Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients

Souza, Simone Raimondi de; Oliveira, Gláucia Maria Moraes de; Luiz, Ronir Raggio; Rosa, Glorimar

doi:10.20960/nh.40

Cited by 14 publications

(6 citation statements)

References 31 publications

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“…However, Kim et al [43] reported that the diet of diabetic mice foods high in fiber and polyunsaturated fatty acids resulted in decreased levels of triglycerides, total cholesterol and LDL-C, although it was not effective in improving glycemic control. However, Raimondi et al [44] showed that nutritional counseling has a beneficial effect on the lipid profile and anthropometric parameters and the daily consumption of 40 g of oat bran provided an additional benefit in reducing insulin resistance parameters.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of a Bioactive Food Compound in the Lipid Control of Individuals with HIV/AIDS

et al. 2016

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Cardiovascular events due to decompensated lipid metabolism are commonly found in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) patients using anti-retroviral therapy (HAART). Thus, the aim of this study was to identify the effect of a bioactive food compound (BFC) containing functional foods on individuals with HIV undergoing HAART. Particularly, this study aims to verify the clinical outcome in the change of the lipid profile due to the use of this compound. This study includes 115 individuals with HIV on HAART. All patients received dietary guidelines; however, sixty-one consumed BFC while fifty-one did not (NO BFC). Biochemical examinations and socio-demographic and clinical profiles were evaluated. As result, in patients using hypolipidemic and/or hypoglycemic drugs, there was 28.6% decrease in triglyceride levels (p < 0.001) in the NO BFC group, and 18.3% reduction in low density lipoprotein cholesterol (LDL-C) (p < 0.001) in the BFC group. In patients who did not use hypolipidemic and/or hypoglycemic drugs in the NO BFC group, there was 30.6% increase in triglycerides, 11.3% total cholesterol and 15.3% LDL-C levels (p < 0.001) while for the BFC group there was 4.5% reduction in total cholesterol (p < 0.001). In conclusion, this study evidenced that the dietary intervention containing BFC positively affected in lipid control, since these HIV/AIDS patients using HAART are more vulnerable to lipid disorders.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of a Bioactive Food Compound in the Lipid Control of Individuals with HIV/AIDS

et al. 2016

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“…One cereal pack (37.5 g) was prescribed to be mixed with 250 mL hot water twice daily Placebo (cereal without β-glucans) SC No Yes [ 71 ] Chen et al (2006) USA P 102 41 (40) Healthy subjects 47.9 (8.4) 12 weeks 60 g of oat bran concentrate as a muffin and 84 g of oatmeal squares 93 g of refined wheat as a muffin and 42 g of corn flakes L No Yes [ 72 ] Connolly et al (2016) England C 30 11 (36.7) Subjects with glucose intolerance or mild to moderate hypercholesterolemia 42 (N.R.) Two 6-week periods Whole grain oat granola cereal (45 g/d) Non-whole grain breakfast; 45 g/d SC Yes No [ 73 ] Davy et al (2002) USA P 36 36 (100) Overweight male subjects 58 (8.6) 12 weeks 60 g oatmeal and 76 g oat bran ready-to-eat cold cereal and the wheat group consumed 5.5 g β-glucans 60 g whole wheat cereals and 81 g frosted mini-wheats SC No Yes [ 74 ] De Souza et al (2016) Brazil P 132 44 (33.3) Hypercholesterolemic subjects …”

Section: Methodsmentioning

confidence: 99%

Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials

et al. 2022

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Purpose Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms. Methods We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers. Results Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) − 0.42 mmol/L, (− 0.61; − 0.22)], LDL cholesterol [− 0.29 mmol/L, (− 0.37; − 0.20)], glucose [− 0.25 nmol/L, (− 0.36; − 0.14)], body mass index [− 0.13 kg/m2, (− 0.26; − 0.01)], weight [− 0.94 kg, (− 1.84: − 0.05)], and waist circumference [− 1.06 cm, (− 1.85; − 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias. Conclusion Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.

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“…Some studies focused on the efficacy of oat intake. Two population-based randomized controlled trials reported a decrease in TC, LDL-C, and blood pressure and an increase in HDL-C in the oat group compared with those in the control group [ 44 , 45 ]. Two animal studies showed similar results and found a significant increase in fecal bile acids in the oat group, indicating that dietary oat improved hypercholesterolemia by increasing the excretions of fecal bile acids [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of adiponectin gene and gene–lipid interaction with hypertension risk in Chinese coal miners: A matched case-control study

Bai

et al. 2022

PLoS ONE

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Objective Low serum adiponectin level can predict hypertension development, and adiponectin gene (ADIPOQ) polymorphisms have been reported to be linked with hypertension risk. Whereas, the interaction between ADIPOQ polymorphisms and environmental factors on the susceptibility of hypertension remained unclear. The purpose of this study was to explore the relationship of ADIPOQ polymorphisms with hypertension risk and their interaction with lipid levels in coal miners. Methods A matched case-control study with 296 case-control pairs was performed in a large coal mining group located in North China. The participants were questioned by trained interviewers, and their ADIPOQ genotype and lipid levels were determined. Logistic regression, stratified analysis, and crossover analysis were applied to evaluate the effects of rs2241766, rs1501299, and rs266729 genotypes and gene–lipid interaction on hypertension risk. Results In this matched case-control study, the genotypes of rs2241766 TG+GG, rs1501299 GT+TT, and rs266729 CG+GG were marginally related to hypertension risk. Individuals with high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) level were susceptible to hypertension (TC: odds ratio [OR] = 1.807, 95% confidence intervals [95%CI] = 1.266–2.581; LDL-C: OR = 1.981, 95%CI = 1.400–2.803; HDL-C: OR = 1.559, 95%CI = 1.093–2.223). Antagonistic interactions were detected between rs2241766 and TC, rs1501299 and TC, rs2241766 and LDL-C, and rs1501299 and HDL-C (rs2241766 and TC: OR = 0.393, 95%CI = 0.191–0.806; rs1501299 and TC: OR = 0.445, 95%CI = 0.216–0.918; rs2241766 and LDL-C: OR = 0.440, 95%CI = 0.221–0.877; rs1501299 and HDL-C: OR = 0.479, 95%CI = 0.237–0.967). Stratified analysis showed that hypertension risk was high for the subjects with rs2241766 TG+GG or rs1501299 GG under the low lipid level but low for those under the high lipid level. In the case group, the TC and LDL-C levels for rs2241766 TG+GG were lower than those for rs2241766 GG, and the TC and HDL-C levels for rs1501299 GT+TT were higher than those for rs1501299 GG. Conclusions Although the effects of ADIPOQ polymorphisms alone were not remarkable, an antagonistic interaction was observed between ADIPOQ polymorphisms and lipid levels.

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Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients

Cited by 14 publications

References 31 publications

The Effectiveness of a Bioactive Food Compound in the Lipid Control of Individuals with HIV/AIDS

The Effectiveness of a Bioactive Food Compound in the Lipid Control of Individuals with HIV/AIDS

Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials

Polymorphisms of adiponectin gene and gene–lipid interaction with hypertension risk in Chinese coal miners: A matched case-control study

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