Effects of normalization approach and global covariates on voxel-based morphometry: Comparing DARTEL and standard SPM approaches using age-related cortical change

Peelle, JE; Cusack, Rhodri; Henson, Rna

doi:10.1016/s1053-8119(09)71165-6

Cited by 2 publications

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“…An analysis of agerelated decreases in grey matter volume showed more focal results using DARTEL than using the standard approach, where registration errors were observed on the edges of the images. 41 It is not surprising that we found a reduced volume of a portion the caudate, given that studies using diverse functional imaging techniques (e.g., positron emission tomography) have shown a malfunction in the striatum of adults with ADHD. [42][43][44] Considering our findings and the fact that few studies involving adult ADHD patients have been published, there is a need for additional research into the volume of the caudate nucleus in adults with ADHD.…”

Section: Discussionmentioning

confidence: 68%

“…40 The extrapolation of the results from this study must be handled with caution because Segall and colleagues 40 included patients with schizophrenia, and the DARTEL algorithm was not used. In a recent study by Peelle and colleagues, 41 MRI scans of 330 participants (18-78 yr) were analyzed using SPM5 software. Images of the grey matter were normalized to either an MNI template (the "standard" approach) or to an average template using DARTEL.…”

Section: Discussionmentioning

confidence: 99%

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Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Montes

Ricardo-Garcell

Torre

et al. 2010

jpn

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Background: Magnetic resonance imaging (MRI) studies have shown decreased caudate volumes in individuals with attention deficit hyperactivity disorder (ADHD). However, most of these studies have been carried out in male children. Very little research has been done in adults, and the results obtained in children are difficult to extrapolate to adults. We sought to compare the volume of the caudate of adults with ADHD with that of healthy controls; we also compared these volumes between men and women. Methods: We performed an MRI scan on 20 adults with ADHD (10 men and 10 women) aged 25-35 years and 20 healthy controls matched by age and sex. We used voxel-based morphometry with the DARTEL algorithm for image analyses. We used the specifically designed Friederichsen, Almeida, Serrano, Cortes Test (FASCT) to measure the severity of ADHD; both the self-reported (FASCT-SR) and the observer (FASCT-O) versions were used. Results: The statistical parametric map showed a smaller region with low grey matter volume and a smaller concentration of grey matter in this region of the right caudate in ADHD patients than in health controls, both in the entire sample and within each sex. There was a significant correlation between the volume of this region of the caudate with the number of DSM IV-TR criteria, as well as with the total scores and most of the factors of the FASCT-SR and FASCT-O scales. A separate correlation analysis by sex gave similar results. Limitations: The study design was cross-sectional. Conclusion: The region of the right caudate with low grey matter volume was smaller in adults with ADHD in both sexes and was correlated with ADHD severity.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Montes

Ricardo-Garcell

Torre

et al. 2010

jpn

View full text Add to dashboard Cite

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Defining the habenula in human neuroimaging studies

2013

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Recently there has been renewed interest in the habenula; a pair of small, highly evolutionarily conserved epithalamic nuclei adjacent to the medial dorsal (MD) nucleus of the thalamus. The habenula has been implicated in a range of behaviours including sleep, stress and pain, and studies in non-human primates have suggested a potentially important role in reinforcement processing, putatively via its effects on monoaminergic neurotransmission. Over the last decade, an increasing number of neuroimaging studies have reported functional responses in the human habenula using functional magnetic resonance imaging (fMRI). However, standard fMRI analysis approaches face several challenges in isolating signal from this structure because of its relatively small size, around 30 mm3 in volume. In this paper we offer a set of guidelines for locating and manually tracing the habenula in humans using high-resolution T1-weighted structural images. We also offer recommendations for appropriate pre-processing and analysis of high-resolution functional magnetic resonance imaging (fMRI) data such that signal from the habenula can be accurately resolved from that in surrounding structures.

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Effects of normalization approach and global covariates on voxel-based morphometry: Comparing DARTEL and standard SPM approaches using age-related cortical change

Cited by 2 publications

References 0 publications

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Defining the habenula in human neuroimaging studies

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