Effects of oestradiol and some of its esters on gonadotrophin release and ovarian follicular dynamics in CIDR-treated beef cattle

Martı́nez, M.F.; Kastelic, John P.; Bó, G. A.; Caccia, M.; Mapletoft, R.J.

doi:10.1016/j.anireprosci.2004.06.005

Cited by 91 publications

(52 citation statements)

References 37 publications

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“…When cows were treated with estradiol benzoate to induce wave emergence and a progesterone insert for 8 days, without an ovulation inducer, ovulation occurred ~96 hours after P 4 removal (Martinez et al, 2005), which is similar to that observed in the CTL group in the present work (Table 1). Souza et al (2009) evaluated the effect of GnRH and ECP as ovulation inducers in lactating dairy cows.…”

Section: Resultssupporting

confidence: 76%

“…However, based on the results of a previous study (Martinez et al, 2005) and on the foundational nature of the current work, we were not encouraged to risk using TAI in a large number of cows without treating them with an ovulation inducer. Considering that 55 to 65% of the cows are still not pregnant after the first postpartum AI (Bisinotto et al, 2010), the substitution of EB by PGF as the ovulation inducer in a TAI protocol provided satisfactory fertility in dairy cows (~40%).…”

Section: Resultsmentioning

confidence: 99%

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Prostaglandin F2α or estradiol benzoate to induce ovulation in timed artificially inseminated dairy cows

Pfeifer

Siqueira

Arashiro

et al. 2016

Pesq. agropec. bras.

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-The objective of this work was to compare two types of ovulation inducers -estradiol benzoate (EB group) or prostaglandin F2α (PG group) -, in postpartum dairy cows subjected to timed artificial insemination (TAI). Lactating Holstein-Gir crossbred cows (n=118) with 60 to 120 days of milk production were used in this study. All cows were treated with an intravaginal progesterone-releasing device (CIDR) plus 2 mg of estradiol benzoate (EB) on day 0. The CIDR inserts were removed on day 9, and all cows received 500 µg sodium cloprostenol. Twenty-four hours after CIDR removal, cows were randomly assigned into two treatment groups and were given either 1 mg of EB i.m. (EB group) or 500 µg sodium cloprostenol i.m. (PG group). TAI were performed at 52 to 54 hours, in both EB and PG groups, after CIDR removal. No differences were observed in the ovulation (85.2% vs 72.7%) and pregnancy rates (40.7% vs 38.2%) between the EB and PG groups, respectively. Fertility is similar in the TAI protocols that use prostaglandin F2α or EB to induce ovulation in lactating dairy cows.Index terms: artificial insemination, cattle, estrus, synchronization, withdrawal period. Prostaglandina F2α ou benzoato de estradiol para induzir a ovulação em vacas leiteiras inseminadas em tempo fixoResumo -O objetivo deste trabalho foi comparar dois indutores de ovulação -benzoato de estradiol (grupo BE) ou prostaglandina F2α (grupo PG) -, em vacas leiteiras pós-parto submetidas à inseminação artificial em tempo fixo (IATF). Neste estudo, utilizaram-se vacas Girolando lactantes (n=118) com 60 a 120 dias em lactação. Todas as vacas foram tratadas com um implante intravaginal liberador de progesterona (CIDR) associado a 2 mg de benzoato de estradiol (BE) no dia 0. O CIDR foi retirado no dia 9, e todas as vacas receberam 500 µg i.m. de cloprostenol sódico (análogo à prostaglandina F2α Termos para indexação: inseminação artificial, bovinos, estro, sincronização, período de carência.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Prostaglandin F2α or estradiol benzoate to induce ovulation in timed artificially inseminated dairy cows

Pfeifer

Siqueira

Arashiro

et al. 2016

Pesq. agropec. bras.

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“…In the present study, all cows in the EB5 group, however, showed signs of estrus and ovulated within 5 days after CIDR withdrawal. The conflicting results between the present and previous [30] studies could be attributed to a larger body size and higher metabolic rate of EB in the dairy cows used in our study than the non-lactating beef cattle in the previous study. High feed intake to support a large amount of milk production in high-producing dairy cattle increases liver blood flow and metabolism of progesterone and estradiol [31].…”

