Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men

Tataka, Yusei; Haramura, Miki; Hamada, Y.; Ono, Miho; Toyoda, Sakiko; Yamada, Toshiyuki; Hiratsu, Ayano; Suzuki, Katsuhiko; Miyashita, Masashi

doi:10.1007/s00394-022-02806-1

Cited by 4 publications

(6 citation statements)

References 29 publications

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“…In 2022, targeted analyses were the most commonly applied approach for MS‐based research in SES, with 52 human participant studies published. These experiments were predominantly performed in plasma 6,16–35 or serum, 36–50 with other biosamples mediums utilized such as urine, 51–55 fecal matter, 56,57 breath gases, 58–63 red blood cells, 64 cerebrospinal fluid, 25 hair, 65 and whole blood via microsampling 66 . This excludes the use of IR and elemental MS to target specific isotope/elemental signatures, which are discussed individually within section 3.5.…”

Section: Analytical Approaches For Ms‐based Investigations In Ses In ...mentioning

confidence: 99%

“…In 2022, targeted analyses were the most commonly applied approach for MS-based research in SES, with 52 human participant studies published. These experiments were predominantly performed in plasma 6,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] or serum, [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] with other biosamples mediums utilized such as urine, [51][52][53][54][55] fecal matter, 56,57 breath gases, [58][59][60][61][62][63] red blood cells, …”

Section: Targeted Analysismentioning

confidence: 99%

“…In 2022, targeted analyses were the most commonly applied approach for MS‐based research in SES, with 52 human participant studies published. These experiments were predominantly performed in plasma 6 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 or serum, 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 with other biosamples mediums utilized such as urine, 51 , 52 , 53 , 54 , 55 fecal matter, 56 , 57 breath gases, 58 , 59 , 60 , 61 , …”

Section: Analytical Approaches For Ms‐based Investigations In Ses In ...mentioning

confidence: 99%

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Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

Ong

Green

Rowland

et al. 2023

Analytical Science Advances

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Research in sport and exercise science (SES) is reliant on robust analyses of biomarker measurements to assist with the interpretation of physiological outcomes. Mass spectrometry (MS) is an analytical approach capable of highly sensitive, specific, precise, and accurate analyses of a range of biomolecules, many of which are of interest in SES including, but not limited to, endogenous metabolites, exogenously administered compounds (e.g. supplements), mineral ions, and circulating/tissue proteins. This annual review provides a summary of the applications of MS across studies investigating aspects related to sport or exercise in manuscripts published, or currently in press, in 2022. In total, 93 publications are included and categorized according to their methodologies including targeted analyses, metabolomics, lipidomics, proteomics, and isotope ratio/elemental MS. The advantageous analytical opportunities afforded by MS technologies are discussed across a selection of relevant articles. In addition, considerations for the future of MS in SES, including the need to improve the reporting of assay characteristics and validation data, are discussed, alongside the recommendation for selected current methods to be superseded by MS‐based approaches where appropriate. The review identifies that a targeted, mostly quantitative, approach is the most commonly applied MS approach within SES, although there has also been a keen interest in the use of ‘omics’ to perform hypothesis‐generating research studies. Nonetheless, MS is not commonplace in SES at this time, but its use to expand, and possibly improve, the analytical options should be continually considered to exploit the benefits of analytical chemistry in exercise/sports‐based research. Overall, it is exciting to see the gradually increasing adoption of MS in SES and it is expected that the number, and quality, of MS‐based assays in SES will increase over time, with the potential for 2023 to further establish this technique within the field.

