Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure

Possible Benefit of Dietary Carnosine towards Depressive Disorders

“…In humans, carnosine supplementation has been found to enhance cognition and/or well-being in at least five studies [1,[44][45][46][47]. Dietary supplementation with carnosine provoked beneficial effects on behaviour in autistic children [44], and improved cognitive function in patients suffering from Gulf War Illness [45], schizophrenia [46], and chronic heart failure [1]; the latter group also reported a significantly improvement in their quality of life [1]. A recent study has shown that carnosine plus anserine supplementation improved cognitive function and physical capacity in elderly humans [47].…”

“…It has however been shown that raised levels of kidney carnosinase does increase the probability of diabetic kidney disease in type-2 diabetics [34], which is probably due to increased destruction of the dipeptide. Nevertheless the fact that beneficial effects of carnosine supplementation have been detected in humans [1,[44][45][46][47] suggests that carnosinase activity is not necessarily an impediment to the dipeptide's efficacy in all cases.…”

“…Dietary supplementation with carnosine has been shown to suppress stress in animals, and improve behaviour, cognition and well-being in human subjects. It is therefore proposed that the therapeutic potential of carnosine dietary supplementation towards stress-related and depressive disorders should be examined.Key words: carnosine, telomeres, human, diet, supplementation, depression, cognition, stress, cortisol, aging A recent paper [1] has shown that supplementation of human diets with carnosine (β-alanyl-L-histidine), a naturally-occurring neurobiological peptide, can provoke beneficial effects on exercise performance and quality of life. Another recent paper [2] has shown that major depressive disorder (MDD) is associated with reduced telomere length, increased susceptibility towards agerelated dysfunction and raised cortisol levels in response to stress, while two other recent papers have described an association between decreased leukocyte telomere length and stress-associated disorders [3,4].…”

“…A recent paper [1] has shown that supplementation of human diets with carnosine (β-alanyl-L-histidine), a naturally-occurring neurobiological peptide, can provoke beneficial effects on exercise performance and quality of life. Another recent paper [2] has shown that major depressive disorder (MDD) is associated with reduced telomere length, increased susceptibility towards agerelated dysfunction and raised cortisol levels in response to stress, while two other recent papers have described an association between decreased leukocyte telomere length and stress-associated disorders [3,4].…”

Carnosine and the processes of ageing

“…Supplementation with carnosine has been shown to have anti-inflammatory, antioxidant, antiglycation and chelating roles, and may act as a buffering agent in skeletal muscle and improve calcium handling [9][10][11][12]. Although circulating carnosine levels are affected by the presence of plasma carnosinase in humans [7], long-term supplementation of carnosine results in improved health and/or behavioural outcomes (27)(28)(29)(30)(31)(32). Therefore, it could be speculated that chronic supplementation maintains a more constant plasma level of carnosine mainly due to saturation of carnosinase.…”