Section: Discussioncontrasting

confidence: 55%

“…However, the duration of CIDR treatment needs to be extended when cows are inseminated during estrus induced by a CIDR treatment because the EB5 treatment with a 7-day CIDR insertion period may cause failure of ovulation after CIDR withdrawal due to insufficient time for follicular development and maturation. In a previous study, two out of eight non-lactating Hereford cows receiving a CIDR with 5 mg of EB and 500 μg of cloprostenol with a 7 day interval, similar to the EB5 treatment, failed to ovulate within 7 days after CIDR withdrawal, while all cows given 1 mg of EB ovulated within 6 days [30]. Treatment with 5 mg of EB suppresses FSH for an extended period compared with treatment with low doses (0.75, 1 and 2.5 mg) of EB [25,26], and follicular wave emergence can be expected to occur later and asynchronously [25,26,30].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, two out of eight non-lactating Hereford cows receiving a CIDR with 5 mg of EB and 500 μg of cloprostenol with a 7 day interval, similar to the EB5 treatment, failed to ovulate within 7 days after CIDR withdrawal, while all cows given 1 mg of EB ovulated within 6 days [30]. Treatment with 5 mg of EB suppresses FSH for an extended period compared with treatment with low doses (0.75, 1 and 2.5 mg) of EB [25,26], and follicular wave emergence can be expected to occur later and asynchronously [25,26,30]. Consequently, the size of the largest follicles becomes smaller, and some follicles may not acquire the ability to ovulate by the time of the LH surge.…”

Section: Discussionmentioning

confidence: 99%

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A Progestin-Based Treatment with a High Dose of Estradiol Benzoate Normalizes Cyclic Changes in Endometrial EGF Concentrations and Restores Fertility in Repeat Breeder Cows

Katagiri

Takahashi

2008

Journal of Reproduction and Development

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Abstract. The objective of the present study was to examine the efficacy of a progestin-based treatment with a high dose of estradiol benzoate (EB) to normalize the epidermal growth factor (EGF) profile in the uterine endometrium and restore fertility in repeat breeder cows. Repeat breeder cows without peaks in their endometrial EGF concentrations on Days 3 and 14 of the estrous cycle were used throughout the study. The effect of 1 (standard dose), 2.5 and 5 mg of EB in a progestin-based treatment protocol (EB1, EB2.5 and EB5 treatments, respectively; n=5 for each group) on endometrial EGF concentrations was first examined. The EB1 and EB2.5 treatments in the repeat breeder cows produced a suppressed response in endometrial EGF compared with EB1 treatment in the fertile controls (n=5) and failed to restore the normal EGF profile during the next estrous cycle. However, EB5 treatment produced an increase in EGF concentrations similar to the fertile controls and normalized the endometrial EGF profile. The effects of the EB1 and EB5 treatments (n=30 for each group) on the endometrial EGF profile and fertility were then examined in the repeat breeder cows. The proportion of cows, with an EGF profile normalized by the treatments was higher in the EB5 group (66.7%) than in the EB1 (30.0%) and untreated control (13.3%; n=30) groups (P<0.01). The pregnancy rates of the cows having a normal EGF profile after treatment in the EB1 and EB5 groups were similar (88.9 and 85.0%, respectively) and higher than those of the cows having an abnormal profile within the same groups (19.0 and 30.0%, respectively, P<0.01). In summary, the endometrial response to EB in terms of the EGF concentration was suppressed in repeat breeder cows. A high dose (5 mg) of EB in a progestin-based treatment was found to be effective for restoration of a normal EGF profile and fertility in repeat breeder cows having lesser endometrial EGF concentrations on Days 3 and 14. Key words: Controlled intravaginal drug release (CIDR), Dairy cattle, Epidermal growth factor (EGF), Endometrium, Repeat breeding (J. Reprod. Dev. 54: [473][474][475][476][477][478][479] 2008) rowing evidence indicates that ovarian steroid hormones (i.e., estrogen and progestin) primarily regulate uterine function by stimulating uterine production of growth factors and cytokines, although most of our knowledge in this field has been obtained in mice and rats. Among such local products, epidermal growth factor (EGF) and related ligands that share the EGF receptor have critical functions in the establishment of pregnancy [1,2]. Estrogen stimulates EGF production in the mouse uterus [3][4][5] and human oviducts [6]. Epidermal growth factor replaces estrogen in the stimulation of uterine and vaginal growth and endometrial cell differentiation (e.g., induction of lactoferrin, a major estrogeninducible secretory protein) in mice [7] and in a nidatory estrogen surge that initiates blastocyst attachment to the endometrium in rats [8]. In EGF receptor knockout mice, drastic negative effects o...

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Pharmacological Intervention of Estrous Cycles

Kasimanickam

2014

Bovine Reproduction

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Effects of oestradiol and some of its esters on gonadotrophin release and ovarian follicular dynamics in CIDR-treated beef cattle

Cited by 91 publications

References 37 publications

Prostaglandin F2α or estradiol benzoate to induce ovulation in timed artificially inseminated dairy cows

Prostaglandin F2α or estradiol benzoate to induce ovulation in timed artificially inseminated dairy cows

A Progestin-Based Treatment with a High Dose of Estradiol Benzoate Normalizes Cyclic Changes in Endometrial EGF Concentrations and Restores Fertility in Repeat Breeder Cows

Pharmacological Intervention of Estrous Cycles

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