Effects of omega‐3 fatty acids and/or antioxidants on endothelial cell markers

Seljeflot, Ingebjørg; Arnesen, Harald; Ir, Brude; Ms, Nenseter; Ca, Drevon; Hjermann, Ingvar

doi:10.1046/j.1365-2362.1998.00336.x

Cited by 90 publications

(59 citation statements)

References 52 publications

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“…We are not aware of previous studies on soluble inflammatory factors that have been performed in a population readily comparable with ours. However, similar results, that is, an increase in sE-sel and sVCAM-1 after supplementation with n-3 FA, were recently described by Seljeflot et al 26 in a population of healthy individuals at high risk for atherosclerotic disease states. De Caterina et al 13 found in their study on cultured human endothelial cells that exposure to DHA led to reduced expression of cytokine-induced adhesion molecules.…”

Section: Table 2 Serum Phospholipid Fatty Acids (Mg/l) and Serum Lipsupporting

confidence: 84%

The Effect of Supplementation With Omega-3 Fatty Acids on Soluble Markers of Endothelial Function in Patients With Coronary Heart Disease

Johansen

Seljeflot

Høstmark

et al. 1999

ATVB

156

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Abstract-During progression of atherosclerosis the overlying endothelial cells alter their expression of some surface molecules. Circulating levels of such molecules may be quantified. We investigated the effect of omega-3 fatty acids (n-3 FA) on the levels of tissue plasminogen activator antigen, von Willebrand factor, and the soluble forms of thrombomodulin, P-selectin, E-selectin, and vascular cell adhesion molecule-1 in 54 patients with coronary heart disease. Twenty-three of the patients had taken 5.1 g/d n-3 FA for 6 months (group I) and 31 were given corn oil as placebo (group II). For another 4 weeks ("the study period") they all got 5.1 g/d of n-3 FA. Compliance was confirmed by demonstration of changes in relevant fatty acids in serum phospholipids. At baseline, significant differences between the groups were found with lower median values of von Willebrand factor (128% versus 147%) and soluble thrombomodulin (24.9 versus 32.5 ng/mL) and higher median values of soluble E-selectin (41.4 versus 35.5 ng/mL) and soluble vascular cell adhesion molecule-1 (573 versus 473 ng/mL) in group I. During the study period differences in changes between the groups were found; tissue plasminogen activator antigen and soluble thrombomodulin decreased (P for difference between the groups 0.001 and 0.015, respectively), whereas soluble E-selectin and soluble vascular cell adhesion molecule-1 increased (P for difference between the groups Ͻ0.01 for both) in group II relative to group I. Our results indicate that n-3 FA supplementation decreases hemostatic markers of atherosclerosis, whereas markers of inflammation may be increased. The latter may be the result of lipid peroxidation as a simultaneous decrease of vitamin E and increase in thiobarbituric acid-reactive substances were observed. (Arterioscler Thromb Vasc Biol.

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Section: Table 2 Serum Phospholipid Fatty Acids (Mg/l) and Serum Lipsupporting

confidence: 84%

The Effect of Supplementation With Omega-3 Fatty Acids on Soluble Markers of Endothelial Function in Patients With Coronary Heart Disease

Johansen

Seljeflot

Høstmark

et al. 1999

ATVB

156

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“…Myristic acid (14:0) and palmitic acid (16:0) concentrations have been shown to have a positive association with coronary heart disease risk while polyunsaturated omega-3 fatty acids, especially docosahexaenoic acid (DHA, 22:6n-3), have an inverse association (Simon et al, 1995). Our ®ndings are compatible with the latter study, in that myristic and palmitic acids were signi®cantly associated with increased serum triglyceride, whereas polyunsaturated omega-3 eicosapentaenoic acid (EPA, 20:5n-3) was associated with increased HDL-C. Supplementation of the diet with omega-3 fatty acids for 6 months has been shown to decrease endothelial cell markers thrombomodulin (sTM) and von Willebrand factor (vMF), and increase the soluble forms of the cell adhesion molecules E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in hyperlipidaemic middle-aged male smokers (Selje¯ot et al, 1998). A similar ®nding was observed in patients with coronary heart disease after 4 weeks' treatment (Johansen et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Serum fatty acid, lipid profile and dietary intake of Hong Kong Chinese omnivores and vegetarians

et al. 2000

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Objective: To examine the serum fatty acid and lipid pro®les and dietary intake of Hong Kong Chinese omnivores and vegetarians with respect to cardiovascular health. Design: Random population survey strati®ed by age and sex. Subjects: One-hundred and ninety-four omnivore subjects (81 men, 113 women) age 25 ± 70 y, and 60 ovo-lactovegetarian adults (15 men, 45 women) age 30 ± 55 y. Measurements: Nutrient quantitation was by a food frequency method. Serum fatty acids were analysed by gas chromatography, and serum lipid by standard laboratory methods.

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“…In vitro studies suggest that n-3 fatty acids decrease the expression of adhesion molecules on endothelium and decrease leukocyte-endothelium interactions (13). In addition, in coronary artery strips, fish oil augments endothelium-dependent relaxation (14).…”

Section: Fatty Acidsmentioning

confidence: 99%

Diet and Endothelial Function

Cuevas

Germaín

2004

Biol. Res.

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Endothelial dysfunction is one of the earliest events in atherogenesis. A consequence of endothelial damage is a lower availability of nitric oxide (NO), the most potent endogenous vasodilator. NO inhibits platelet aggregation, smooth muscle cell proliferation and adhesion of monocytes to endothelial cells. Endothelial dysfunction is present in patients with cardiovascular disease and/or coronary risk factors, such as hypertension, dyslipidemia, diabetes, smoking or hyperhomocysteinemia. At present, soluble markers and high resolution ultrasound of the brachial artery, have provided simple tools for the study of endothelial function and the effects of several interventions. It has been demonstrated that dietary factors may induce significant changes on vascular reactivity. Nutrients, such as fish oil, antioxidants, L-arginine, folic acid and soy protein have shown an improvement in endothelial function that can mediate, at least partially, the cardioprotective effects of these substances. Attention has been focused on dietary patterns in populations with lower prevalence of cardiovascular disease. There is some evidence suggesting that Mediterranean diet characterized by high consumption of vegetables, fish, olive oil and moderate wine consumption may have a positive effect on endothelial function. These results give us evidence on the significant role of diet on endothelial function and its impact on the pathogenesis of atherosclerosis.

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Effects of omega‐3 fatty acids and/or antioxidants on endothelial cell markers

Cited by 90 publications

References 52 publications

The Effect of Supplementation With Omega-3 Fatty Acids on Soluble Markers of Endothelial Function in Patients With Coronary Heart Disease

The Effect of Supplementation With Omega-3 Fatty Acids on Soluble Markers of Endothelial Function in Patients With Coronary Heart Disease

Serum fatty acid, lipid profile and dietary intake of Hong Kong Chinese omnivores and vegetarians

Diet and Endothelial Function

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