Effects of oral administration of Ocimum basilicum on goblet cell hyperplasia and upstream cytokine gene expression in allergic asthma

Nasaba, E. Mehrabi; Athari, Seyyede Masoume; Motlagh, Behrooz; Athari, Seyyed Shamsadin

doi:10.1016/j.reval.2019.02.226

Cited by 16 publications

(17 citation statements)

References 31 publications

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“…In another study, it has been reported that oral administration of O. basilicum seed extract (on days 25, 27, and 29 from 30 days of sensitization period) inhibits the expression of Th2 upstream cytokines such as IL-8, IL-9, IL-11, IL-25, IL-33, and eotaxin and hyperplasia in goblet cell in an animal model of OVA-induced allergic asthma. These findings also revealed that therapeutic effects of the plant in asthma were induced by the inhibition of the Th2 expression and goblet cell hyperplasia ( Nasaba et al, 2020 ).…”

Section: Resultsmentioning

confidence: 88%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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Ocimum basilicum L. (O. basilicum) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of O. basilicum and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including “Ocimum basilicum,” “basilicums,” “linalool,” “respiratory disease,” “asthma,” “obstructive pulmonary disease,” “bronchodilatory,” “bronchitis,” “lung cancer,” and “pulmonary fibrosis,” and other related keywords.The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of O. basilicum and its constituent, linalool, on respiratory disorders.

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Section: Resultsmentioning

confidence: 88%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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“…Lung tissues of the mice were taken and fixed with formalin solution, and after histological sections preparation, were stained with H&E and PAS. The Histopathological slides were evaluated under the light microscopy for Peri-bronchiolar and perivascular eosinophil inflammation, mucus hypersecretion and hyperplasia of goblet cell, using a point scoring system [as described before ( Masoume Athari et al, 2018 , Mehrabi Nasaba et al, 2020 )].…”

Section: Methodsmentioning

confidence: 99%

“…Asthma is a complicated bronchial disease, which characterized by AHR, eosiniphilic inflammation, mucus hyper-production and airway remodeling. The morbidity and mortality rates of asthma have increased worldwide, and understanding and identification of the molecular mechanisms underlying immune-inflammatory progression of the asthma is necessary to develop new anti-asthma drugs ( Athari et al, 2017 , Masoume Athari et al, 2018 , Mehrabi Nasaba et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma

Huang¹,

Nasab

Athari

2021

Saudi Journal of Biological Sciences

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“…Mice sensitization and challenging is shown in Figure 1 as described previously [ 1 , 14 ]. Briefly, mice were sensitized with intraperitoneal (IP) injections of OVA solution with alum on days 1 and 14, and challenged with inhalation administration (IT) of OVA solution by nebulizer for 30 minutes on days 24, 26, 28, 30, 46, 48, and 50.…”

Section: Methodsmentioning

confidence: 99%

“…In asthmatic patients, bronchial inflammation causes airway narrowing, and goblet cell hyperplasia leads to mucus hypersecretion that blocks the airways. At the time of asthma attack, airway hyper-responsiveness (AHR) causes airflow obstruction, difficulty breathing, and may lead to death [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of herbal traditional medicine extract on molecular regulation in allergic asthma

Sun

Nasab

Athari

et al. 2021

ALS

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Asthma is an important global health problem, and the main cause of asthma is allergic reaction and immune system dysregulation. Airway inflammation causes bronchial narrowing, and goblet cell hyperplasia leads to mucus hypersecretion that leads to airflow obstruction and difficulty breathing. The Th2 cytokines can induce allergic asthma. Camellia, Adhatoda, and Glycyrrhiza are the traditional medicines that are used in some countries. In the current study, we evaluated three herbal extracts on airway inflammatory responses in asthmatic mice. The asthma model was induced in mice that were divided into 6 groups: Phosphate-buffered saline (PBS) group, ovalbumin (OVA) group, OVA-budesonide group, OVA-Glycyrrhiza group, OVA-Camellia group, and OVA-Adhatoda group. Measurements of IL-4, IL-5, IL-13, glutamate oxaloacetate transaminase (GOT), glutamic pyruvic transaminase (GPT), IgE, histamine, percentages of eosinophils in bronchoalveolar lavage fluid (BALf), gene expression of COX-2, CCL24, CCL11, eotaxin, and histopathological study of lung were done. Adhatoda significantly attenuated the IL-4, IgE, and histamine levels. Glycyrrhiza attenuated the levels of IL-5, IL-13, GTP, GOT (on day 51), mRNA expression of eotaxin, CCL24, CCL11, and COX-2, eosinophil infiltration, mucus secretion, and goblet cell hyperplasia. Camellia decreased IL-13, GTP, COX-2 mRNA expression, mucus secretion, and goblet cell hyperplasia on day 31 and 51. We evaluated effect of three plants on allergic bio-factors. Glycyrrhiza as main anti-inflammatory treatment, Adhatoda as anti-allergic, and Camellia as anti-mucus releasing treatment can be used in attacks of allergic asthma.

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Effects of oral administration of Ocimum basilicum on goblet cell hyperplasia and upstream cytokine gene expression in allergic asthma

Cited by 16 publications

References 31 publications

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma

Anti-inflammatory effect of herbal traditional medicine extract on molecular regulation in allergic asthma

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