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Section: Analytical Approaches For Ms‐based Investigations In Ses In ...mentioning

confidence: 99%

Section: Targeted Analysismentioning

confidence: 99%

“…In 2022, targeted analyses were the most commonly applied approach for MS‐based research in SES, with 52 human participant studies published. These experiments were predominantly performed in plasma 6 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 or serum, 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 with other biosamples mediums utilized such as urine, 51 , 52 , 53 , 54 , 55 fecal matter, 56 , 57 breath gases, 58 , 59 , 60 , 61 , …”

Section: Analytical Approaches For Ms‐based Investigations In Ses In ...mentioning

confidence: 99%

See 1 more Smart Citation

Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

Ong

Green

Rowland

et al. 2023

Analytical Science Advances

View full text Add to dashboard Cite

show abstract

“…More recently, a double-blind, randomized, control-group human study investigated the influence of supplementation of cystine (0.23g), glutamine (1.00g) and maltodextrin (1.23g), or maltodextrin placebo (2.46g) per 5 days three times a day (10:00, 15:00 and before bed). Supplementation reduced intestinal permeability and inflammation markers [21]. A study of 30 healthy men randomized to glutamine supplementation (0.3g/kg + 25g of sugar) and placebo (25g of sugar) for 14 days.…”

Section: Rism000713 9(3)2023mentioning

confidence: 99%

"Single Ingredient Pre-Workout Supplements for Muscle Strength and Hypertrophy"

Fett

2023

RISM

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Currently, the supplement market has gained a large dimension, promising products that can increase performance and muscle hypertrophy. This review aimed to address which are the main single-component products suggested and how effective they are without intending to cover the entire subject. For that, we use our previous work and what is in the field. As main results, we observed that some supplements, such as caffeine and creatine, have a robust body of evidence regarding their effectiveness. Other products, such as beta alanine, BCAA, sodium bicarbonate, arginine, present several favorable results for their use, however, with some studies not proving this effectiveness. Thus, future well-controlled studies are suggested to clarify some controversies observed.

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“…In human studies, leucine-enriched essential AA supplementation before and after intense exercise (four × 12 min basketball game quarters and 20 min interval training) reduced IL-6 levels and muscle soreness in wheelchair basketball players [21]. Additionally, oral cystine and glutamine supplementations were reported to attenuate exercise-induced intestinal barrier dysfunction that might be associated with systemic inflammatory effects [22]. However, little has been reported on the effect of AA supplementation on IL-6 levels and subsequent iron regulation after endurance exercise.…”

Section: Introductionmentioning

confidence: 99%

Effect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise

Lin,

Hayashi,

Badenhorst

et al. 2023

Nutrients

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The purpose of this study was to determine the effects of pre-exercise amino acid (AA) supplementation on post-exercise iron regulation. Ten healthy males participated under two different sets of conditions in a randomized, double-blind, crossover design with a washout period of at least 21 days. Participants received either an AA supplement or placebo (PLA) for five consecutive days (4 g/dose, 3 doses/day). On the sixth day, participants ran on a treadmill for 60 min at 70% of maximal oxygen consumption (V˙O2max). Venous blood samples were collected before (baseline), immediately after, and 1 and 3 h after exercise. The serum hepcidin levels increased significantly 3 h post-exercise in both trials when compared to the baseline (p < 0.001), but the levels were not different between trials. The plasma interleukin-6 (IL-6) level significantly increased immediately after exercise compared to the baseline (p < 0.001) and was significantly higher in the AA trial than in the PLA trial (p = 0.014). Moreover, the exercise-induced increase in serum glycerol level was significantly higher in the AA trial (21.20 ± 3.98 mg/L) than in the PLA trial (17.28 ± 4.47 mg/L, p = 0.017). No significant differences were observed between the AA and PLA trials for serum iron, ferritin, and total ketone body levels (p > 0.05). In conclusion, five days of AA supplementation augmented exercise-induced increases in IL-6 and glycerol in healthy males. However, it did not affect post-exercise iron status or regulation.

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Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men

Cited by 4 publications

References 29 publications

Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

"Single Ingredient Pre-Workout Supplements for Muscle Strength and Hypertrophy"

Effect of Amino Acid Supplementation on Iron Regulation after Endurance Exercise

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