Effects of nutrition and physical exercise intervention in palliative cancer patients: A randomized controlled trial

Uster, A.; Ruehlin, Maya; Mey, S.; Gisi, David; Knols, Ruud H.; Imoberdorf, Reinhard; Pless, Miklos; Ballmer, Peter E.

doi:10.1016/j.clnu.2017.05.027

Cited by 112 publications

(230 citation statements)

References 27 publications

Supporting

Mentioning

217

Contrasting

Unclassified

Order By: Relevance

“…However, there is no standard multimodal intervention combining with these investigational agents. Previous multimodal intervention trials in patients with advanced cancer had poor recruitment, poor compliance, and minimal impact on physical function or quality of life . The burden of multiple assessments, extra effort, and time spent in the intervention may have decreased compliance.…”

Section: Introductionmentioning

confidence: 99%

“…Previous multimodal intervention trials in patients with advanced cancer had poor recruitment, poor compliance, and minimal impact on physical function 13 or quality of life. 14 The burden of multiple assessments, extra effort, and time spent in the intervention may have decreased compliance. Inclusion of patients in later phases of the cancer course may further limit feasibility and efficacy of the interventions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer

Naito

Mitsunaga

Miura

et al. 2018

J cachexia sarcopenia muscle

110

145

View full text Add to dashboard Cite

Background Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. Methods This was a multicentre prospective single‐arm study. We recruited 30 of 46 screened patients aged ≥70 years scheduled to receive first‐line chemotherapy for newly diagnosed, advanced pancreatic, or non‐small‐cell lung cancer. Physical activity was measured using pedometers/accelerometer (Lifecorder ® , Suzuken Co., Ltd., Japan). An 8 week educational intervention comprised three exercise and three nutritional sessions. The exercise interventions combined home‐based low‐intensity resistance training and counselling to promote physical activity. Nutritional interventions included standard nutritional counselling and instruction on how to manage symptoms that interfere with patient's appetite and oral intake. Supplements rich in branched‐chain amino acids (Inner Power ® , Otsuka Pharmaceutical Co., Ltd., Japan) were provided. The primary endpoint of the study was feasibility, which was defined as the proportion of patients attending ≥4 of six sessions. Secondary endpoints included compliance and safety. Results The median patient age was 75 years (range, 70–84). Twelve patients (40%) were cachectic at baseline. Twenty‐nine patients attended ≥4 of the six planned sessions (96.7%, 95% confidence interval, 83.3 to 99.4). One patient dropped out due to deteriorating health status. The median proportion of days of compliance with supplement consumption and exercise performance were 99% and 91%, respectively. Adverse events possibly related to the NEXTAC programme were observed in five patients and included muscle pain (Grade 1 in two patients), arthralgia (Grade 1 in one patient), dyspnoea on exertion (Grade 1 in one patient), and plantar aponeurositis (Grade 1 in one patient). Conclusions The early induction of multimodal interventions showed excellent compliance and safety in elderly patients with newly diagnosed pancreatic and non‐small‐cell lung cancer receiving concurrent chemotherapy. We are now conducting a randomized phase II study to measure the impact of these interventions on functional prognosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer

Naito

Mitsunaga

Miura

et al. 2018

J cachexia sarcopenia muscle

110

145

View full text Add to dashboard Cite

show abstract

“…Chemotherapeutic agents are known to trigger the secretion of neurotransmitters such as serotonin and substance P mitigating vagal signaling [40]. Currently a limited number of studies have investigated the efficacy of nutrition intervention for cancer treatment associated nausea and vomiting nutrition intervention in palliative cancer patients improved patient-rated symptom of nausea and vomiting while there was difference in other measures [41]. Another intervention study using a home delivery meal service found significantly positive association between energy and protein intake and QoL indicating improved food intake [42].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Cereal-based Oral Nutrition Supplement on Nutritional Status, Inflammatory Cytokine Secretion and Quality of Life in Cancer Patients Under Cancer Therapy

