Effects of OP-1206 α-CD on walking dysfunction in the rat neuropathic intermittent claudication model: comparison with nifedipine, ticlopidine and cilostazol

Nakai, Katsuhiko; Takenobu, Yoshifumi; Takimizu, Hideyuki; Akimaru, Shinji; Maegawa, Hitoshi; Ito, Hidenori; Maršala, Martin; Katsube, Nobuo

doi:10.1016/s1098-8823(03)00044-3

Cited by 11 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Another work used the maximum distance reached by a rat in a treadmill to study the effect of a prostaglandin E 1 analogue in a model of neurologic claudication. 18 In the present study, we used TNC and TDC as parameters of gait analysis. Left hindlimb TNC and TDC values were lower in ischemic groups in comparison with nonischemic ones (P Ͻ .01).…”

Section: Discussionmentioning

confidence: 99%

Effect of cilostazol and pentoxifylline on gait biomechanics in rats with ischemic left hindlimb

Bredarioli

Dalio

Joviliano

et al. 2012

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of cilostazol and pentoxifylline on gait biomechanics in rats with ischemic left hindlimb

Bredarioli

Dalio

Joviliano

et al. 2012

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

“…In the clinical setting, oral therapy with 15 to 30 μg per day OP1206 a-CD is used for an adult patient. In rat studies [ 15 , 16 ], oral administration of 30–300 μg/kg OP-1206α-CD has been used; however, these concentrations are higher than those used in the clinical setting. In a rat model, the blood concentration of OP1206α-CD is approximately 2 to 2.5% of the total amount of drug administered.…”

Section: Methodsmentioning

confidence: 99%

Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equina

Shirasaka

Takayama

Sekiguchi

et al. 2008

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Reduction of blood flow is important in the induction of neurogenic intermittent claudication (NIC) in lumbar spinal canal stenosis. PGE 1 improves the mean walking distance in patients with NIC type cauda equina compression. PGE 1 derivate might be effective in dilating blood vessels and improving blood flow in nerve roots with chronically compressed cauda equina. The aim of this study was to assess whether PGE 1 derivate has vasodilatory effects on both arteries and veins in a canine model of chronic cauda equina compression.

show abstract

Section: Introductionmentioning

confidence: 99%

“…3,5,6 Furthermore, augmentation of SCBF is associated with improved recovery of motor function in rat models of spinal cord compression. 7,8 Less is known about spinal cord responses to milder compression.With regard to the therapeutic potential of physical therapies, it is understood that various forms of somatic stimulation increase SCBF in animal models. Recent studies in urethane-anesthetized adult male rats confirm that innocuous somatic stimulation (cutaneous brushing) results in a segmentally organized reflex augmentation of regional SCBF in the intact spinal cord.…”

mentioning

confidence: 99%

TENS augments blood flow in somatotopically linked spinal cord segments and mitigates compressive ischemia

2014

View full text Add to dashboard Cite

Study Design: This was an acute basic physiological study in anesthetized adult male rats. Objectives: The purpose of this study was to determine, in an animal model, whether innocuous somatic stimulation, in the form of transcutaneous electrical nerve stimulation (TENS), could produce a sustained augmentation of spinal cord blood flow, and whether this effect was robust in the face of relatively mild, non-destructive compression of the spinal cord. INTRODUCTIONThe functional integrity of the spinal cord and spinal nerve roots is, of course, dependent upon adequate perfusion and the availability of oxygen. As one might expect, laboratory investigations of spinal cord/ nerve root function often model the most destructive lesions in which normal anatomical and physiological relationships have been disrupted. 1,2 In rat models of traumatic spinal cord injury, it has been demonstrated that both the extent and nature of neuronal damage are linked to the degree and duration of ischemia. 3,4 Compressive injury has been shown to cause an immediate and sustained decrease in local spinal cord blood flow (SCBF) in rat models. 3,5,6 Furthermore, augmentation of SCBF is associated with improved recovery of motor function in rat models of spinal cord compression. 7,8 Less is known about spinal cord responses to milder compression.With regard to the therapeutic potential of physical therapies, it is understood that various forms of somatic stimulation increase SCBF in animal models. Recent studies in urethane-anesthetized adult male rats confirm that innocuous somatic stimulation (cutaneous brushing) results in a segmentally organized reflex augmentation of regional SCBF in the intact spinal cord. 9 Furthermore, these studies suggest that, whereas neuronal activation is probably the most important mechanism underlying increased SCBF, alpha-adrenergic receptors also participate in this process. 10,11 The studies cited 9-11 employed stimulation periods of 30-60 s, and therefore it is unclear whether animals might quickly habituate to stimulation or whether the increases in SCBF could be maintained for periods likely to have

show abstract

Effects of OP-1206 α-CD on walking dysfunction in the rat neuropathic intermittent claudication model: comparison with nifedipine, ticlopidine and cilostazol

Cited by 11 publications

References 31 publications

Effect of cilostazol and pentoxifylline on gait biomechanics in rats with ischemic left hindlimb

Effect of cilostazol and pentoxifylline on gait biomechanics in rats with ischemic left hindlimb

Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equina

TENS augments blood flow in somatotopically linked spinal cord segments and mitigates compressive ischemia

Contact Info

Product

Resources

About