Effects of oral cetirizine, a selective H antagonist, on allergen- and exercise-induced bronchoconstriction in subjects with asthma

Gong, Henry; Tashkin, Donald P.; Dauphinee, Beth; Djahed, Benham; Wu, Tzu‐Chin

doi:10.1016/0091-6749(90)90104-c

Cited by 24 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histamine-1 receptor antagonists (55,56) and anticholinergic drugs (57) seem to be rather ineffective in this setting. A long-term treatment with inhaled corticosteroids attenuates the response to cold air (58-61), indicating that this response is associated with the degree of asthmatic inflammation in the lower airways.…”

Section: Cold Air-provoked Short-term Responsesmentioning

confidence: 99%

Cold air-provoked respiratory symptoms: the mechanisms and management

Koskela

2007

International Journal of Circumpolar Health

185

137

View full text Add to dashboard Cite

Objectives. To describe the mechanisms and management of cold air-provoked respiratory symptoms. Study design. A literature review. Methods. The review includes human epidemiological studies, human and animal experimental studies, as well as human studies about management of the cold air-provoked respiratory symptoms. Results. Cold air is unlikely to be a causal factor initiating respiratory diseases but a symptom trigger. In the present review, the airway responses beyond these symptoms were divided into three types. The short-term responses are those that develop within minutes in response to sudden cooling of the airways. Subjects with asthma or rhinitis are especially prone to these responses. The long-term responses are those that develop in response to repeated and longstanding cooling and drying of the airways, usually in endurance athletes. Finally, there are the physiological, reflex-mediated lower-airway responses to cooling of the skin or upper airways. Conclusions. The mechanisms beyond cold air-provoked respiratory symptoms vary considerably and mainly depend on the individual's susceptibility and the ventilation level during the cold exposure. An understanding of these mechanisms is essential for successful management of the symptoms. (Int J Circumpolar Health 2007; 66(2) [91][92][93][94][95][96][97][98][99][100]

show abstract

Section: Cold Air-provoked Short-term Responsesmentioning

confidence: 99%

Cold air-provoked respiratory symptoms: the mechanisms and management

Koskela

2007

International Journal of Circumpolar Health

185

137

View full text Add to dashboard Cite

show abstract

“…Investigations of the effect of H 1 blockers on the EAR have produced variable and inconclusive results. [1][2][3][4][5] Leukotriene modifiers have been shown to provide reasonable inhibition of the EAR and LAR but do not completely abolish the response. [6][7][8][9][10] The idea that a mechanism involving multiple mediators might require multiple interventions continues to attract interest in the role of combination therapies for the treatment of atopic asthma.…”

mentioning

confidence: 99%

Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen

Davis¹,

Todd²,

Cockcroft³

2005

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…However, recent studies highlighted that the extent of protection diminishes with their exclusive regular use after 6-8 weeks both for short-acting and long-acting agonists (reviewed in [4]). Histamine has been implicated in EIB but antihistamines have been shown to offer modest protection against EIB [5]. However, there is some evidence that combined mediator blockade with both leukotriene and histamine-receptor antagonists results in greater symptom control than LTRAs alone in patients with persistent asthma [6].…”

mentioning

confidence: 99%

The combination of single-dose montelukast and loratadine on exercise-induced bronchospasm in children

Peroni¹,

Piacentini²,

Pietrobelli³

et al. 2002

European Respiratory Journal

View full text Add to dashboard Cite

The aim of the study was to evaluate the protective effect of single-dose, combination treatment comprising montelukast (5 mg) and loratadine (10 mg), on exercise-induced bronchoconstriction in asthmatic children. The combination was compared to placebo, loratadine and montelukast alone.Nineteen children were enrolled in a double-blind randomised, single-dose, crossover study. For each treatment patients undertook two treadmill exercise tests, 2 and 12 h respectively after single-dose administration.No significant differences were seen in the maximum fall in forced expiratory volume in one second (FEV1) 2 h after treatment and placebo. Whereas significant differences in maximum fall in FEV1 were observed between treatment groups 12 h after administration. Loratadine alone did not show any significant protection or any additional effect in comparison with montelukast alone. Single doses of montelukast and montelukast plus loratadine were significantly more effective than loratadine at 12 h.The present study, performed using single-dose treatments, demonstrated that maximal protective effect by montelukast was obtained 12 h after dosing and that montelukast plus loratadine did not result in significant additive bronchoprotective effects on exercise-induced bronchoconstriction.

show abstract

Effects of oral cetirizine, a selective H antagonist, on allergen- and exercise-induced bronchoconstriction in subjects with asthma

Cited by 24 publications

References 35 publications

Cold air-provoked respiratory symptoms: the mechanisms and management

Cold air-provoked respiratory symptoms: the mechanisms and management

Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen

The combination of single-dose montelukast and loratadine on exercise-induced bronchospasm in children

Contact Info

Product

Resources

About