Kim

Hong

Song³

et al. 2020

J Cancer Prev

View full text Add to dashboard Cite

A rapid increase in cancer incidence accompanied by aging population requires evidence-based supportive cancer care practices. Cancer therapies often accompany adverse events which induce malnutrition and declined quality of life. We conducted an 8-week non-randomized clinical trial to evaluate efficacy of cereal-based oral nutritional supplement (ONS) intervention on nutritional status, quality of life and inflammatory responses in cancer patients undergoing cancer therapy with 5% < weight loss. The study included 34 pateints (24 in control group, 10 in intervention group) with 15 drop-outs. ONS used in this intervention contained 0.5% arabinoxylan-rich fermented rice bran powder and 5.5% black rice powder as active ingredients in a regular cereal-based formula. Results showed that ONS intervention for 8 weeks did not show significant improvement in blood biomarkers of nutritional status or patient-generated subjective global assessment scores. However, 8-week of intervention showed reduced interleukin (IL)-6 and IL-1b secretion in lipopolysaccharide-stimulated peripheral blood mononuclear cells while IL-12p70 level was increased. For health-related quality of life (HRQoL) indices, emotional functioning and fatigue symptoms were improved after 4 weeks only in the intervention group although no difference was found at week 8. These results suggest that ONS intervention may improve chronic inflammatory status and HRQoL indices (at week 4) in cancer patients receiving treatments.

show abstract

“…Eight studies were eligible enrolling a total of 685 participants. Studies included two randomised control trials (RCTs) [ 22 , 23 ], three prospective studies [ 24 – 26 ], two secondary analyses of quasi-experimental data [ 1 , 27 ] and one exploratory study [ 28 ]. All interventions were outpatient-based rehabilitation programmes: seven in hospitals and one hospice-based.…”

Section: Resultsmentioning

confidence: 99%

Combined exercise and nutritional rehabilitation in outpatients with incurable cancer: a systematic review

Hall

Cook²,

Maddocks

et al. 2019

Support Care Cancer

View full text Add to dashboard Cite

Purpose The optimal components for rehabilitation in patients with incurable cancer are unclear. However, principles of exercise and nutrition-based interventions used in cancer cachexia may be applied usefully to this population of cancer patients. This systematic review examines current evidence for rehabilitation combining exercise and nutritional support in patients with incurable cancer. Methods MEDLINE, EMBASE and Cochrane databases were searched. Eligible studies included patients with incurable cancer and rehabilitation programmes combining exercise and nutritional interventions. Studies of cancer survivors, curative treatments, reviews, case note reviews, protocols and abstracts were excluded. Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria were applied to patient-important outcomes. Results Of the 2424 search results, 67 abstracts were reviewed and 24 full texts examined. Eight studies ( n = 685) were included comprising two randomised control trials, three prospective, one exploratory and two secondary analyses. All examined multi-modal outpatient programmes. GRADE analysis revealed moderate evidence (B) for improvements in depression and physical endurance, low-quality evidence (C) for quality of life and fatigue and very low–quality evidence (D) for overall function and nutritional status. Conclusion There are limited data for multi-modal rehabilitation programmes combining exercise and nutritional interventions in patients with incurable cancer. However, studies to date report improvements in multiple domains, most notably physical endurance and depression scores. This supports the concept that multi-modal rehabilitation incorporating principles of cachexia management may be appropriate for the wider group of patients with incurable cancer. Further, high-quality studies are needed to define the optimal approach and outcome measures.

show abstract

Effects of nutrition and physical exercise intervention in palliative cancer patients: A randomized controlled trial

Cited by 112 publications

References 27 publications

Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer

Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer

Efficacy of Cereal-based Oral Nutrition Supplement on Nutritional Status, Inflammatory Cytokine Secretion and Quality of Life in Cancer Patients Under Cancer Therapy

Combined exercise and nutritional rehabilitation in outpatients with incurable cancer: a systematic review

Contact Info

Product

Resources

About