patients rarely, if ever, complain about reduced sebum production, but elevated sebum production, yielding oily skin that can be a precursor to acne, is a common complaint. Several factors are known to influence sebum production. AV is mostly triggered by Propionibacterium acnes in adolescence, under the influence of normal circulating dehydroepiandrosterone (DHEA). It is a very common skin disorder which can present with inflammatory and noninflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back. Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles. Sebum, the oily secretion of the sebaceous glands containing wax esters, sterol esters, cholesterol, di- and triglycerides, and squalene, imparts an oily quality to the skin and is well known to play an important role in acne development. Acne can’t be prevented or cured, but it can be treated effectively. The pimples and bumps heal slowly, and when one begins to go away, others seem to crop up. Depending on its severity, acne can cause emotional distress and scar the skin. Acne may cause scarring of the skin, but generally causes no long-term health problems. In self-body image, some parts of the body including face play an important role. Existence of even a minor lesion in this part may be unpleasant for the patient and seems large. This image can cause mental disorders including depression and anxiety, low self-esteem, and decrease in social relationships. However, high levels of anxiety and depression in patients with facial acne are not related to oxidative stress, according to a study published online in the Journal of Cosmetic Dermatology

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“…North America and the European Union, implemented the pregnancy prevention program [250]. Tasli et.al, 2018 stated complaint of nasal obstruction [251]. Conventional and low dose isotretinoin regimens are associated with increased dermcidin (an antimicrobial peptide secreted by sweat glands that attacks any bacteria on our skin) expression [252].…”

Section: Isotretinoinmentioning

confidence: 99%

Acne Protection: Measures & Miseries

2019

ARC Journal of Pharmaceutical Sciences

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Effects of oral isotretinoin therapy on the nasal cavities

Cited by 6 publications

References 14 publications

Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

A Comprehensive Review of Acne Vulgaris

Acne Protection: Measures & Miseries

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