Effects of novelty and conditioned fear on small intestinal and colonic motility and behaviour in the rat

Stam, Rianne; Croiset, Gerda; Akkermans, L.M.A.; Wiegant, V.M.

doi:10.1016/0031-9384(95)00137-8

Cited by 20 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Continuous exposition to stressors induces delayed gastric emptying in both experimental animals and healthy human beings [11,[18][19][20], although their underlying mechanisms remain poorly characterized [11]. Delayed gastric emptying has been found in many patients with FD [21][22][23], but other studies have failed to identify any association between delayed gastric emptying and any dyspeptic symptoms [24,25].…”

Section: Introductionmentioning

confidence: 99%

Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

Roca-Chiapas

Solís

Fajardo-Araujo

et al. 2010

Journal of Psychosomatic Research

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

Roca-Chiapas

Solís

Fajardo-Araujo

et al. 2010

Journal of Psychosomatic Research

View full text Add to dashboard Cite

“…Considering the fact that IBS predominantly affects women and that symptoms consistent with IBS are most prevalent in patients with functional GI disorders, it is interesting to note that female rats are more sensitive to the effects of stress on intestinal transit than male rats, and that the colon seems to be more responsive to the effects of stress on motor activity than the upper GI tract [44][45][46].…”

Section: Mechanisms Of Stress Effects On Gi Motility In Experimental mentioning

confidence: 99%

Role of Stress in Functional Gastrointestinal Disorders

Mönnikes

Tebbe²,

Hildebrandt³

et al. 2001

Dig Dis

231

View full text Add to dashboard Cite

Psychological stress is widely believed to play a major role in functional gastrointestinal (GI) disorders, especially irritable bowel syndrome (IBS), by precipitating exacerbation of symptoms. The available data clearly demonstrate that inhibition of gastric emptying and stimulation of colonic transit is the most consistent pattern in the motility response of the GI tract to acute or short-term stress. Thus, one might propose that these alterations might play a pathophysiological role in dyspeptic symptoms and alterations in stool frequency and consistency in patients with stress-related functional GI disorders. Taken together, the above-mentioned studies suggest that the colonic motor response to stress is exaggerated in IBS. There is evidence that an increased emotional response is associated with this difference in colonic, and perhaps also gastric motor responses to certain stressors. However, almost no valid data are available so far from human studies addressing the question if differences in motility responses to stress between patients with functional GI disorders and healthy subjects are due to an altered stress response associated with an imbalance of the autonomic nervous system or increased stress susceptibility. We can summarize that in experimental animals the most consistent pattern of GI motor alterations induced by various psychological and physical stressors is that of delaying gastric emptying and accelerating colonic transit. Endogenous corticotropin-releasing factor (CRF) in the brain plays a significant role in the central nervous system mediation of stress-induced inhibition of upper GI and stimulation of lower GI motor function through activation of brain CRF receptors. The inhibition of gastric emptying by CRF may be mediated by interaction with the CRF-2 receptor, while CRF-1 receptors are involved in the colonic and anxiogenic responses to stress. Endogenous serotonin, peripherally released in response to stress, seems to be involved in stress- and central CRF-induced stimulation of colonic motility by acting on 5HT-3 receptors. Taken together, the limited data available from investigations in healthy subjects and patients with functional GI disorders provide some evidence that stress affects visceral sensitivity in humans. Acute psychological stress seems to facilitate increased sensitivity to experimental visceral stimuli, if the stressor induces a significant emotional change. In summary, studies in experimental animals suggest that stress-induced visceral hypersensitivity is centrally mediated by endogenous CRF and involvement of structures of the emotional motor system, e.g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity.

show abstract

“…During fasting the motor activity of the small intestine shows a highly organized pattern and is characterized by a sequence of specific and recurrent myoelectric events defined as migrating motor complex (1,(4)(5)(6). In contrast, the myoelectric activity that follows food ingestion has no regular pattern (3).…”

Section: Introductionmentioning

confidence: 99%

Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats

Tabosa

Yamamura

Forno

et al. 2002

Braz J Med Biol Res

View full text Add to dashboard Cite

Despite its ancient use as a therapeutic tool to treat several ailments, acupuncture still faces the challenge of scrutiny by Western science both in terms of its efficacy and in terms of the characterization of its effects and mechanisms of actions underlying these effects. We investigated under well-controlled and carefully characterized conditions the influence of electrical stimulation of acupuncture points ST-36 (Zusanli) and SP-6 (Sanyinjiao) on the myoelectric activity of the small intestine of 38 adult male Wistar rats. Electrical recordings obtained by means of four electrodes chronically implanted in the small intestine were used to assess the effects of acupuncture (electroacupuncture stimulation set at 2 Hz, intermittent stimulation, 1 V, for 30 min). Immobilization of the animals was associated with a consistent decrease (-8 ± 7%) in the myoelectric activity of the small intestine as measured by means of the root mean square. Conversely, acupuncture was able to significantly increase (overshoot) this activity compared to baseline (+44 ± 7%). In contrast, immobilized animals subjected to sham acupuncture had only modest (nonsignificant) increases in myoelectric activity (+9 ± 6%). Using carefully controlled conditions we confirmed previous noncontrolled studies on the ability of acupuncture to alter intestinal motility. The characterization of the topographic and temporal profiles of the effects observed here represents a basis for future dissection of the physiological and pharmacological systems underlying these effects. Correspondence

show abstract

Effects of novelty and conditioned fear on small intestinal and colonic motility and behaviour in the rat

Cited by 20 publications

References 32 publications

Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

Role of Stress in Functional Gastrointestinal Disorders

Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats

Contact Info

Product

Resources

About